A partial loss of function allele of methyl-CpG-binding protein 2 predicts a human neurodevelopmental syndrome
about
Pathogenesis of lethal cardiac arrhythmias in Mecp2 mutant mice: implication for therapy in Rett syndromeLoss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalitiesReciprocal co-regulation of EGR2 and MECP2 is disrupted in Rett syndrome and autismMECP2 disorders: from the clinic to mice and backIssues related to symptomatic and disease-modifying treatments affecting cognitive and neuropsychiatric comorbidities of epilepsyCrh and Oprm1 mediate anxiety-related behavior and social approach in a mouse model of MECP2 duplication syndromeDysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypesUnexpected cellular players in Rett syndrome pathologySensory processing in autism spectrum disorders and Fragile X syndrome-From the clinic to animal models.Behavioural abnormalities in a novel mouse model for Silver Russell Syndrome.Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expressionLoss of MeCP2 in Parvalbumin-and Somatostatin-Expressing Neurons in Mice Leads to Distinct Rett Syndrome-like PhenotypesDeficits in social behavioral tests in a mouse model of alternating hemiplegia of childhood.Repetitive grooming and sensorimotor abnormalities in an ephrin-A knockout model for Autism Spectrum DisordersInduced gamma oscillations differentiate familiar and novel voices in children with MECP2 duplication and Rett syndromes.Insulinotropic treatments exacerbate metabolic syndrome in mice lacking MeCP2 function.Mild expression differences of MECP2 influencing aggressive social behavior.Female Mecp2(+/-) mice display robust behavioral deficits on two different genetic backgrounds providing a framework for pre-clinical studies.Beyond Widespread Mecp2 Deletions to Model Rett Syndrome: Conditional Spatio-Temporal Knockout, Single-Point Mutations and Transgenic Rescue MiceRett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responsesAre NCAM deficient mice an animal model for schizophrenia?Long-lived epigenetic interactions between perinatal PBDE exposure and Mecp2308 mutation.Preclinical research in Rett syndrome: setting the foundation for translational success.Mice with an isoform-ablating Mecp2 exon 1 mutation recapitulate the neurologic deficits of Rett syndrome.Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains.Autism and other neuropsychiatric symptoms are prevalent in individuals with MeCP2 duplication syndrome.MeCP2 reinforces STAT3 signaling and the generation of effector CD4+ T cells by promoting miR-124-mediated suppression of SOCS5.Effect of Sarizotan, a 5-HT1a and D2-like receptor agonist, on respiration in three mouse models of Rett syndromeMeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulantsPostnatal inactivation reveals enhanced requirement for MeCP2 at distinct age windows.A partial MECP2 duplication in a mildly affected adult male: a putative role for the 3' untranslated region in the MECP2 duplication phenotype.MeCP2-mediated transcription repression in the basolateral amygdala may underlie heightened anxiety in a mouse model of Rett syndromeExperimental models of Rett syndrome based on Mecp2 dysfunction.Characterization of the MeCP2R168X knockin mouse model for Rett syndrome.Improving a designed photocontrolled DNA-binding proteinComplexities of Rett syndrome and MeCP2Persistent pain maintains morphine-seeking behavior after morphine withdrawal through reduced MeCP2 repression of GluA1 in rat central amygdala.Intrauterine inflammation, insufficient to induce parturition, still evokes fetal and neonatal brain injuryMeCP2 is critical within HoxB1-derived tissues of mice for normal lifespanTreatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na+-channel-blocking antiepileptic drugs.
P2860
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P2860
A partial loss of function allele of methyl-CpG-binding protein 2 predicts a human neurodevelopmental syndrome
description
2008 nî lūn-bûn
@nan
2008 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մարտին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
A partial loss of function all ...... an neurodevelopmental syndrome
@ast
A partial loss of function all ...... an neurodevelopmental syndrome
@en
A partial loss of function all ...... an neurodevelopmental syndrome
@nl
type
label
A partial loss of function all ...... an neurodevelopmental syndrome
@ast
A partial loss of function all ...... an neurodevelopmental syndrome
@en
A partial loss of function all ...... an neurodevelopmental syndrome
@nl
prefLabel
A partial loss of function all ...... an neurodevelopmental syndrome
@ast
A partial loss of function all ...... an neurodevelopmental syndrome
@en
A partial loss of function all ...... an neurodevelopmental syndrome
@nl
P2093
P2860
P50
P3181
P356
P1476
A partial loss of function all ...... an neurodevelopmental syndrome
@en
P2093
Hsiao-Tuan Chao
John D Fryer
John J Greer
Sharyl Fyffe
Yaling Sun
P2860
P304
P3181
P356
10.1093/HMG/DDN062
P577
2008-03-04T00:00:00Z