EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia. - Test2 - elhamkhani - TriplyDB

EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia.

EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia.

http://www.wikidata.org/entity/Q30574640

about

Targeting New Candidate Genes by Small Molecules Approaching Neurodegenerative Diseases Ataxia-telangiectasia: future prospects Astrocyte Differentiation of Human Pluripotent Stem Cells: New Tools for Neurological Disorder Research Ataxia telangiectasia: a review Epigenetics and therapeutic targets mediating neuroprotection miR-200b inhibits CD133+ glioma cells by targeting the AKT pathway Polycomb and trithorax opposition in development and disease.Regulation and Role of EZH2 in Cancer Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency.Epigenetic mechanisms underlying the pathogenesis of neurogenetic diseases FOXA1 repression is associated with loss of BRCA1 and increased promoter methylation and chromatin silencing in breast cancer.Functional Crosstalk Between Lysine Methyltransferases on Histone Substrates: The Case of G9A/GLP and Polycomb Repressive Complex 2 Genetic and epigenetic profiling of CLL disease progression reveals limited somatic evolution and suggests a relationship to memory-cell development MiR-101 reverses the hypomethylation of the LMO3 promoter in glioma cells.Spontaneous ATM Gene Reversion in A-T iPSC to Produce an Isogenic Cell Line.Neurons in Vulnerable Regions of the Alzheimer's Disease Brain Display Reduced ATM Signaling.Polycomb Ezh2 controls the fate of GABAergic neurons in the embryonic cerebellum.The impact of glutamine supplementation on the symptoms of ataxia-telangiectasia: a preclinical assessment.Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration.The role of epigenomics in the neurodegeneration of ataxia-telangiectasia.Associating transcription factors and conserved RNA structures with gene regulation in the human brain.Chromatin Changes Associated with Neuronal Maintenance and Their Pharmacological Application.Computational prediction of methylation types of covalently modified lysine and arginine residues in proteins.Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.Re-imagining Alzheimer's disease - the diminishing importance of amyloid and a glimpse of what lies ahead.Engrailed Homeoprotein Protects Mesencephalic Dopaminergic Neurons from Oxidative Stress Individual Cytokines Modulate the Neurological Symptoms of ATM Deficiency in a Region Specific Manner(1,2,3)The Histone H3K27 Demethylase UTX Regulates Synaptic Plasticity and Cognitive Behaviors in Mice.Praja1 E3 ubiquitin ligase promotes skeletal myogenesis through degradation of EZH2 upon p38α activation.Functional and molecular defects of hiPSC-derived neurons from patients with ATM deficiency Trimethylation of H3K27 during human cerebellar development in relation to medulloblastoma.Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington's disease.Ataxia telangiectasia syndrome: moonlighting ATM.Polycomb Repressive Complex 2: Emerging Roles in the Central Nervous System.Telomerase reverse transcriptase (TERT) - enhancer of zeste homolog 2 (EZH2) network regulates lipid metabolism and DNA damage responses in glioblastoma.Ezh2 does not mediate retinal ganglion cell homeostasis or their susceptibility to injury.Loopholes in the DNA contract kill neurons.EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer.DNA damage in the oligodendrocyte lineage and its role in brain aging.EZH2 orchestrates apicobasal polarity and neuroepithelial cell renewal.

