about
Toward high-resolution homology modeling of antibody Fv regions and application to antibody-antigen dockingAn Integrated Framework Advancing Membrane Protein Modeling and DesignThe structural and energetic basis for high selectivity in a high-affinity protein-protein interactionComputational design of an endo-1,4- -xylanase ligand binding siteNovel peptide-mediated interactions derived from high-resolution 3-dimensional structuresBeauty is in the eye of the beholder: proteins can recognize binding sites of homologous proteins in more than one wayAffinity- and specificity-enhancing mutations are frequent in multispecific interactions between TIMP2 and MMPsMulti-constraint computational design suggests that native sequences of germline antibody H3 loops are nearly optimal for conformational flexibilityComputational protein design quantifies structural constraints on amino acid covariationPrediction of mutational tolerance in HIV-1 protease and reverse transcriptase using flexible backbone protein designPredicting the tolerated sequences for proteins and protein interfaces using RosettaBackrub flexible backbone designRosettaBackrub--a web server for flexible backbone protein structure modeling and designPractically useful: what the Rosetta protein modeling suite can do for youSpecificity in computational protein designComputed structures of point deletion mutants and their enzymatic activities.Modular organization and combinatorial energetics of proline-tyrosine nuclear localization signalsA computational framework to empower probabilistic protein designExploring functional roles of multibinding protein interfaces.Tradeoff between stability and multispecificity in the design of promiscuous proteins.Identification of structural mechanisms of HIV-1 protease specificity using computational peptide docking: implications for drug resistance.Approaches for probing the sequence space of substrates recognized by molecular chaperonesStructure collisions between interacting proteinsA generic program for multistate protein design.Computational design of second-site suppressor mutations at protein-protein interfacesIntrinsic disorder and protein multibinding in domain, terminal, and linker regionsConformational stabilization of ubiquitin yields potent and selective inhibitors of USP7.A force-activated trip switch triggers rapid dissociation of a colicin from its immunity protein.Human germline antibody gene segments encode polyspecific antibodies.Computational design of affinity and specificity at protein-protein interfacesAnalysis and modeling of the variable region of camelid single-domain antibodies.OptMAVEn--a new framework for the de novo design of antibody variable region models targeting specific antigen epitopes.Design of Protein Multi-specificity Using an Independent Sequence Search Reduces the Barrier to Low Energy Sequences.Computer-aided antibody design.Rosetta:MSF: a modular framework for multi-state computational protein design.Molecular mechanisms and design principles for promiscuous inhibitors to avoid drug resistance: lessons learned from HIV-1 protease inhibition.Computationally Designed Bispecific Antibodies using Negative State Repertoires.E9-Im9 colicin DNase-immunity protein biomolecular association in water: a multiple-copy and accelerated molecular dynamics simulation studySpecialized Dynamical Properties of Promiscuous Residues Revealed by Simulated Conformational Ensembles.Challenges in the computational design of proteinsComputer-aided design of functional protein interactions.
P2860
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P2860
description
2007 nî lūn-bûn
@nan
2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Design of multi-specificity in protein interfaces
@ast
Design of multi-specificity in protein interfaces
@en
type
label
Design of multi-specificity in protein interfaces
@ast
Design of multi-specificity in protein interfaces
@en
prefLabel
Design of multi-specificity in protein interfaces
@ast
Design of multi-specificity in protein interfaces
@en
P2860
P1476
Design of multi-specificity in protein interfaces
@en
P2093
Elisabeth L Humphris
P2860
P356
10.1371/JOURNAL.PCBI.0030164
P407
P577
2007-08-01T00:00:00Z