A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments.
about
Beyond directed evolution--semi-rational protein engineering and designExploring protein fitness landscapes by directed evolutionA family of thermostable fungal cellulases created by structure-guided recombinationSCHEMA recombination of a fungal cellulase uncovers a single mutation that contributes markedly to stabilityThe SWISS-MODEL Repository and associated resourcesOptimization of the bacterial cytochrome P450 BM3 system for the production of human drug metabolitesChimeragenesis of distantly-related proteins by noncontiguous recombinationKey Mutations Alter the Cytochrome P450 BM3 Conformational Landscape and Remove Inherent Substrate BiasStructure-Guided Directed Evolution of Highly Selective P450-Based Magnetic Resonance Imaging Sensors for Dopamine and SerotoninAddressing biological uncertainties in engineering gene circuitsAnswering evolutionary questions: A guide for mechanistic biologists.Deletional protein engineering based on stable fold.SCHEMA computational design of virus capsid chimeras: calibrating how genome packaging, protection, and transduction correlate with calculated structural disruption.Consensus protein design without phylogenetic biasSCHEMA-designed variants of human Arginase I and II reveal sequence elements important to stability and catalysis.Random field model reveals structure of the protein recombinational landscape.A diverse set of family 48 bacterial glycoside hydrolase cellulases created by structure-guided recombination.Expression-level optimization of a multi-enzyme pathway in the absence of a high-throughput assay.A panel of cytochrome P450 BM3 variants to produce drug metabolites and diversify lead compounds.Protein structural modularity and robustness are associated with evolvability.Comparison of CYP106A1 and CYP106A2 from Bacillus megaterium - identification of a novel 11-oxidase activity.Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsinsNavigating the protein fitness landscape with Gaussian processesConstructing de novo biosynthetic pathways for chemical synthesis inside living cells.P450(BM3) (CYP102A1): connecting the dots.Recent advances in rational approaches for enzyme engineering.Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently.Efficient screening of fungal cellobiohydrolase class I enzymes for thermostabilizing sequence blocks by SCHEMA structure-guided recombination.How conformational flexibility stabilizes the hyperthermophilic elongation factor G-domain.Metal-substituted protein MRI contrast agents engineered for enhanced relaxivity and ligand sensitivity.Recombination of protein fragments: a promising approach toward engineering proteins with novel nanomechanical properties.PROTS: a fragment based protein thermo-stability potentialA divide-and-conquer approach to determine the Pareto frontier for optimization of protein engineering experimentsPredicting protein thermostability changes from sequence upon multiple mutations.Learning epistatic interactions from sequence-activity data to predict enantioselectivity.Machine learning to design integral membrane channelrhodopsins for efficient eukaryotic expression and plasma membrane localization.Enzyme stabilization via computationally guided protein stapling.Simultaneous retention of thermostability and specific activity in chimeric human alkaline phosphatases.Combinatorial recombination of gene fragments to construct a library of chimerasApplication of fourier transform and proteochemometrics principles to protein engineering
P2860
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P2860
A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments.
description
2007 nî lūn-bûn
@nan
2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
A diverse family of thermostab ...... tion of stabilizing fragments.
@ast
A diverse family of thermostab ...... tion of stabilizing fragments.
@en
A diverse family of thermostab ...... tion of stabilizing fragments.
@nl
type
label
A diverse family of thermostab ...... tion of stabilizing fragments.
@ast
A diverse family of thermostab ...... tion of stabilizing fragments.
@en
A diverse family of thermostab ...... tion of stabilizing fragments.
@nl
prefLabel
A diverse family of thermostab ...... tion of stabilizing fragments.
@ast
A diverse family of thermostab ...... tion of stabilizing fragments.
@en
A diverse family of thermostab ...... tion of stabilizing fragments.
@nl
P50
P356
P1433
P1476
A diverse family of thermostab ...... tion of stabilizing fragments.
@en
P2093
Andrew M Sawayama
P2888
P304
P356
10.1038/NBT1333
P577
2007-08-26T00:00:00Z
P5875
P6179
1005767213