Targeting MYC dependence in cancer by inhibiting BET bromodomains - Test2 - elhamkhani - TriplyDB

Targeting MYC dependence in cancer by inhibiting BET bromodomains

Targeting MYC dependence in cancer by inhibiting BET bromodomains

http://www.wikidata.org/entity/Q29617196

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Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability Drugging MYCN through an allosteric transition in Aurora kinase A Phospho switch triggers Brd4 chromatin binding and activator recruitment for gene-specific targeting Histone recognition and large-scale structural analysis of the human bromodomain family Small-molecule inhibition of BRDT for male contraception.Epimutational profile of hematologic malignancies as attractive target for new epigenetic therapies Bromodomain Inhibitor Review: Bromodomain and Extra-terminal Family Protein Inhibitors as a Potential New Therapy in Central Nervous System Tumors Strategically targeting MYC in cancer DNA Methylation and Chromatin Remodeling: The Blueprint of Cancer Epigenetics Targeted drugs in small-cell lung cancer Regulation of MYC gene expression by aberrant Wnt/β-catenin signaling in colorectal cancer MYC-driven aggressive B-cell lymphomas: biology, entity, differential diagnosis and clinical management Linking epithelial-to-mesenchymal-transition and epigenetic modifications Combating the epigenome: epigenetic drugs against non-Hodgkin's lymphoma Coordination of nutrient availability and utilization by MAX- and MLX-centered transcription networks KATs in cancer: functions and therapies Epigenetic regulators as promising therapeutic targets in acute myeloid leukemia The bromodomain: from epigenome reader to druggable target Cancer epigenetics drug discovery and development: the challenge of hitting the mark Proteomics in epigenetics: new perspectives for cancer research Protein lysine acetylation by p300/CBP Epigenetic plasticity: a central regulator of epithelial-to-mesenchymal transition in cancer Getting up to speed with transcription elongation by RNA polymerase II Small-molecule inhibitors of the Myc oncoprotein Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637)Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition Optimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain Ligands BET Inhibition Silences Expression of MYCN and BCL2 and Induces Cytotoxicity in Neuroblastoma Tumor Models Dual kinase-bromodomain inhibitors for rationally designed polypharmacology Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading BRD4-targeted therapy induces Myc-independent cytotoxicity in Gnaq/11-mutatant uveal melanoma cells.BET inhibitors in the treatment of hematologic malignancies: current insights and future prospects Therapeutic aspects of c-MYC signaling in inflammatory and cancerous colonic diseases The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous Proteins Acetylation Reader Proteins: Linking Acetylation Signaling to Genome Maintenance and Cancer Epigenetics in Cancer: A Hematological Perspective BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain

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P2860

Targeting MYC dependence in cancer by inhibiting BET bromodomains

http://www.wikidata.org/entity/Q29617196

description

2011 nî lūn-bûn

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2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

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2011年論文

@zh-tw

2011年论文

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name

Targeting MYC dependence in cancer by inhibiting BET bromodomains

@ast

Targeting MYC dependence in cancer by inhibiting BET bromodomains

@en

type

label

Targeting MYC dependence in cancer by inhibiting BET bromodomains

@ast

Targeting MYC dependence in cancer by inhibiting BET bromodomains

@en

prefLabel

Targeting MYC dependence in cancer by inhibiting BET bromodomains

@ast

Targeting MYC dependence in cancer by inhibiting BET bromodomains

@en

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PNAS.1108190108

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Targeting MYC dependence in cancer by inhibiting BET bromodomains

@en

P2093

Andrew R Conery

http://www.w3.org/2001/XMLSchema#string

Deanna A Mele

http://www.w3.org/2001/XMLSchema#string

Jennifer A Mertz

http://www.w3.org/2001/XMLSchema#string

Louise Bergeron

http://www.w3.org/2001/XMLSchema#string

Peter Sandy

http://www.w3.org/2001/XMLSchema#string

Robert J Sims

http://www.w3.org/2001/XMLSchema#string

Srividya Balasubramanian

http://www.w3.org/2001/XMLSchema#string

P2860

Selective inhibition of BET bromodomains

Brd4 recruits P-TEFb to chromosomes at late mitosis to promote G1 gene expression and cell cycle progression

The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls

NUT midline carcinoma

Suppression of inflammation by a synthetic histone mimic

Negative regulation of the mammalian UV response by Myc through association with Miz-1

The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

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16669-16674

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scholarly article

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1446949

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10.1073/PNAS.1108190108

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40

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108

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2011-09-26T00:00:00Z

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51676140

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21949397

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3189078

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