Structural basis of PROTAC cooperative recognition for selective protein degradation
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Structure-Guided Design of Peptides as Tools to Probe the Protein-Protein Interaction between Cullin-2 and Elongin BC Substrate Adaptor in Cullin RING E3 Ubiquitin LigasesImpact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds.Targeted protein knockdown using small molecule degraders.Targeted Protein Degradation: from Chemical Biology to Drug Discovery.Brd4-Brd2 isoform switching coordinates pluripotent exit and Smad2-dependent lineage specification.Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation.Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766).Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead.The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study.Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders.Electrochemically Enabled, Nickel-Catalyzed Amination.Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-2.Thioamide substitution to probe the hydroxyproline recognition of VHL ligands.Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands.Bromodomain protein BRD4 inhibitor JQ1 regulates potential prognostic molecules in advanced renal cell carcinoma.BET inhibition overcomes receptor tyrosine kinase-mediated cetuximab resistance in HNSCC.Small Molecule Modulators of RING-Type E3 Ligases: MDM and Cullin Families as Targets.Optimization of a "bump-and-hole" approach to allele-selective BET bromodomain inhibition.Worldwide Protein Data Bank validation information: usage and trends.Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin LigaseSmall-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugsPharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase
P2860
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P2860
Structural basis of PROTAC cooperative recognition for selective protein degradation
description
2017 nî lūn-bûn
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2017年の論文
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2017年学术文章
@wuu
2017年学术文章
@zh-cn
2017年学术文章
@zh-hans
2017年学术文章
@zh-my
2017年学术文章
@zh-sg
2017年學術文章
@yue
2017年學術文章
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2017年學術文章
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name
Structural basis of PROTAC cooperative recognition for selective protein degradation
@ast
Structural basis of PROTAC cooperative recognition for selective protein degradation
@en
type
label
Structural basis of PROTAC cooperative recognition for selective protein degradation
@ast
Structural basis of PROTAC cooperative recognition for selective protein degradation
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prefLabel
Structural basis of PROTAC cooperative recognition for selective protein degradation
@ast
Structural basis of PROTAC cooperative recognition for selective protein degradation
@en
P2093
P2860
P50
P356
P1476
Structural basis of PROTAC cooperative recognition for selective protein degradation
@en
P2093
Andrea Testa
Douglas J Lamont
Kwok-Ho Chan
Michael Zengerle
Wenzhang Chen
P2860
P2888
P304
P356
10.1038/NCHEMBIO.2329
P577
2017-03-13T00:00:00Z