Structure and function of a new STAT-induced STAT inhibitor
about
SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradationBruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding proteinp56(dok-2) as a cytokine-inducible inhibitor of cell proliferation and signal transductionThe zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activityIdentification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activationInhibition of Stat1-mediated gene activation by PIAS1Requirement for microtubule integrity in the SOCS1-mediated intracellular dynamics of HIV-1 GagInteraction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptorTwenty proteins containing a C-terminal SOCS box form five structural classesECHS1 interacts with STAT3 and negatively regulates STAT3 signalingVHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligasesCOMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligaseAnkyrin repeat and SOCS box 3 (ASB3) mediates ubiquitination and degradation of tumor necrosis factor receptor IIPrinciples of interleukin (IL)-6-type cytokine signalling and its regulationInterleukin-6-type cytokine signalling through the gp130/Jak/STAT pathwayInterleukin 9 induces expression of three cytokine signal inhibitors: cytokine-inducible SH2-containing protein, suppressor of cytokine signalling (SOCS)-2 and SOCS-3, but only SOCS-3 overexpression suppresses interleukin 9 signallingSocs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferationThe JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loopRegulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interactionDifferential binding to and regulation of JAK2 by the SH2 domain and N-terminal region of SH2-bbetaA Drosophila PIAS homologue negatively regulates stat92ECentral role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouseMast cell homeostasis and the JAK-STAT pathwayA DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/MThe conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradationIdentification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complexActivation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complexEnhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptorSignal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylationOverexpression of PIAS3 suppresses cell growth and restores the drug sensitivity of human lung cancer cells in association with PI3-K/Akt inactivationSignal transducers and activators of transcription as regulators of growth, apoptosis and breast development.Distinct signal transduction processes by IL-4 and IL-13 and influences from the Q551R variant of the human IL-4 receptor alpha chainSignaling by STATsJanus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation.Suppressors of Cytokine Signaling in Sickness and in Health of Pancreatic β-CellsPossible Pharmacological Approach Targeting Endoplasmic Reticulum Stress to Ameliorate Leptin Resistance in ObesityThe role of cullin 5-containing ubiquitin ligasesThe role of small adaptor proteins in the control of oncogenic signalingr driven by tyrosine kinases in human cancer
P2860
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P2860
Structure and function of a new STAT-induced STAT inhibitor
description
1997 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հունիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Nature
@fr
artículu científicu espublizáu en 1997
@ast
scientific journal article
@en
vedecký článok (publikovaný 1997/06/26)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/06/26)
@nl
наукова стаття, опублікована в червні 1997
@uk
مقالة علمية (نشرت في 26-6-1997)
@ar
name
Structure and function of a new STAT-induced STAT inhibitor
@ast
Structure and function of a new STAT-induced STAT inhibitor
@en
Structure and function of a new STAT-induced STAT inhibitor
@nl
type
label
Structure and function of a new STAT-induced STAT inhibitor
@ast
Structure and function of a new STAT-induced STAT inhibitor
@en
Structure and function of a new STAT-induced STAT inhibitor
@nl
prefLabel
Structure and function of a new STAT-induced STAT inhibitor
@ast
Structure and function of a new STAT-induced STAT inhibitor
@en
Structure and function of a new STAT-induced STAT inhibitor
@nl
P2093
P3181
P356
P1433
P1476
Structure and function of a new STAT-induced STAT inhibitor
@en
P2093
K Yoshizaki
N Nishimoto
S Minamoto
T Kishimoto
T Matsumoto
P2888
P304
P3181
P356
10.1038/43219
P407
P577
1997-06-01T00:00:00Z
P5875
P6179
1030838983