Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts
about
TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike proteinIdentification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, and Nipah viruses by using a novel high-throughput screening assayHuman coronavirus EMC does not require the SARS-coronavirus receptor and maintains broad replicative capability in mammalian cell linesProteolytic activation of the SARS-coronavirus spike protein: cutting enzymes at the cutting edge of antiviral research.Tmprss2 is essential for influenza H1N1 virus pathogenesis in mice.DESC1 and MSPL activate influenza A viruses and emerging coronaviruses for host cell entry.Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza.Pseudotype-based neutralization assays for influenza: a systematic analysis.Matriptase proteolytically activates influenza virus and promotes multicycle replication in the human airway epithelium.The host protease TMPRSS2 plays a major role in in vivo replication of emerging H7N9 and seasonal influenza viruses.Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin.TMPRSS2 and MSPL Facilitate Trypsin-Independent Porcine Epidemic Diarrhea Virus Replication in Vero Cells.Respiratory protease/antiprotease balance determines susceptibility to viral infection and can be modified by nutritional antioxidantsThe human Transmembrane Protease Serine 2 is necessary for the production of Group 2 influenza A virus pseudotypes.The Proteolytic Activation of (H3N2) Influenza A Virus Hemagglutinin Is Facilitated by Different Type II Transmembrane Serine Proteases.The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies.Middle East respiratory syndrome coronavirus infection mediated by the transmembrane serine protease TMPRSS2.High TMPRSS11D protein expression predicts poor overall survival in non-small cell lung cancer.Activation of influenza viruses by proteases from host cells and bacteria in the human airway epithelium.The oncogene ERG: a key factor in prostate cancer.TMPRSS2 Isoform 1 Activates Respiratory Viruses and Is Expressed in Viral Target Cells.Identification and characterization of a proteolytically primed form of the murine coronavirus spike proteins after fusion with the target cell.Human airway trypsin-like protease, a serine protease involved in respiratory diseases.Coronavirus and influenza virus proteolytic priming takes place in tetraspanin-enriched membrane microdomainsModification of the hemagglutinin cleavage site allows indirect activation of avian influenza virus H9N2 by bacterial staphylokinaseActivation of influenza A viruses by host proteases from swine airway epitheliumProteolytic activation of the porcine epidemic diarrhea coronavirus spike fusion protein by trypsin in cell culture.Influenza A Virus Cell Entry, Replication, Virion Assembly and MovementTMPRSS11A activates the influenza A virus hemagglutinin and the MERS coronavirus spike protein and is insensitive against blockade by HAI-1Exchange of amino acids in the H1-haemagglutinin to H3 residues is required for efficient influenza A virus replication and pathology in Tmprss2 knock-out mice
P2860
Q24339582-AE16B358-2773-46BF-BBDB-44BA72B51B97Q24567771-0D039A1D-5047-473A-82D3-3A4290281384Q24600523-4766014B-0ECB-4F47-A8F5-8E74E23CB590Q30354466-5224628C-EC7B-4E0E-A598-5828209BAD37Q30356975-745A7A64-4F27-4951-9F03-8A2335DB9233Q30365699-19A4619D-748D-4707-8730-6D342A267D38Q30374069-70D58326-A5A7-43D1-A68F-6DDE86298797Q30374662-B21C3184-DBA8-4CD7-9C14-9C053A7DD517Q30426551-A87C010C-ADF9-42D2-8081-3B43CACC1D9FQ33602849-5007C33E-CA28-493F-BA4D-765AA0D297C7Q33663432-CB63E573-2D6D-45F1-B9C4-55BF7E4997B1Q33753975-1C2BC3B0-D8DF-42EB-B15C-6A8AE60A1253Q36104532-1AB9C684-C6C1-4B1B-94F9-018B37752A34Q36734159-32EA16A2-168E-4F97-969C-873B3E4240BBQ36811980-02DC5C14-2C89-4C3F-A6B3-E11E420A3873Q36827306-25C5F115-EA86-4100-9928-521531E658D6Q37336487-705E88C6-4155-491D-AD0F-35D2AF82829DQ37706501-983F4DE6-530A-49A1-BCF8-CB5D7C416589Q38118946-C1C62DAB-4724-4A25-B9A2-E1BC113A5CFAQ38444138-BE080EDB-4F4B-47A9-82E8-D4C4505F804BQ38834744-39B0F907-421C-45E3-8853-3C70E2B5CFF1Q38860071-A1BEF141-42B7-4BFD-9719-81A21469C021Q39149977-5AE1270B-EA19-47E0-80DF-7386B7DE99A9Q41014846-450040E9-8F20-4506-8141-0613BB590288Q41357037-E9832BF6-FB37-4BE8-B8B4-95DD927A9E54Q41820530-5783C29F-72FA-4DAA-9995-EE11C162F8FCQ41975503-C87EA0D1-A812-49D1-8188-1DDAD216AE4BQ56981340-ECFD76DF-D903-4A17-8EA3-10CA31AAAE53Q57252412-CFD039CD-3869-4D9A-AE4B-C068E0D4B8E9Q58690963-29E8FFE0-E4A6-4874-8345-9C81291786FD
P2860
Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Influenza and SARS-coronavirus ...... ry and gastrointestinal tracts
@ast
Influenza and SARS-coronavirus ...... ry and gastrointestinal tracts
@en
Influenza and SARS-coronavirus ...... ry and gastrointestinal tracts
@nl
type
label
Influenza and SARS-coronavirus ...... ry and gastrointestinal tracts
@ast
Influenza and SARS-coronavirus ...... ry and gastrointestinal tracts
@en
Influenza and SARS-coronavirus ...... ry and gastrointestinal tracts
@nl
prefLabel
Influenza and SARS-coronavirus ...... ry and gastrointestinal tracts
@ast
Influenza and SARS-coronavirus ...... ry and gastrointestinal tracts
@en
Influenza and SARS-coronavirus ...... ry and gastrointestinal tracts
@nl
P2093
P2860
P50
P1433
P1476
Influenza and SARS-coronavirus ...... ry and gastrointestinal tracts
@en
P2093
Adeline Heurich
Jared M Lucas
Paula Perin
Peter S Nelson
Simon Danisch
Stefanie Gierer
Stephanie Bertram
P2860
P304
P356
10.1371/JOURNAL.PONE.0035876
P407
P577
2012-04-30T00:00:00Z