ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts
about
Multiple ATR-Chk1 pathway proteins preferentially associate with checkpoint-inducing DNA substratesThe FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cellsMutations affecting a putative MutLalpha endonuclease motif impact multiple mismatch repair functionsDNA mismatch repair: molecular mechanism, cancer, and ageingGenotoxic anti-cancer agents and their relationship to DNA damage, mitosis, and checkpoint adaptation in proliferating cancer cellsMolecular basis of selectivity of nucleoside triphosphate incorporation opposite O6-benzylguanine by sulfolobus solfataricus DNA polymerase Dpo4: steady-state and pre-steady-state kinetics and x-ray crystallography of correct and incorrect pairingPostreplicative mismatch repair.ATR mutation in endometrioid endometrial cancer is associated with poor clinical outcomes.Mechanisms and functions of DNA mismatch repairStructural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activitiesDNA mismatch repair in eukaryotes and bacteriaDNA replication fidelity and cancerATR: an essential regulator of genome integrityCombining modularity, conservation, and interactions of proteins significantly increases precision and coverage of protein function predictionThe identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O⁶-methylguanineHuman MLH1 protein participates in genomic damage checkpoint signaling in response to DNA interstrand crosslinks, while MSH2 functions in DNA repairThe basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling.Diverse effects of individual mismatch repair components on transcription-induced CAG repeat instability in human cells.DNA lesions induced by replication stress trigger mitotic aberration and tetraploidy developmentTipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress.Embryonic lethality after combined inactivation of Fancd2 and Mlh1 in mice.Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling.Nuclear reorganization of DNA mismatch repair proteins in response to DNA damage.Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway.The mismatch repair system modulates curcumin sensitivity through induction of DNA strand breaks and activation of G2-M checkpoint.Epstein-Barr virus DNase (BGLF5) induces genomic instability in human epithelial cells.Histone/protein deacetylase SIRT1 is an anticancer therapeutic target.Interaction between human mismatch repair recognition proteins and checkpoint sensor Rad9-Rad1-Hus1Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment.The DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) Are stimulated by bulky adduct-containing DNA.Targeting and processing of site-specific DNA interstrand crosslinks.Onset of quiescence following p53 mediated down-regulation of H2AX in normal cells.Human pluripotent stem cells have a novel mismatch repair-dependent damage response.Alkyltransferase-like protein (eATL) prevents mismatch repair-mediated toxicity induced by O6-alkylguanine adducts in Escherichia coli.O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation.S-phase sensing of DNA-protein crosslinks triggers TopBP1-independent ATR activation and p53-mediated cell death by formaldehyde.O6-methylguanine-DNA methyltransferase in the defense against N-nitroso compounds and colorectal cancer.New insights into the link between DNA damage and apoptosis.Phosphorylated hMSH6: DNA mismatch versus DNA damage recognition.The mechanism of mismatch repair and the functional analysis of mismatch repair defects in Lynch syndrome.
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P2860
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts
description
2006 nî lūn-bûn
@nan
2006 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
ATR kinase activation mediated ...... toxic O6-methylguanine adducts
@ast
ATR kinase activation mediated ...... toxic O6-methylguanine adducts
@en
ATR kinase activation mediated ...... toxic O6-methylguanine adducts
@en-gb
ATR kinase activation mediated ...... toxic O6-methylguanine adducts
@nl
type
label
ATR kinase activation mediated ...... toxic O6-methylguanine adducts
@ast
ATR kinase activation mediated ...... toxic O6-methylguanine adducts
@en
ATR kinase activation mediated ...... toxic O6-methylguanine adducts
@en-gb
ATR kinase activation mediated ...... toxic O6-methylguanine adducts
@nl
prefLabel
ATR kinase activation mediated ...... toxic O6-methylguanine adducts
@ast
ATR kinase activation mediated ...... toxic O6-methylguanine adducts
@en
ATR kinase activation mediated ...... toxic O6-methylguanine adducts
@en-gb
ATR kinase activation mediated ...... toxic O6-methylguanine adducts
@nl
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P2860
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P1433
P1476
ATR kinase activation mediated ...... toxic O6-methylguanine adducts
@en
P2093
Ken-ichi Yoshioka
Peggy Hsieh
Yoshiko Yoshioka
P2860
P304
P3181
P356
10.1016/J.MOLCEL.2006.04.023
P407
P577
2006-05-19T00:00:00Z