Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres. - Test2 - elhamkhani - TriplyDB

Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres.

Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres.

http://www.wikidata.org/entity/Q24536297

about

Human Ku70/80 interacts directly with hTR, the RNA component of human telomerase Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice.Visualizing telomere dynamics in living mammalian cells using PNA probes Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer A conserved and species-specific functional interaction between the Werner syndrome-like exonuclease atWEX and the Ku heterodimer in Arabidopsis The role of RecQ helicases in non-homologous end-joining Mating type influences chromosome loss and replicative senescence in telomerase-deficient budding yeast by Dnl4-dependent telomere fusion.Human Ku70/80 associates physically with telomerase through interaction with hTERT Ku86 represses lethal telomere deletion events in human somatic cells The role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse Defective DNA repair and increased genomic instability in Artemis-deficient murine cells Telomeres and human disease: ageing, cancer and beyond Comparative biology of telomeres: where plants stand.TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends.An increase in telomere sister chromatid exchange in murine embryonic stem cells possessing critically shortened telomeres.Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging.The Candida albicans Ku70 modulates telomere length and structure by regulating both telomerase and recombination.Regulation of telomere length and suppression of genomic instability in human somatic cells by Ku86 Healthy lifestyle and leukocyte telomere length in U.S. women Molecular analysis of telomere fusions in Arabidopsis: multiple pathways for chromosome end-joining Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells.Telomeres in cancer and ageing.Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation.Ku is required for telomeric C-rich strand maintenance but not for end-to-end chromosome fusions in Arabidopsis Controlled somatic and germline copy number variation in the mouse model PARP1 Is a TRF2-associated poly(ADP-ribose)polymerase and protects eroded telomeres.The Ku protein complex is involved in length regulation of Drosophila telomeres.Telomeres, chromosome instability and cancer Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres.High-throughput telomere length quantification by FISH and its application to human population studies.Increased p53 activity does not accelerate telomere-driven ageing.Depletion of Ku70/80 reduces the levels of extrachromosomal telomeric circles and inhibits proliferation of ALT cells.Fungal Ku prevents permanent cell cycle arrest by suppressing DNA damage signaling at telomeres.Role of mammalian Rad54 in telomere length maintenance.Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling Genome integrity, stem cells and hyaluronan.Targeted deletion reveals an essential function for the telomere length regulator Trf1.Functional interaction between poly(ADP-Ribose) polymerase 2 (PARP-2) and TRF2: PARP activity negatively regulates TRF2.

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P2860

Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres.

http://www.wikidata.org/entity/Q24536297

description

2002 nî lūn-bûn

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2002 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2002 թվականի մայիսին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

Mammalian Ku86 mediates chromo ...... by critically short telomeres

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Mammalian Ku86 mediates chromo ...... by critically short telomeres.

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Mammalian Ku86 mediates chromo ...... by critically short telomeres.

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type

label

Mammalian Ku86 mediates chromo ...... by critically short telomeres

@nl

Mammalian Ku86 mediates chromo ...... by critically short telomeres.

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Mammalian Ku86 mediates chromo ...... by critically short telomeres.

@en

prefLabel

Mammalian Ku86 mediates chromo ...... by critically short telomeres

@nl

Mammalian Ku86 mediates chromo ...... by critically short telomeres.

@ast

Mammalian Ku86 mediates chromo ...... by critically short telomeres.

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P1433

The EMBO Journal

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Mammalian Ku86 mediates chromo ...... by critically short telomeres.

@en

P2093

Juan C Cigudosa

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Silvia Espejel

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Simon D Bouffler

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Sonia Franco

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P2860

Mammalian telomeres end in a large duplex loop

Ku binds telomeric DNA in vitro

Ku is associated with the telomere in mammals

TIN2, a new regulator of telomere length in human cells

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

Interaction of human Ku70 with TRF2

Control of telomere length by the human telomeric protein TRF1

Control of human telomere length by TRF1 and TRF2

TRF2 Protects Human Telomeres from End-to-End Fusions

Deletion of Ku86 causes early onset of senescence in mice

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2207-2219

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scholarly article

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2551217

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10.1093/EMBOJ/21.9.2207

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9

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21

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Sandra Rodriguez-Perales

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2002-05-01T00:00:00Z

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11388215

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11980718

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apoptotic process

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125978

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