X-linked mental retardation gene CUL4B targets ubiquitylation of H3K4 methyltransferase component WDR5 and regulates neuronal gene expression
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CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signalingA Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly.Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4BCullin4A and cullin4B are interchangeable for HIV Vpr and Vpx action through the CRL4 ubiquitin ligase complexVariants in CUL4B are associated with cerebral malformationsEssential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesisCRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growthNEDDylation is essential for Kaposi's sarcoma-associated herpesvirus latency and lytic reactivation and represents a novel anti-KSHV targetCRL4A(CRBN) E3 ubiquitin ligase restricts BK channel activity and prevents epileptogenesis.Cul4B regulates neural progenitor cell growth.Genome instability in blood cells of a BRCA1+ breast cancer family.The role of cullin4B in human cancers.Accelerated hepatocellular carcinoma development in CUL4B transgenic miceRegulation of histone H3K4 methylation in brain development and disease.Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development.Intellectual disability and autism spectrum disorders: causal genes and molecular mechanisms.CRL4(VprBP) E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases.Intellectual disability-associated dBRWD3 regulates gene expression through inhibition of HIRA/YEM-mediated chromatin deposition of histone H3.3.WD repeat-containing protein 5 (WDR5) localizes to the midbody and regulates abscission.A Non-Canonical Function of Gβ as a Subunit of E3 Ligase in Targeting GRK2 UbiquitylationDNA damage-induced activation of CUL4B targets HUWE1 for proteasomal degradation.Pathogenic Role of the CRL4 Ubiquitin Ligase in Human DiseaseAkt Phosphorylates Wnt Coactivator and Chromatin Effector Pygo2 at Serine 48 to Antagonize Its Ubiquitin/Proteasome-mediated Degradation.S6 Kinase- and β-TrCP2-Dependent Degradation of p19Arf Is Required for Cell ProliferationCUL4B ubiquitin ligase in mouse development: a model for human X-linked mental retardation syndrome?CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade.Ramshackle (Brwd3) promotes light-induced ubiquitylation of Drosophila Cryptochrome by DDB1-CUL4-ROC1 E3 ligase complexHepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV Replication.Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency.The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligaseCullin-RING Ligases as attractive anti-cancer targets.E3 ubiquitin ligase Cullin4B mediated polyubiquitination of p53 for its degradation.CRL4B promotes tumorigenesis by coordinating with SUV39H1/HP1/DNMT3A in DNA methylation-based epigenetic silencing.Guard the guardian: A CRL4 ligase stands watch over histone production.Dysregulation of the miR-194-CUL4B negative feedback loop drives tumorigenesis in non-small-cell lung carcinoma.A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions.Polycomb PRC2 complex mediates epigenetic silencing of a critical osteogenic master regulator in the hippocampusChromatin regulation by CRL4 E3 ubiquitin ligases: CUL4B targets WDR5 ubiquitylation in the nucleus.AtRAE1 is involved in degradation of ABA receptor RCAR1 and negatively regulates ABA signalling in Arabidopsis.CRL4 antagonizes SCFFbxo7-mediated turnover of cereblon and BK channel to regulate learning and memory.
P2860
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P2860
X-linked mental retardation gene CUL4B targets ubiquitylation of H3K4 methyltransferase component WDR5 and regulates neuronal gene expression
description
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2011
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im August 2011 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2011/08/05)
@sk
vědecký článek publikovaný v roce 2011
@cs
wetenschappelijk artikel (gepubliceerd op 2011/08/05)
@nl
наукова стаття, опублікована в серпні 2011
@uk
مقالة علمية (نشرت في 5-8-2011)
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name
X-linked mental retardation ge ...... lates neuronal gene expression
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X-linked mental retardation ge ...... lates neuronal gene expression
@en
X-linked mental retardation ge ...... lates neuronal gene expression
@nl
type
label
X-linked mental retardation ge ...... lates neuronal gene expression
@ast
X-linked mental retardation ge ...... lates neuronal gene expression
@en
X-linked mental retardation ge ...... lates neuronal gene expression
@nl
prefLabel
X-linked mental retardation ge ...... lates neuronal gene expression
@ast
X-linked mental retardation ge ...... lates neuronal gene expression
@en
X-linked mental retardation ge ...... lates neuronal gene expression
@nl
P2860
P1433
P1476
X-linked mental retardation ge ...... lates neuronal gene expression
@en
P2093
Tadashi Nakagawa
P2860
P304
P356
10.1016/J.MOLCEL.2011.05.033
P577
2011-08-05T00:00:00Z