Microtubule affinity-regulating kinase 2 (MARK2) turns on phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) at Thr-313, a mutation site in Parkinson disease: effects on mitochondrial transport

Microtubule affinity-regulating kinase 2 (MARK2) turns on phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) at Thr-313, a mutation site in Parkinson disease: effects on mitochondrial transport

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http://www.wikidata.org/entity/Q30273872

Q30273872

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PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402 Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease Emerging modes of PINK1 signaling: another task for MARK2 An old molecule with a new role: microtubules in inflammasome regulation.Beyond the mitochondrion: cytosolic PINK1 remodels dendrites through protein kinase A Parkinson's Disease in Saudi Patients: A Genetic Study In Vitro Comparison of the Activity Requirements and Substrate Specificity of Human and Triboleum castaneum PINK1 Orthologues.Characterization of PINK1 (PTEN-induced putative kinase 1) mutations associated with Parkinson disease in mammalian cells and Drosophila Cytosolic PINK1 promotes the targeting of ubiquitinated proteins to the aggresome-autophagy pathway during proteasomal stress.Reversal of neurofibrillary tangles and tau-associated phenotype in the rTgTauEC model of early Alzheimer's disease.Back to the tubule: microtubule dynamics in Parkinson's disease.Analysis of the regulatory and catalytic domains of PTEN-induced kinase-1 (PINK1).Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences.Function and characteristics of PINK1 in mitochondria.Mitochondria dynamism: of shape, transport and cell migration.Impairment of mitochondria dynamics by human A53T α-synuclein and rescue by NAP (davunetide) in a cell model for Parkinson's disease.PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival.Identification of Ser465 as a novel PINK1 autophosphorylation site.Structure of PINK1 in complex with its substrate ubiquitin.Unbiased Proteomics of Early Lewy Body Formation Model Implicates Active Microtubule Affinity-Regulating Kinases (MARKs) in Synucleinopathies.MARK2 Rescues Nogo-66-Induced Inhibition of Neurite Outgrowth via Regulating Microtubule-Associated Proteins in Neurons In Vitro.Reduction of PINK1 or DJ-1 impair mitochondrial motility in neurites and alter ER-mitochondria contacts

P2860

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P2860

Microtubule affinity-regulating kinase 2 (MARK2) turns on phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) at Thr-313, a mutation site in Parkinson disease: effects on mitochondrial transport

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2012年の論文

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