WASH knockout T cells demonstrate defective receptor trafficking, proliferation, and effector function
about
The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIαVARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surfaceIdentification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recyclingEndosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia.RME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation.Vesicular Trafficking to the Immune Synapse: How to Assemble Receptor-Tailored Pathways from a Basic Building SetT Lymphocyte Migration: An Action Movie Starring the Actin and Associated Actors.Function and regulation of the endosomal fusion and fission machineriesThe spectrum of KIAA0196 variants, and characterization of a murine knockout: implications for the mutational mechanism in hereditary spastic paraplegia type SPG8.Phosphoinositide binding by the SNX27 FERM domain regulates its localization at the immune synapse of activated T-cells.Retromer-mediated endosomal protein sorting: all WASHed up!Dendritic cells utilize the evolutionarily conserved WASH and retromer complexes to promote MHCII recycling and helper T cell primingMutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagyWash functions downstream of Rho1 GTPase in a subset of Drosophila immune cell developmental migrations.WASH maintains NKp46+ ILC3 cells by promoting AHR expression.WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.Retromer: a master conductor of endosome sorting.Nuclear FAM21 participates in NF-κB-dependent gene regulation in pancreatic cancer cells.SNX17 affects T cell activation by regulating TCR and integrin recyclingHkRP3 is a microtubule-binding protein regulating lytic granule clustering and NK cell killing.WASH is required for lysosomal recycling and efficient autophagic and phagocytic digestion.WASH has a critical role in NK cell cytotoxicity through Lck-mediated phosphorylationWASH drives early recycling from macropinosomes and phagosomes to maintain surface phagocytic receptorsRetromer- and WASH-dependent sorting of nutrient transporters requires a multivalent interaction network with ANKRD50.Orchestrating cytoskeleton and intracellular vesicle traffic to build functional immunological synapses.Actin cytoskeleton control of the comings and goings of T lymphocytes.Regulation of vesicular traffic at the T cell immune synapse: lessons from the primary cilium.The T cell IFT20 interactome reveals new players in immune synapse assembly.The emerging role of retromer in neuroprotection.Arp2/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCR+ endosome traffickingRole of the EHD Family of Endocytic Recycling Regulators for TCR Recycling and T Cell Function.Actin assembly mechanisms at a glance.Arp2/3 Complex Is Required for Macrophage Integrin Functions but Is Dispensable for FcR Phagocytosis and In Vivo Motility.The spectrum of T cell metabolism in health and disease.Endosomal Receptor Trafficking: Retromer and Beyond.Wash exhibits context-dependent phenotypes and, along with the WASH regulatory complex, regulates Drosophila oogenesis.
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P2860
WASH knockout T cells demonstrate defective receptor trafficking, proliferation, and effector function
description
2013 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2013
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im März 2013 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2013/03/01)
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vědecký článek publikovaný v roce 2013
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wetenschappelijk artikel (gepubliceerd op 2013/03/01)
@nl
наукова стаття, опублікована в березні 2013
@uk
مقالة علمية (نشرت في مارس 2013)
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name
WASH knockout T cells demonstr ...... eration, and effector function
@ast
WASH knockout T cells demonstr ...... eration, and effector function
@en
WASH knockout T cells demonstr ...... eration, and effector function
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type
label
WASH knockout T cells demonstr ...... eration, and effector function
@ast
WASH knockout T cells demonstr ...... eration, and effector function
@en
WASH knockout T cells demonstr ...... eration, and effector function
@nl
prefLabel
WASH knockout T cells demonstr ...... eration, and effector function
@ast
WASH knockout T cells demonstr ...... eration, and effector function
@en
WASH knockout T cells demonstr ...... eration, and effector function
@nl
P2093
P2860
P3181
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P1476
WASH knockout T cells demonstr ...... eration, and effector function
@en
P2093
Daniel D Billadeau
Joshua T Piotrowski
Renee A Schoon
Timothy S Gomez
P2860
P304
P3181
P356
10.1128/MCB.01288-12
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P577
2012-12-28T00:00:00Z