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Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive valueTwelve type 2 diabetes susceptibility loci identified through large-scale association analysisGenome-wide association analyses identify 18 new loci associated with serum urate concentrationsAnalysis of KLF transcription factor family gene variants in type 2 diabetesHypertension and vascular dynamics in men and women with metabolic syndromeA multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis. UDCA-PBC Study GroupNew genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes riskLarge-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetesA genome-wide association study identifies novel risk loci for type 2 diabetesCommon variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac deathVariation in FTO contributes to childhood obesity and severe adult obesityEIF4A2 is a positional candidate gene at the 3q27 locus linked to type 2 diabetes in French familiesGenome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populationsDysfunction of lipid sensor GPR120 leads to obesity in both mouse and humanDirectional dominance on stature and cognition in diverse human populationsGlucose-dependent regulation of NR2F2 promoter and influence of SNP-rs3743462 on whole body insulin sensitivityA genome-wide association search for type 2 diabetes genes in African AmericansTwo new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groupsGenome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumptionGenetic variation in GIPR influences the glucose and insulin responses to an oral glucose challengeGenome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibilityStratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.The genetic architecture of type 2 diabetesRare and low-frequency coding variants alter human adult heightGenome-wide analysis identifies 12 loci influencing human reproductive behavior.Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.Whole-exome sequencing and high throughput genotyping identified KCNJ11 as the thirteenth MODY gene.Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the epidemiologic data on the insulin resistance syndrome prospective study.The PPARG Pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years and combines with the effect of the APM1 G-11391A single nucleotide polymorphism: the Data From an Epidemiological Study on the Insulin ResiUse of HbA1c in predicting progression to diabetes in French men and women: data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR).Ferritin and transferrin are both predictive of the onset of hyperglycemia in men and women over 3 years: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study.TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study.Ferritin and transferrin are associated with metabolic syndrome abnormalities and their change over time in a general population: Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR).Consequences of change in waist circumference on cardiometabolic risk factors over 9 years: Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR).Gamma-glutamyltransferase activity and development of the metabolic syndrome (International Diabetes Federation Definition) in middle-aged men and women: Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR) cohort.Calcium consumption and insulin resistance syndrome parameters. Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR).Predicting diabetes: clinical, biological, and genetic approaches: data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR).Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distributionNovel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways
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P50
description
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հետազոտող
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name
Beverley Balkau
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Beverley Balkau
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Beverley Balkau
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Beverley Balkau
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Beverley Balkau
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Beverley Balkau
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Beverley Balkau
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Beverley Balkau
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Beverley Balkau
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Beverley Balkau
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Beverley Balkau
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Beverley Balkau
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Beverley Balkau
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Beverley Balkau
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Beverley Balkau
@sl