Spindly/CCDC99 is required for efficient chromosome congression and mitotic checkpoint regulation
about
The astrin-kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignmentCyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesisCep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1-Mad2.Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signalingDynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunitKinetochore-microtubule attachment is sufficient to satisfy the human spindle assembly checkpointKinetochores: orchestrating the chromosomal minuet.Human chromokinesins promote chromosome congression and spindle microtubule dynamics during mitosisA novel role of farnesylation in targeting a mitotic checkpoint protein, human Spindly, to kinetochoresDistinct domains in Bub1 localize RZZ and BubR1 to kinetochores to regulate the checkpoint.Conditional targeting of MAD1 to kinetochores is sufficient to reactivate the spindle assembly checkpoint in metaphase.Uncovering the molecular machinery of the human spindle--an integration of wet and dry systems biology.Kinetochore motors drive congression of peripheral polar chromosomes by overcoming random arm-ejection forces.Mutual regulation between the spindle checkpoint and APC/C.Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors.Microtubule binding by KNL-1 contributes to spindle checkpoint silencing at the kinetochore.Mitosis. Microtubule detyrosination guides chromosomes during mitosisRanGTP aids anaphase entry through Ubr5-mediated protein turnover.Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster.Quantitative phosphoproteomics reveals genistein as a modulator of cell cycle and DNA damage response pathways in triple-negative breast cancer cells.Spindle assembly checkpoint proteins are positioned close to core microtubule attachment sites at kinetochores.Phospho-regulation pathways during egg activation in Drosophila melanogaster.Proteomics Analysis with a Nano Random Forest Approach Reveals Novel Functional Interactions Regulated by SMC Complexes on Mitotic Chromosomes.Crosstalk between microtubule attachment complexes ensures accurate chromosome segregation.Mechanisms of Chromosome Congression during Mitosis.Monitoring the fidelity of mitotic chromosome segregation by the spindle assembly checkpoint.Spindle assembly checkpoint: the third decade.Connecting up and clearing out: how kinetochore attachment silences the spindle assembly checkpoint.Dynamic regulation of kinetochore-microtubule interaction during mitosis.Function and regulation of dynein in mitotic chromosome segregation.Chromosome misalignments induce spindle-positioning defects.Structure of the RZZ complex and molecular basis of its interaction with Spindly.Molecular mechanism of dynein recruitment to kinetochores by the Rod-Zw10-Zwilch complex and Spindly.A Molecular View of Kinetochore Assembly and Function.The translational landscape of the splicing factor SRSF1 and its role in mitosis.Statin-induced depletion of geranylgeranyl pyrophosphate inhibits cell proliferation by a novel pathway of Skp2 degradation.Release of Mps1 from kinetochores is crucial for timely anaphase onset.Lipids beyond membranes; farnesylation targets Spindly to kinetochoresMolecular Mechanisms of Spindle Assembly Checkpoint Activation and Silencing.PARP inhibition causes premature loss of cohesion in cancer cells.
P2860
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P2860
Spindly/CCDC99 is required for efficient chromosome congression and mitotic checkpoint regulation
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Spindly/CCDC99 is required for ...... mitotic checkpoint regulation
@ast
Spindly/CCDC99 is required for ...... mitotic checkpoint regulation
@en
type
label
Spindly/CCDC99 is required for ...... mitotic checkpoint regulation
@ast
Spindly/CCDC99 is required for ...... mitotic checkpoint regulation
@en
prefLabel
Spindly/CCDC99 is required for ...... mitotic checkpoint regulation
@ast
Spindly/CCDC99 is required for ...... mitotic checkpoint regulation
@en
P2093
P2860
P356
P1476
Spindly/CCDC99 is required for ...... mitotic checkpoint regulation
@en
P2093
Bénédicte Sohm
Cornelia Wandke
Günther Bonn
Michael Hess
Petra Mikolcevic
Stephan Geley
Thomas Ringer
Veronika Rauch
P2860
P304
P356
10.1091/MBC.E09-04-0356
P577
2010-04-28T00:00:00Z