ATR disruption leads to chromosomal fragmentation and early embryonic lethality
about
ATR suppresses endogenous DNA damage and allows completion of homologous recombination repairA mouse model of ATR-Seckel shows embryonic replicative stress and accelerated agingHuman Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpointThe DNA damage pathway regulates innate immune system ligands of the NKG2D receptorTumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activationInteraction between human MCM7 and Rad17 proteins is required for replication checkpoint signalingATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylationActivation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firingA DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1BRCT domain-containing protein PTIP is essential for progression through mitosisPhosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damageFunctional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stressChk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpointTargeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugsMore than blood, a novel gene required for mammalian postimplantation developmentThe replication fork: understanding the eukaryotic replication machinery and the challenges to genome duplicationG2E3 is a dual function ubiquitin ligase required for early embryonic developmentThe combined status of ATM and p53 link tumor development with therapeutic responseCommon mechanisms of PIKK regulationSimian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 bindingAtaxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitroCep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1Essential and dispensable roles of ATR in cell cycle arrest and genome maintenanceG2E3 is a nucleo-cytoplasmic shuttling protein with DNA damage responsive localizationThe human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilonMutation analysis of the ATR gene in breast and ovarian cancer families.Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapyATR-mediated regulation of nuclear and cellular plasticityDNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of CancerThe current state of eukaryotic DNA base damage and repairTargeting the Checkpoint to Kill Cancer CellsModeling the study of DNA damage responses in miceResistance and gain-of-resistance phenotypes in cancers harboring wild-type p53Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenanceATR mutation in endometrioid endometrial cancer is associated with poor clinical outcomes.Preventing replication fork collapse to maintain genome integrityHistone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stressCellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insightsDeletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss
P2860
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P2860
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
description
2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2000
@ast
im Februar 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/02/15)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/02/15)
@nl
наукова стаття, опублікована в лютому 2000
@uk
مقالة علمية (نشرت في 15-2-2000)
@ar
name
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
@ast
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
@en
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
@nl
type
label
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
@ast
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
@en
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
@nl
prefLabel
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
@ast
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
@en
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
@nl
P2860
P3181
P356
P1433
P1476
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
@en
P2093
D. Baltimore
E. J. Brown
P2860
P304
P3181
P356
10.1101/GAD.14.4.397
P577
2000-02-15T00:00:00Z