Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice.
about
DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosisThe role of oxidative stress in Parkinson's diseaseEvaluation of Models of Parkinson's DiseaseThe role of free radicals in the aging brain and Parkinson's Disease: convergence and parallelismIncreased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits.Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neuronsDJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidaseProgressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function.R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice.Analysis of targeted mutation in DJ-1 on cellular function in primary astrocytes.DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway.Brain mitochondria from DJ-1 knockout mice show increased respiration-dependent hydrogen peroxide consumption.DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human alpha-syn toxicity.A plant DJ-1 homolog is essential for Arabidopsis thaliana chloroplast development.DJ-1 can inhibit microtubule associated protein 1 B formed aggregatesLoss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathwayKeap1-Nrf2 activation in the presence and absence of DJ-1.Expression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment.MsrA knockout mouse exhibits abnormal behavior and brain dopamine levelsAnimal models of Parkinson's disease progressionIncreased DJ-1 expression under oxidative stress and in Alzheimer's disease brains.Analysis of inflammation-related nigral degeneration and locomotor function in DJ-1(-/-) mice.SOD2 in mitochondrial dysfunction and neurodegeneration.Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps.Oxidative stress in genetic mouse models of Parkinson's disease.Impaired neurotransmitter release in Alzheimer's and Parkinson's diseases.Neuroprotective potential of Quercetin in combination with piperine against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity.Choice of biological source material supersedes oxidative stress in its influence on DJ-1 in vivo interactions with Hsp90.Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice.DJ-1 Inhibits α-Synuclein Aggregation by Regulating Chaperone-Mediated Autophagy.Evidence of oxidative stress in young and aged DJ-1-deficient mice.
P2860
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P2860
Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice.
description
2007 nî lūn-bûn
@nan
2007 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Absence of dopaminergic neuron ...... e in aged DJ-1-deficient mice.
@ast
Absence of dopaminergic neuron ...... e in aged DJ-1-deficient mice.
@en
type
label
Absence of dopaminergic neuron ...... e in aged DJ-1-deficient mice.
@ast
Absence of dopaminergic neuron ...... e in aged DJ-1-deficient mice.
@en
prefLabel
Absence of dopaminergic neuron ...... e in aged DJ-1-deficient mice.
@ast
Absence of dopaminergic neuron ...... e in aged DJ-1-deficient mice.
@en
P2860
P356
P1476
Absence of dopaminergic neuron ...... e in aged DJ-1-deficient mice.
@en
P2093
Hiroo Yamaguchi
P2860
P2888
P356
10.1186/1750-1326-2-10
P577
2007-05-29T00:00:00Z
P5875
P6179
1050334940