Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis - Test2 - elhamkhani - TriplyDB

Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis

Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis

http://www.wikidata.org/entity/Q28262931

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The role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility.Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B Ubiquitylation, neddylation and the DNA damage response A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase Ubiquitin E3 ligase CRL4(CDT2/DCAF2) as a potential chemotherapeutic target for ovarian surface epithelial cancer CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration.The role of cullin4B in human cancers.Accelerated hepatocellular carcinoma development in CUL4B transgenic mice Improved ex vivo expansion of adult hematopoietic stem cells by overcoming CUL4-mediated degradation of HOXB4.A Non-Canonical Function of Gβ as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation Akt Phosphorylates Wnt Coactivator and Chromatin Effector Pygo2 at Serine 48 to Antagonize Its Ubiquitin/Proteasome-mediated Degradation.CUL4B ubiquitin ligase in mouse development: a model for human X-linked mental retardation syndrome?SCF(β-TRCP) promotes cell growth by targeting PR-Set7/Set8 for degradation CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade.Cell Autonomous and Nonautonomous Function of CUL4B in Mouse Spermatogenesis.The CUL4A ubiquitin ligase is a potential therapeutic target in skin cancer and other malignancies.HUWE1 plays important role in mouse preimplantation embryo development and the dysregulation is associated with poor embryo development in humans Cullin-RING Ligases as attractive anti-cancer targets.Dysregulation of CUL4A and CUL4B Ubiquitin Ligases in Lung Cancer.Enhanced LPS-induced peritonitis in mice deficiency of cullin 4B in macrophages.E3 ubiquitin ligase Cullin4B mediated polyubiquitination of p53 for its degradation.Dysregulation of the miR-194-CUL4B negative feedback loop drives tumorigenesis in non-small-cell lung carcinoma.A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions.Zebrafish cul4a, but not cul4b, modulates cardiac and forelimb development by upregulating tbx5a expression.Lack of CUL4B leads to increased abundance of GFAP-positive cells that is mediated by PTGDS in mouse brain.

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Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis

http://www.wikidata.org/entity/Q28262931

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2012 nî lūn-bûn

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2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2012 թվականի օգոստոսին հրատարակված գիտական հոդված

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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Essential role of the CUL4B ub ...... ent during mouse embryogenesis

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Essential role of the CUL4B ub ...... ent during mouse embryogenesis

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Essential role of the CUL4B ub ...... ent during mouse embryogenesis

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Essential role of the CUL4B ub ...... ent during mouse embryogenesis

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Essential role of the CUL4B ub ...... ent during mouse embryogenesis

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Essential role of the CUL4B ub ...... ent during mouse embryogenesis

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Essential role of the CUL4B ub ...... ent during mouse embryogenesis

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Essential role of the CUL4B ub ...... ent during mouse embryogenesis

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Elizabeth H Lacy

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Liang Ma

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Lisa Prevedel

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Pengbo Zhou

http://www.w3.org/2001/XMLSchema#string

Yan Yin

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Yuewei Li

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P2860

Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.

Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor

Mutation in CUL4B, which encodes a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardation

CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis

X-linked mental retardation gene CUL4B targets ubiquitylation of H3K4 methyltransferase component WDR5 and regulates neuronal gene expression

An early developmental role for miRNAs in the maintenance of extraembryonic stem cells in the mouse embryo

Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage

Amnion formation in the mouse embryo: the single amniochorionic fold model.

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