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Interaction of human Ku70 with TRF2In vitro and in vivo interactions of DNA ligase IV with a subunit of the condensin complexTargeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2The human Rap1 protein complex and modulation of telomere lengthMammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres.Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice.Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminusShelterin complex and associated factors at human telomeresProkaryotic homologs of the eukaryotic DNA-end-binding protein Ku, novel domains in the Ku protein and prediction of a prokaryotic double-strand break repair systemHuman Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubulesDeletion of Ku70, Ku80, or both causes early aging without substantially increased cancerKu and the Stability of the GenomeCdc13 cooperates with the yeast Ku proteins and Stn1 to regulate telomerase recruitmentHuman Ku70/80 associates physically with telomerase through interaction with hTERTTRF2 interaction with Ku heterotetramerization interface gives insight into c-NHEJ prevention at human telomeresHuman LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunctionFunctional interaction between Ku and the werner syndrome protein in DNA end processingDNA-protein kinase catalytic subunit-interacting protein KIP binds telomerase by interacting with human telomerase reverse transcriptaseThe role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint controlDNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouseDefective DNA repair and increased genomic instability in Artemis-deficient murine cellsCell cycle-dependent regulation of yeast telomerase by Ku.Protection of telomeres by the Ku protein in fission yeast.Nuclear clusterin/XIP8, an x-ray-induced Ku70-binding protein that signals cell death.Alterations of DNA and chromatin structures at telomeres and genetic instability in mouse cells defective in DNA polymerase alpha.Trf1 is not required for proliferation or functional telomere maintenance in chicken DT40 cells.Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction.Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang.An alternate form of Ku80 is required for DNA end-binding activity in mammalian mitochondria.Preclinical evaluation of (111)In-DTPA-INCA-X anti-Ku70/Ku80 monoclonal antibody in prostate cancerMutant huntingtin impairs Ku70-mediated DNA repair.Involvement of cellular double-stranded DNA break binding proteins in processing of the recombinant adeno-associated virus genome.TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends.Revealing novel telomere proteins using in vivo cross-linking, tandem affinity purification, and label-free quantitative LC-FTICR-MSKu86 is essential in human somatic cells.Telomere dysfunction triggers developmentally regulated germ cell apoptosis.DNA-PKcs is critical for telomere cappingThe absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang.A functional variant of tandem repeats in human telomerase gene was associated with survival of patients with early stages of non-small cell lung cancerT-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang.
P2860
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P2860
description
1999 nî lūn-bûn
@nan
1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
name
Ku is associated with the telomere in mammals
@ast
Ku is associated with the telomere in mammals
@en
Ku is associated with the telomere in mammals
@en-gb
Ku is associated with the telomere in mammals
@nl
type
label
Ku is associated with the telomere in mammals
@ast
Ku is associated with the telomere in mammals
@en
Ku is associated with the telomere in mammals
@en-gb
Ku is associated with the telomere in mammals
@nl
prefLabel
Ku is associated with the telomere in mammals
@ast
Ku is associated with the telomere in mammals
@en
Ku is associated with the telomere in mammals
@en-gb
Ku is associated with the telomere in mammals
@nl
P2093
P2860
P356
P1476
Ku is associated with the telomere in mammals
@en
P2093
P2860
P304
P356
10.1073/PNAS.96.22.12454
P407
P577
1999-10-26T00:00:00Z