A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1. - Test2 - elhamkhani - TriplyDB

A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1.

A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1.

http://www.wikidata.org/entity/Q30573927

about

PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402 Cytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagy Ubiquitin phosphorylation in Parkinson's disease: Implications for pathogenesis and treatment Pathologic and therapeutic implications for the cell biology of parkin Mitophagy and the mitochondrial unfolded protein response in neurodegeneration and bacterial infection Targeting Pink1-Parkin-mediated mitophagy for treating liver injury A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region Beyond mitophagy: cytosolic PINK1 as a messenger of mitochondrial health Chemical Proteomic Profiling of Human Methyltransferases Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity PINK1 triggers autocatalytic activation of Parkin to specify cell fate decisions GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors Midbrain dopamine neurons in Parkinson's disease exhibit a dysregulated miRNA and target-gene network The role of mitochondrially derived ATP in synaptic vesicle recycling Understanding the susceptibility of dopamine neurons to mitochondrial stressors in Parkinson's disease.Structural Basis for the Non-catalytic Functions of Protein Kinases.In Vitro Comparison of the Activity Requirements and Substrate Specificity of Human and Triboleum castaneum PINK1 Orthologues.The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease The Mitochondrial Basis of Aging.Analog sensitive chemical inhibition of the DEAD-box protein DDX3 The Autophagy-Lysosomal Pathway in Neurodegeneration: A TFEB Perspective Unravelling mitochondrial pathways to Parkinson's disease.Evidence to support mitochondrial neuroprotection, in severe traumatic brain injury.The Effects of Variants in the Parkin, PINK1, and DJ-1 Genes along with Evidence for their Pathogenicity.Revisiting protein kinase-substrate interactions: Toward therapeutic development.The mitochondrial kinase PINK1: functions beyond mitophagy.PINK1 in the limelight: multiple functions of an eclectic protein in human health and disease.The pharmacological regulation of cellular mitophagy.Mitophagy in neurodegeneration and aging.Ubiquitin and Parkinson's disease through the looking glass of genetics.Trumping neurodegeneration: Targeting common pathways regulated by autosomal recessive Parkinson's disease genes.Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease.Kinetin Riboside and Its ProTides Activate the Parkinson's Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization Mitochondria in the context of Parkinson's disease.A chemical genetic approach to probe the function of PINK1 in regulating mitochondrial dynamics.Mitophagy as a Protective Mechanism against Myocardial Stress.Natural plant hormones cytokinins increase stress resistance and longevity of Caenorhabditis elegans.PINK1-Based Screen Shines Light on Autophagy Enhancers for Parkinson's Disease.The Anthelmintic Drug Niclosamide and its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1.

P2860

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P2860

A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1.

http://www.wikidata.org/entity/Q30573927

description

2013 nî lūn-bûn

@nan

2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

A neo-substrate that amplifies ...... -disease-related kinase PINK1.

@ast

A neo-substrate that amplifies ...... -disease-related kinase PINK1.

@en

type

label

A neo-substrate that amplifies ...... -disease-related kinase PINK1.

@ast

A neo-substrate that amplifies ...... -disease-related kinase PINK1.

@en

prefLabel

A neo-substrate that amplifies ...... -disease-related kinase PINK1.

@ast

A neo-substrate that amplifies ...... -disease-related kinase PINK1.

@en

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P2860

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P356

J.CELL.2013.07.030

P1433

P1476

A neo-substrate that amplifies ...... s-disease-related kinase PINK1

@en

P2093

Al L Burlingame

http://www.w3.org/2001/XMLSchema#string

Amandine Berthet

http://www.w3.org/2001/XMLSchema#string

Ken Nakamura

http://www.w3.org/2001/XMLSchema#string

Kevan M Shokat

http://www.w3.org/2001/XMLSchema#string

Martin L Sos

http://www.w3.org/2001/XMLSchema#string

P2860

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease

PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility

The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations

The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking

Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

P304

737-747

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P31

scholarly article

P356

10.1016/J.CELL.2013.07.030

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P407

P433

4

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P478

154

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P50

Nicholas T. Hertz

P577

2013-08-01T00:00:00Z

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P5875

255973630

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P698

23953109

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P921

Parkinson's disease

P932

3950538

http://www.w3.org/2001/XMLSchema#string