A role for ATR in the DNA damage-induced phosphorylation of p53
about
Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activityCloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testesCamptothecin-induced downregulation of MLL5 contributes to the activation of tumor suppressor p53G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosisBARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinaseGlioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressorHLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p5314-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activationPost-transcriptional regulation of thioredoxin by the stress inducible heterogenous ribonucleoprotein A18.Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genesTip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression.Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damagePPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpointsUV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalizationStress-dependent nucleolin mobilization mediated by p53-nucleolin complex formationA DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damageDirect regulation of CREB transcriptional activity by ATM in response to genotoxic stressFunctional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stressChk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpointThe human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sitesChk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53Targeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugsAtaxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitroInvolvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damageEssential and dispensable roles of ATR in cell cycle arrest and genome maintenanceRapid activation of ATR by ionizing radiation requires ATM and Mre11Glycerol restores heat-induced p53-dependent apoptosis of human glioblastoma cells bearing mutant p53Oncogenic MicroRNAs: Key Players in Malignant TransformationInvolvement of p53 in the repair of DNA double strand breaks: multifaceted Roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ)ATR mutation in endometrioid endometrial cancer is associated with poor clinical outcomes.Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase.p53 Acetylation: Regulation and ConsequencesATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responsesRegulatory interactions between the checkpoint kinase Chk1 and the proteins of the DNA-dependent protein kinase complexAtaxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodiesChecking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressorPlk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway
P2860
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P2860
A role for ATR in the DNA damage-induced phosphorylation of p53
description
1999 nî lūn-bûn
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1999 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունվարին հրատարակված գիտական հոդված
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1999年の論文
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1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
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1999年论文
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name
A role for ATR in the DNA damage-induced phosphorylation of p53
@ast
A role for ATR in the DNA damage-induced phosphorylation of p53
@en
A role for ATR in the DNA damage-induced phosphorylation of p53
@en-gb
A role for ATR in the DNA damage-induced phosphorylation of p53
@nl
type
label
A role for ATR in the DNA damage-induced phosphorylation of p53
@ast
A role for ATR in the DNA damage-induced phosphorylation of p53
@en
A role for ATR in the DNA damage-induced phosphorylation of p53
@en-gb
A role for ATR in the DNA damage-induced phosphorylation of p53
@nl
prefLabel
A role for ATR in the DNA damage-induced phosphorylation of p53
@ast
A role for ATR in the DNA damage-induced phosphorylation of p53
@en
A role for ATR in the DNA damage-induced phosphorylation of p53
@en-gb
A role for ATR in the DNA damage-induced phosphorylation of p53
@nl
P2093
P2860
P921
P3181
P356
P1433
P1476
A role for ATR in the DNA damage-induced phosphorylation of p53
@en
P2093
J M Williams
J N Sarkaria
K M Brumbaugh
R S Tibbetts
R T Abraham
P2860
P3181
P356
10.1101/GAD.13.2.152
P407
P577
1999-01-15T00:00:00Z