Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction.
about
A yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor proteinSuppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signalingThe E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteinsAnkyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradationPrinciples of interleukin (IL)-6-type cytokine signalling and its regulationSOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardationExpression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiationSelective regulatory function of Socs3 in the formation of IL-17-secreting T cellsInhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domainDifferential binding to and regulation of JAK2 by the SH2 domain and N-terminal region of SH2-bbetaMast cell homeostasis and the JAK-STAT pathwayThe conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradationTwo Drosophila suppressors of cytokine signaling (SOCS) differentially regulate JAK and EGFR pathway activitiesThe role of suppressors of cytokine signalling in human neoplasmsStructure of the SOCS4-ElonginB/C Complex Reveals a Distinct SOCS Box Interface and the Molecular Basis for SOCS-Dependent EGFR DegradationThe SOCS Box Domain of SOCS3: Structure and Interaction with the ElonginBC-Cullin5 Ubiquitin LigaseStructural Basis for c-KIT Inhibition by the Suppressor of Cytokine Signaling 6 (SOCS6) Ubiquitin LigaseSOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibitionStimulation of leukemia inhibitory factor receptor degradation by extracellular signal-regulated kinaseCIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domainInhibition and restoration of prolactin signal transduction by suppressors of cytokine signalingSuppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistanceSHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130Cytokine signaling in the brain: putting a SOCS in it?Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signalingExpression of suppressors of cytokine signaling during liver regenerationSOCS2 negatively regulates growth hormone action in vitro and in vivoSuppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signalingThe SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivoSuppressor of cytokine signaling 2 regulates neuronal differentiation by inhibiting growth hormone signalingPim serine/threonine kinases regulate the stability of Socs-1 proteinTyrosine-phosphorylated SOCS3 interacts with the Nck and Crk-L adapter proteins and regulates Nck activation.Transcriptional activation of the suppressor of cytokine signaling-3 (SOCS-3) gene via STAT3 is increased in F9 REX1 (ZFP-42) knockout teratocarcinoma stem cells relative to wild-type cellsCellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenzaASB9 interacts with ubiquitous mitochondrial creatine kinase and inhibits mitochondrial functionSuppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.Gene expression profiling of long-lived dwarf mice: longevity-associated genes and relationships with diet, gender and aging.Intracellular delivery of a cell-penetrating SOCS1 that targets IFN-gamma signaling.A new polycythaemia vera-associated SOCS3 SH2 mutant (SOCS3F136L) cannot regulate erythropoietin responses
P2860
Q24299850-1D6AE198-C1E8-4D23-964B-BDC7E868086DQ24321251-4E6A1EAD-6522-4D82-9B7D-FC3966B23CF6Q24321847-B5F3B27F-A503-4BFA-94DC-CB273BC1F48BQ24322983-C97AD02E-4706-4C9F-B88A-626362451F74Q24530173-3381BB8D-146A-4DF9-A487-E320649FFAA4Q24537559-E5C57FC1-3D45-4F24-9555-49CEE2974073Q24538645-1669FB97-4C3F-4086-9D7B-8CBDA245BFD2Q24547568-23E057B9-04E7-48EC-9896-97CC2AA56BB7Q24551173-22A187BE-1A8E-4FD2-B1F9-FE9A03AEAB7DQ24554240-8DA4E9D7-507C-44FD-B918-DFDE486466FEQ24632515-D90BD78D-11E8-4562-8507-9768C5F62FE5Q24654107-4F281EB7-1976-4C75-A610-557D119C1376Q24792628-7A1F86C4-FA9A-481B-9645-53744107A9F5Q27026783-EEDBD9F1-83F3-42E6-ADAF-DBAA1993DEEDQ27649020-A81BD22A-DC82-4EB6-9860-1D5876E1A777Q27651007-6EE423CC-F310-475C-BA2C-735219AF0F46Q27665424-23F3E5A9-27DB-4969-B94A-524FCA9A8494Q27676669-F03AB80E-7B66-4714-A119-713DADBC5629Q28138574-A6BF8FAA-4E22-47E4-B26C-8B0004ED57D8Q28140132-33A831A7-8047-4FBA-BABA-A7B898148A72Q28140535-0015E79C-8ED9-43AA-8A83-F80456F853F5Q28142615-57AC9839-1BD1-4C9C-BF4A-0B61EB78D970Q28187852-CFCC5CD2-FDFB-46B0-A3B7-962455B6021FQ28211408-B631B466-FEB6-4C72-A6EC-87D702BFE6F7Q28218029-8FB79314-7A44-418C-A5BE-7E1BEFA92355Q28237281-249B5AEF-AE90-4FFD-BA20-B5E9284E06EFQ28365891-9102FA6B-A324-4DB1-B772-86DE337A6017Q28508170-658FF9A6-45C3-479C-B9C7-12ACF7E8F63DQ28585800-A6EA8CD2-EC39-4C42-A08F-8C4A97D30CABQ28588059-814BDB18-D6B7-40A7-89CB-6C5E4597381DQ28589965-4C25C9AA-1ADE-4725-9290-56EC95BE0B6DQ28594323-3AF816F8-0EB7-4B8B-A56F-6EDC07CAB82DQ30164048-99F094E6-7FB0-4E39-B99B-04BBD5CFEA2BQ30176405-7DC9FDE1-7DCD-41E1-BFE3-661B74D7B662Q30331304-0A648DA8-92CE-412A-8C5A-0D2BF404D4A1Q30494036-709F9E07-EAAF-46FA-9CBE-BAD697B22618Q31130829-03CBA79D-6C3D-4616-A859-8B4DB4B0BC54Q33301487-952CA87C-D638-4B37-9131-2CB960E20E94Q33560131-976982B9-7E6E-4790-8E53-F5640C81EBA3Q33726144-E7B2EE31-5B0B-4FB6-B579-1FED36EC6A11
P2860
Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction.
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Mutational analyses of the SOC ...... F and IL-6 signal transduction
@nl
Mutational analyses of the SOC ...... and IL-6 signal transduction.
@ast
Mutational analyses of the SOC ...... and IL-6 signal transduction.
@en
type
label
Mutational analyses of the SOC ...... F and IL-6 signal transduction
@nl
Mutational analyses of the SOC ...... and IL-6 signal transduction.
@ast
Mutational analyses of the SOC ...... and IL-6 signal transduction.
@en
prefLabel
Mutational analyses of the SOC ...... F and IL-6 signal transduction
@nl
Mutational analyses of the SOC ...... and IL-6 signal transduction.
@ast
Mutational analyses of the SOC ...... and IL-6 signal transduction.
@en
P2093
P2860
P356
P1433
P1476
Mutational analyses of the SOC ...... and IL-6 signal transduction.
@en
P2093
D J Hilton
N A Nicola
S E Nicholson
T A Willson
W S Alexander
P2860
P304
P356
10.1093/EMBOJ/18.2.375
P407
P577
1999-01-01T00:00:00Z