Microtubule binding by KNL-1 contributes to spindle checkpoint silencing at the kinetochore. - Test2 - elhamkhani - TriplyDB

Microtubule binding by KNL-1 contributes to spindle checkpoint silencing at the kinetochore.

Microtubule binding by KNL-1 contributes to spindle checkpoint silencing at the kinetochore.

http://www.wikidata.org/entity/Q35770562

about

KNL1: bringing order to the kinetochore Nup132 modulates meiotic spindle attachment in fission yeast by regulating kinetochore assembly.Kinetochore components are required for central spindle assembly.Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1-Mad2.Structural basis for microtubule recognition by the human kinetochore Ska complex Cnn1 inhibits the interactions between the KMN complexes of the yeast kinetochore.A Cell Biological Perspective on Past, Present and Future Investigations of the Spindle Assembly Checkpoint The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores Connecting the microtubule attachment status of each kinetochore to cell cycle arrest through the spindle assembly checkpoint.Looping in on Ndc80 - how does a protein loop at the kinetochore control chromosome segregation?Alp7/TACC recruits kinesin-8-PP1 to the Ndc80 kinetochore protein for timely mitotic progression and chromosome movement.Tension-dependent removal of pericentromeric shugoshin is an indicator of sister chromosome biorientation.The kinetochore encodes a mechanical switch to disrupt spindle assembly checkpoint signalling.The outer kinetochore protein KNL-1 contains a defined oligomerization domain in nematodes.Kinetochore-localized BUB-1/BUB-3 complex promotes anaphase onset in C. elegans Targeted Knockdown of the Kinetochore Protein D40/Knl-1 Inhibits Human Cancer in a p53 Status-Independent Manner.The KMN protein network--chief conductors of the kinetochore orchestra How the SAC gets the axe: Integrating kinetochore microtubule attachments with spindle assembly checkpoint signaling.Making an effective switch at the kinetochore by phosphorylation and dephosphorylation.The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis.The composition, functions, and regulation of the budding yeast kinetochore KNL1 facilitates phosphorylation of outer kinetochore proteins by promoting Aurora B kinase activity.Arrayed BUB recruitment modules in the kinetochore scaffold KNL1 promote accurate chromosome segregation.A Bub1-Mad1 interaction targets the Mad1-Mad2 complex to unattached kinetochores to initiate the spindle checkpoint.Establishment of the vertebrate kinetochores.Regulatory mechanisms of kinetochore-microtubule interaction in mitosis.Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore.Functions of the centromere and kinetochore in chromosome segregation.Linked in: formation and regulation of microtubule attachments during chromosome segregation.Signalling dynamics in the spindle checkpoint response.The role of structural disorder in cell cycle regulation, related clinical proteomics, disease development and drug targeting.Evolutionary Lessons from Species with Unique Kinetochores.Regulation of mitotic progression by the spindle assembly checkpoint Kinetochore assembly and function through the cell cycle.Phosphoregulation of Spc105 by Mps1 and PP1 regulates Bub1 localization to kinetochores.Natural Loss of Mps1 Kinase in Nematodes Uncovers a Role for Polo-like Kinase 1 in Spindle Checkpoint Initiation.PP2A-B56 opposes Mps1 phosphorylation of Knl1 and thereby promotes spindle assembly checkpoint silencing Phosphodependent recruitment of Bub1 and Bub3 to Spc7/KNL1 by Mph1 kinase maintains the spindle checkpoint.Kinetochores accelerate or delay APC/C activation by directing Cdc20 to opposing fates.Knl1 shows another face.

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P2860

Microtubule binding by KNL-1 contributes to spindle checkpoint silencing at the kinetochore.

http://www.wikidata.org/entity/Q35770562

description

2012 nî lūn-bûn

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2012年の論文

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2012年论文

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name

Microtubule binding by KNL-1 c ...... silencing at the kinetochore.

@ast

Microtubule binding by KNL-1 c ...... silencing at the kinetochore.

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type

label

Microtubule binding by KNL-1 c ...... silencing at the kinetochore.

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Microtubule binding by KNL-1 c ...... silencing at the kinetochore.

@en

prefLabel

Microtubule binding by KNL-1 c ...... silencing at the kinetochore.

@ast

Microtubule binding by KNL-1 c ...... silencing at the kinetochore.

@en

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P1433

Journal of Cell Biology

P1476

Microtubule binding by KNL-1 c ...... silencing at the kinetochore.

@en

P2093

Arshad Desai

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Julien Espeut

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Lenno Krenning

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P2860

Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes

Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1

Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites

A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension

Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly

Docking motif-guided mapping of the interactome of protein phosphatase-1

The conserved KMN network constitutes the core microtubule-binding site of the kinetochore

Linking kinetochore-microtubule binding to the spindle checkpoint

Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation

Functional analysis of kinetochore assembly in Caenorhabditis elegans.

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469-482

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scholarly article

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10.1083/JCB.201111107

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4

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196

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Dhanya K Cheerambathur

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2012-02-13T00:00:00Z

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221830064

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22331849

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3284002

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