53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks
about
ALDH1A1 maintains ovarian cancer stem cell-like properties by altered regulation of cell cycle checkpoint and DNA repair network signalingUbiquitin-dependent recruitment of the Bloom syndrome helicase upon replication stress is required to suppress homologous recombinationFIGNL1-containing protein complex is required for efficient homologous recombination repairThe proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break responseThe splicing-factor related protein SFPQ/PSF interacts with RAD51D and is necessary for homology-directed repair and sister chromatid cohesionA DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signalingHuman RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaksThe histone demethylase LSD1/KDM1A promotes the DNA damage response53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancersFunctional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joiningProteomics of mouse BRCA1-deficient mammary tumors identifies DNA repair proteins with potential diagnostic and prognostic value in human breast cancerWriters, Readers, and Erasers of Histone Ubiquitylation in DNA Double-Strand Break RepairNew treatment option for ovarian cancer: PARP inhibitorsTrial watch - inhibiting PARP enzymes for anticancer therapyThe Knowns Unknowns: Exploring the Homologous Recombination Repair Pathway in Toxoplasma gondiiThe Landscape of Pancreatic Cancer Therapeutic Resistance MechanismsCellular Pathways in Response to Ionizing Radiation and Their Targetability for Tumor RadiosensitizationRole of Deubiquitinating Enzymes in DNA RepairA Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage ResponseFine-tuning the ubiquitin code at DNA double-strand breaks: deubiquitinating enzymes at workHomologous Recombination Deficiency: Exploiting the Fundamental Vulnerability of Ovarian CancerInhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer TherapyPARP inhibitors in the management of breast cancer: current data and future prospects53BP1: pro choice in DNA repairBRCA1, a 'complex' protein involved in the maintenance of genomic stabilityMetabolic modulation of chromatin: implications for DNA repair and genomic integrityDNA DSB repair pathway choice: an orchestrated handover mechanismDouble-strand break repair-adox: Restoration of suppressed double-strand break repair during mitosis induces genomic instabilityDNA double-strand break repair pathway choice and cancerThe role of PARP in DNA repair and its therapeutic exploitationPredictive models for customizing chemotherapy in advanced non-small cell lung cancer (NSCLC)Repair of strand breaks by homologous recombinationTargeting DNA damage response in cancer therapyCrosstalk between ubiquitin and other post-translational modifications on chromatin during double-strand break repairPARP Inhibitors for BRCA1/2 mutation-associated and BRCA-like malignanciesA phase II evaluation of the potent, highly selective PARP inhibitor veliparib in the treatment of persistent or recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer in patients who carry a germline BRCA1 or BRCA2 mutation - AnFemtosecond near-infrared laser microirradiation reveals a crucial role for PARP signaling on factor assemblies at DNA damage sites.COM-1 promotes homologous recombination during Caenorhabditis elegans meiosis by antagonizing Ku-mediated non-homologous end joiningHuman RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaksAcetylation limits 53BP1 association with damaged chromatin to promote homologous recombination
P2860
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P2860
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
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name
53BP1 inhibits homologous reco ...... ocking resection of DNA breaks
@ast
53BP1 inhibits homologous reco ...... ocking resection of DNA breaks
@en
type
label
53BP1 inhibits homologous reco ...... ocking resection of DNA breaks
@ast
53BP1 inhibits homologous reco ...... ocking resection of DNA breaks
@en
prefLabel
53BP1 inhibits homologous reco ...... ocking resection of DNA breaks
@ast
53BP1 inhibits homologous reco ...... ocking resection of DNA breaks
@en
P2093
P2860
P3181
P1433
P1476
53BP1 inhibits homologous reco ...... ocking resection of DNA breaks
@en
P2093
Amanda Gunn
André Nussenzweig
Anne Bothmer
Chu-Xia Deng
Elsa Callén
Federica Polato
Hua-Tang Chen
Jeremy M Stark
Nancy Wong
P2860
P304
P3181
P356
10.1016/J.CELL.2010.03.012
P407
P577
2010-04-01T00:00:00Z