Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.
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Unstable microtubule capture at kinetochores depleted of the centromere-associated protein CENP-F.ZW10 links mitotic checkpoint signaling to the structural kinetochore.Inhibition of TRIP1/S8/hSug1, a component of the human 19S proteasome, enhances mitotic apoptosis induced by spindle poisonsThe CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cellsThe human spindle assembly checkpoint protein Bub3 is required for the establishment of efficient kinetochore-microtubule attachments.Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signalingThe human Mis12 complex is required for kinetochore assembly and proper chromosome segregation.Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP.The role of aneuploidy in promoting and suppressing tumorsMicrotubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signalingBub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesisDido disruption leads to centrosome amplification and mitotic checkpoint defects compromising chromosome stabilityMad2 overexpression promotes aneuploidy and tumorigenesis in miceChromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomesStem cells, senescence, neosis and self-renewal in cancer.Small-molecule kinase inhibitors provide insight into Mps1 cell cycle functionSpindle assembly checkpoint regulates mitotic cell cycle progression during preimplantation embryo developmentThe accuracy of survival time prediction for patients with glioma is improved by measuring mitotic spindle checkpoint gene expressionThe causes and consequences of genetic heterogeneity in cancer evolutionA high throughput, whole cell screen for small molecule inhibitors of the mitotic spindle checkpoint identifies OM137, a novel Aurora kinase inhibitorMLN8054, a small-molecule inhibitor of Aurora A, causes spindle pole and chromosome congression defects leading to aneuploidy.Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice.High levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells.Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisonsChromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors.Inducible microRNA expression by an all-in-one episomal vector system.The progeroid gene BubR1 regulates axon myelination and motor function.Separating the spindle, checkpoint, and timer functions of BubR1Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma.Mutual dependence of Mob1 and the chromosomal passenger complex for localization during mitosis.The MPS1 family of protein kinases.Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacyWhole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity.Pellino 1 inactivates mitotic spindle checkpoint by targeting BubR1 for ubiquitinational degradation.Transcriptional control of BubR1 by p53 and suppression of centrosome amplification by BubR1BUB3 that dissociates from BUB1 activates caspase-independent mitotic death (CIMD).Generating chromosome instability through the simultaneous deletion of Mad2 and p53.A dominant interfering Bub1 mutant is insufficient to induce or alter thymic tumorigenesis in vivo, even in a sensitized genetic background.Mitotic chromosomal instability and cancer: mouse modelling of the human disease.Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma
P2860
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P2860
Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.
description
2004 nî lūn-bûn
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2004 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2004 թվականի մայիսին հրատարակված գիտական հոդված
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2004年の論文
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年學術文章
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name
Lethality to human cancer cell ...... tion of the mitotic checkpoint
@nl
Lethality to human cancer cell ...... ion of the mitotic checkpoint.
@ast
Lethality to human cancer cell ...... ion of the mitotic checkpoint.
@en
type
label
Lethality to human cancer cell ...... tion of the mitotic checkpoint
@nl
Lethality to human cancer cell ...... ion of the mitotic checkpoint.
@ast
Lethality to human cancer cell ...... ion of the mitotic checkpoint.
@en
prefLabel
Lethality to human cancer cell ...... tion of the mitotic checkpoint
@nl
Lethality to human cancer cell ...... ion of the mitotic checkpoint.
@ast
Lethality to human cancer cell ...... ion of the mitotic checkpoint.
@en
P2860
P3181
P356
P1476
Lethality to human cancer cell ...... tion of the mitotic checkpoint
@en
P2093
Daniel R Foltz
P2860
P304
P3181
P356
10.1073/PNAS.0401142101
P407
P577
2004-05-24T00:00:00Z