Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice
about
Mood disorders in Huntington's disease: from behavior to cellular and molecular mechanismsHuntingtin is critical both pre- and postsynaptically for long-term learning-related synaptic plasticity in AplysiaOligonucleotide therapeutic approaches for Huntington diseaseHuntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitorsRecruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner HippiA Drosophila homolog of the polyglutamine disease gene SCA2 is a dosage-sensitive regulator of actin filament formationHuntingtin in health and diseaseCongenital hydrocephalus associated with abnormal subcommissural organ in mice lacking huntingtin in Wnt1 cell lineagesCAG expansion in the Huntington disease gene is associated with a specific and targetable predisposing haplogroupStimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factorPost-Translational Modifications of Histones in Vertebrate NeurogenesisNeural and mesenchymal stem cells in animal models of Huntington's disease: past experiences and future challengesThe Function of Autophagy in Neurodegenerative DiseasesIron dysregulation in Huntington's diseaseHuntington's disease: the past, present, and future search for disease modifiers.Intrabodies as neuroprotective therapeuticsAntisense oligonucleotides: treating neurodegeneration at the level of RNAHuntingtin Is Required for Epithelial Polarity through RAB11A-Mediated Apical Trafficking of PAR3-aPKCHuntingtin's function in axonal transport is conserved in Drosophila melanogasterMultiple organ system defects and transcriptional dysregulation in the Nipbl(+/-) mouse, a model of Cornelia de Lange SyndromeHuntingtin functions as a scaffold for selective macroautophagyHuntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survivalHuntingtin and its role in neuronal degenerationNormal huntingtin function: an alternative approach to Huntington's diseaseGenetic interaction between expanded murine Hdh alleles and p53 reveal deleterious effects of p53 on Huntington's disease pathogenesisDeletion of the triplet repeat encoding polyglutamine within the mouse Huntington's disease gene results in subtle behavioral/motor phenotypes in vivo and elevated levels of ATP with cellular senescence in vitroAllele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patientsHuntingtin inhibits caspase-3 activationThe Huntington's disease mutation impairs Huntingtin's role in the transport of NF-κB from the synapse to the nucleus.Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitroPartial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesisTargeting several CAG expansion diseases by a single antisense oligonucleotidePotential function for the Huntingtin protein as a scaffold for selective autophagy.Is Huntingtin Dispensable in the Adult Brain?Ablation of huntingtin in adult neurons is nondeleterious but its depletion in young mice causes acute pancreatitis.N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy.Forebrain-Specific Loss of BMPRII in Mice Reduces Anxiety and Increases Object Exploration.Huntingtin is required for normal excitatory synapse development in cortical and striatal circuitsForebrain HCN1 channels contribute to hypnotic actions of ketamine.
P2860
Q21131050-0658BE47-BF16-42EB-8DC1-57F9B4188E57Q21131986-BB2EF04F-3862-479C-A72F-A879462CBCB6Q22306293-D0B827BF-B297-46AF-8123-9A0A822590F8Q24291803-2234984C-B06F-485C-84CB-7ED3BF7E59F4Q24292161-4B01E341-9857-4A56-A137-C851E0FA18F2Q24543178-96983A19-6746-44C0-AB61-15A9FBF0E46EQ24554374-F1E9AEDB-D121-4E81-8D77-74D510F90036Q24619721-0BCC6EFF-C6D1-49FE-853F-8872D6BCFE31Q24644358-FA106A35-2A59-4C7C-9858-4EB9B0DA7B74Q24681194-25E4D20A-BCBE-46D6-A227-66CA0E1D548FQ24799224-A06D599F-4146-4963-87EA-3D92668C7463Q26770764-54C4162F-2EE5-4360-A16E-D185A93F069BQ26775932-41D50C22-377D-4E0E-924D-1067BC33D115Q26777018-FB5704FF-752B-45C6-87E1-FDB407C533EDQ26829932-F27783BE-AB4A-424D-87AB-BA7192E198B0Q26830039-9D0B1507-2592-4941-A8C2-0CA951F2A867Q27003896-53BEBFA5-E77A-425C-A9FB-604E4D0AB202Q27007056-C871C72A-54BA-4794-9984-BB44A98E40F0Q27312162-4AAF0DF1-06E8-4C2F-B05A-B4792DFAFF41Q27331461-E3CBD883-93EC-402F-91CF-FCE1DE7BF8A8Q27349033-267A8AC9-C80A-4018-BCBB-5FB2A4260655Q28118022-6E9CF1F9-8DB5-46DD-8600-5C137C3BF001Q28217008-54847EB3-2CB6-4113-85DF-0096F081553CQ28281434-6EA81DD7-05D0-4F1F-9675-05AA0C345ABFQ28281904-EEDBB64E-2829-4AFB-A43C-4FEB63C73E6CQ28507529-566B8729-9DAE-4559-AA70-CC3FCAEF743AQ28510315-E1DF802E-8D46-47D1-AAEB-ADB9D7F6CC5BQ28542911-424F956F-B73F-4D4F-871C-393EFB964D32Q28566357-1E3E5368-94F7-45AD-A54D-D9FF30F49188Q28571426-75CFD687-220C-460D-BFC3-E2AF4DE28380Q28584697-93469002-4E25-4784-8393-C5E214C89933Q28593098-380BD71E-36DA-4112-B59C-DE605AB0B4D3Q28740870-9CB762A8-DD73-4614-8B38-5C96B5269E70Q30301372-D0442927-DFD3-4DD1-ACEB-EF0B907EDE53Q30353134-B8F5821C-EF16-44AC-8CDB-153CEA4A5134Q30356472-0481A891-B934-4BAC-8C4D-3232DCAF81F7Q30358344-FA7CBF60-3235-4F86-B261-4DDB623D8C93Q30400940-B54580B2-BC39-41F8-8832-B51F889576A0Q30408636-17FFEDA6-700E-4E7F-A514-127215107586Q30413959-478AED02-5B90-45C9-B183-3F75A80E102E
P2860
Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice
description
2000 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
articolo scientifico
@it
artículu científicu espublizáu en 2000
@ast
im November 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/11/01)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/11/01)
@nl
наукова стаття, опублікована в листопаді 2000
@uk
name
Inactivation of Hdh in the bra ...... neration and sterility in mice
@ast
Inactivation of Hdh in the bra ...... neration and sterility in mice
@en
Inactivation of Hdh in the bra ...... neration and sterility in mice
@nl
type
label
Inactivation of Hdh in the bra ...... neration and sterility in mice
@ast
Inactivation of Hdh in the bra ...... neration and sterility in mice
@en
Inactivation of Hdh in the bra ...... neration and sterility in mice
@nl
prefLabel
Inactivation of Hdh in the bra ...... neration and sterility in mice
@ast
Inactivation of Hdh in the bra ...... neration and sterility in mice
@en
Inactivation of Hdh in the bra ...... neration and sterility in mice
@nl
P2093
P3181
P356
P1433
P1476
Inactivation of Hdh in the bra ...... neration and sterility in mice
@en
P2093
I. Dragatsis
M. S. Levine
S. Zeitlin
P2888
P304
P3181
P356
10.1038/81593
P407
P577
2000-11-01T00:00:00Z