Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination
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Lack of MSH2 involvement differentiates V(D)J recombination from other non-homologous end joining eventsEtoposide induces nuclear re-localisation of AIDMSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sitesStructural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activitiesExamination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversificationMSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice.Unique DNA repair gene variations and potential associations with the primary antibody deficiency syndromes IgAD and CVIDAID and somatic hypermutation.Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutationMSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes.DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse.Mechanism and regulation of class switch recombinationProteomic changes during B cell maturation: 2D-DIGE approach.Mismatch-mediated error prone repair at the immunoglobulin genes.Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C biasOn the molecular mechanism of somatic hypermutation of rearranged immunoglobulin genes.AID to overcome the limitations of genomic information.AIDing antibody diversity by error-prone mismatch repair.A role for the MutL mismatch repair Mlh3 protein in immunoglobulin class switch DNA recombination and somatic hypermutation.ATM is required for efficient recombination between immunoglobulin switch regions.Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouseA role for Msh6 but not Msh3 in somatic hypermutation and class switch recombinationDNA repair in antibody somatic hypermutation.Antibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerasesSomatic hypermutation: activation-induced deaminase for C/G followed by polymerase eta for A/T.High-fidelity correction of genomic uracil by human mismatch repair activities.DNA repair genes are selectively mutated in diffuse large B cell lymphomasIdentification of murine B cell lines that undergo somatic hypermutation focused to A:T and G:C residues.Forced expression of AID facilitates the isolation of class switch variants from hybridoma cells.Uracil within DNA: an actor of antiviral immunity.The concerted action of Msh2 and UNG stimulates somatic hypermutation at A . T base pairs.BRILIA: Integrated Tool for High-Throughput Annotation and Lineage Tree Assembly of B-Cell Repertoires.Differential regulation of histone acetylation and generation of mutations in switch regions is associated with Ig class switching.Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks.AID associates with single-stranded DNA with high affinity and a long complex half-life in a sequence-independent manner.Hypermutation at A/T sites during G.U mismatch repair in vitro by human B-cell lysates.Physiological Roles of DNA Double-Strand Breaks.
P2860
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P2860
Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination
description
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im Oktober 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/10/20)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/10/20)
@nl
наукова стаття, опублікована в жовтні 2003
@uk
مقالة علمية (نشرت في 20-10-2003)
@ar
name
Msh2 ATPase activity is essent ...... ent class switch recombination
@ast
Msh2 ATPase activity is essent ...... ent class switch recombination
@en
Msh2 ATPase activity is essent ...... ent class switch recombination
@nl
type
label
Msh2 ATPase activity is essent ...... ent class switch recombination
@ast
Msh2 ATPase activity is essent ...... ent class switch recombination
@en
Msh2 ATPase activity is essent ...... ent class switch recombination
@nl
prefLabel
Msh2 ATPase activity is essent ...... ent class switch recombination
@ast
Msh2 ATPase activity is essent ...... ent class switch recombination
@en
Msh2 ATPase activity is essent ...... ent class switch recombination
@nl
P2093
P2860
P356
P1476
Msh2 ATPase activity is essent ...... ent class switch recombination
@en
P2093
Alberto Martin
Diana P. Lin
Maria D. Iglesias-Ussel
Matthew D. Scharff
Philip D. Bardwell
Winfried Edelmann
Ziqiang Li
P2860
P304
P356
10.1084/JEM.20030880
P407
P577
2003-10-20T00:00:00Z