The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease - Test2 - elhamkhani - TriplyDB

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

http://www.wikidata.org/entity/Q29547614

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Genome-scale screening of drug-target associations relevant to Ki using a chemogenomics approach Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease Deoxygedunin, a natural product with potent neurotrophic activity in mice A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK Identification of direct protein targets of small molecules Chapter 7: Pharmacogenomics Concise review: new paradigms for Down syndrome research using induced pluripotent stem cells: tackling complex human genetic disease Systems medicine: the future of medical genomics and healthcare Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma CancerResource: a comprehensive database of cancer-relevant proteins and compound interactions supported by experimental knowledge Genome-environment interactions that modulate aging: powerful targets for drug discovery Direct inhibition of the NOTCH transcription factor complex Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells RETRACTED: A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities Functional genomic analysis of amniotic fluid cell-free mRNA suggests that oxidative stress is significant in Down syndrome fetuses The implications of human metabolic network topology for disease comorbidity A crowdsourcing approach for reusing and meta-analyzing gene expression data Molecular signatures associated with ZIKV exposure in human cortical neural progenitors Computational approaches in target identification and drug discovery Systems psychopharmacology: A network approach to developing novel therapies Regulation of mTORC1 by growth factors, energy status, amino acids and mechanical stimuli at a glance Stepping into the omics era: Opportunities and challenges for biomaterials science and engineering Precision medicine for cancer with next-generation functional diagnostics Transcriptomic Approaches to Neural Repair An Omics Perspective on Molecular Biomarkers for Diagnosis, Prognosis, and Therapeutics of Cholangiocarcinoma Tumor-Derived Cell Lines as Molecular Models of Cancer Pharmacogenomics Regulation of zebrafish sleep and arousal states: current and prospective approaches Systems pharmacology: network analysis to identify multiscale mechanisms of drug action Mitochondrial targets for pharmacological intervention in human disease Targeting melanoma by small molecules: challenges ahead Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes Beyond modules and hubs: the potential of gene coexpression networks for investigating molecular mechanisms of complex brain disorders From integrative genomics to therapeutic targets Strategic applications of gene expression: from drug discovery/development to bedside A survey on the computational approaches to identify drug targets in the postgenomic era Targeted therapy in gastric cancer: personalizing cancer treatment based on patient genome Big data in chemical toxicity research: the use of high-throughput screening assays to identify potential toxicants Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review

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The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

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