P2860

Q26771812-1BA9FA16-F081-4402-B105-23DCDFBD7F60 Q26863728-B92906F6-6D51-49B4-A9AE-B4E3C53A587E Q28068029-CDACF44F-87D4-4495-AD1B-CD8FB9A70A57 Q28079581-5D1A8584-21AE-4B11-86C8-882B18D862FB Q28080633-B38F3ECE-A061-41CD-8F1B-956CD1D3C8D4 Q33750928-7574594B-6420-4CF6-9255-6E9913096B60 Q33920032-E3F76F12-536F-4949-AE08-648CA81561B5 Q34043370-4DAAC0EC-3A82-40EE-825A-10CB27663207 Q34499746-B3809D5D-999C-421C-9F0A-B9211DD19A5D Q35340073-C4D57B34-DDB1-495B-AF04-0630119CE297 Q35602325-9DE7256E-D6D3-4F62-99A2-E85271FED1C2 Q35609473-B28BEC1D-9A7E-4F93-865F-E366708A397D Q35669051-19C70A71-CB56-417E-802A-91A1DF54EC53 Q35781470-1E9A653D-98DE-445C-903B-96AC54808503 Q36379473-F895C605-8893-4870-B6DA-BD2460ADDE3B Q36627277-9734D8CA-2462-4EDE-9B03-64821AB80647 Q37036183-B6CC3BF2-EA87-4457-893F-DDBBAAA095B4 Q37189170-E40F9044-9D51-4C8D-991B-604AA5699704 Q37383788-488A123F-3340-4ABB-AAEC-E67DB1E1D1B6 Q38459830-803850F4-F407-463F-8483-C58FB07347C9 Q38673142-735F4A5F-54DE-4E95-91C0-A225E55EC77F Q38676090-64393D7E-4B27-45D1-999F-AE7A57475310 Q38860670-D9C226E4-5DCF-43CA-8F01-A175806A8B0B Q38925490-E9AA5355-E99F-4ABA-AD51-09834A872968 Q39332179-71EFCC41-0A81-4853-B5F3-4DF76933FF0E Q40494780-CA2ED45B-BF95-4A0E-8F02-9CEF9EF66E61 Q41193099-5B95B255-03AD-4036-A1E8-A6FA8F41A4B4 Q41840374-B3AC6D4A-ABA7-4B84-91D7-271A8ABBB87F Q42282686-3DEA393A-1B42-431C-B607-572A4E5B6210 Q42771888-3F7253C9-7946-4C1B-BA26-C5EBFE3BE56E Q47132607-3974A62D-35E7-4B17-A34C-77C22A9C5AB5 Q47252056-3794A3A1-1849-4367-AB93-88255F316936 Q47649609-DB4C922D-AC32-45AB-A41B-14C385E394DE Q47893021-14804322-2B1C-4D27-9C9E-F7E7F277AD94 Q47916801-C92DBB55-2554-45D3-9595-D3807A10705E Q48097604-B72DAAEC-430C-4190-9F3B-24429CB8A2F2 Q48164362-FC101A8F-B81B-4A16-B8C6-6981BE98E988 Q48325256-4DF9FE6E-0B33-4AD2-A298-26883DA65B13 Q48709568-75DE3A10-1E14-4212-97F3-56604108998F Q49751213-04552F14-C500-49A1-BFFB-A685BE5DBE9E

P2860

EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia.

http://www.wikidata.org/entity/Q30574640

description

2013 nî lūn-bûn

@nan

2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia.

@ast

EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia.

@en

type

label

EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia.

@ast

EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia.

@en

prefLabel

EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia.

@ast

EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia.

@en

P1433

Q30574640-56B7F210-2982-4AE8-803A-F57EA1F5DF63

P1476

Q30574640-1576BE2D-62D2-4FF9-B6FC-3D486AE5A4FA

P2093

Q30574640-0C5C461D-A5FF-4F06-BE7D-188C941ED8A8

Q30574640-D7056D20-A73D-4845-97F9-3728B3ECE138

Q30574640-FE865329-CE20-42C4-9B1C-2CB3B5AA7607

P2860

Q30574640-005515AD-6633-4F1C-99C9-DD8048774DCE

Q30574640-073376A3-90C0-4A0D-A8E3-E53819F61994

Q30574640-0768F0DE-4D98-4B7A-9F95-657A70CC409F

Q30574640-180367BB-676C-4727-BFEA-D81CBD52B6FD

Q30574640-19839F21-F8CF-4AEF-88D3-8673A4C77971

Q30574640-2150F8D2-A7C4-48EF-ADFB-226162C774FF

Q30574640-24A905D5-A99A-4F1C-AAA0-BC27F1FD0212

Q30574640-2EE2B42E-61E2-447C-BEEC-717873F7643B

Q30574640-3A3CDD3E-AF3E-4219-A687-775BD03EBEA8

Q30574640-3A81B661-51EB-4ECE-9F76-E4F133C0B546

P2888

Q30574640-2D9E16F7-641C-4D53-B8D4-5E2F17D1224E

P304

Q30574640-4D52129F-B6A6-4CC1-BBB4-66DB60BA73F9

P31

Q30574640-5559A374-C786-47B6-B4B2-ABB44991D0A3

P356

Q30574640-443F5FD6-AD60-48A9-A099-AC48E6C8646F

P407

Q30574640-D667236E-AE6F-48D5-9A3C-B7C95BAA6E0D

P433

Q30574640-957E6F47-D01C-4AEF-A6F6-C69DD5EEE878

P478

Q30574640-ACED8BCD-28E2-4DAC-A865-FDF14FA6D3C4

P50

Q30574640-1CEC3D00-697C-4EE9-941A-B8B31DA3FDC5

Q30574640-9CB552E7-5DF5-41FC-A215-26BF9EE4A173

Q30574640-B36DA0ED-DF8A-46BC-AE6D-230FD038AB4F

Q30574640-DFE7F32A-1D59-4540-9AD4-6DF27F8926B8

P577

Q30574640-1F0F6BCA-E786-4CF3-BCD3-95446FF969F0

P5875

Q30574640-94D0A13A-9C7A-4FCE-90D7-D5A8108024DF

P6179

Q30574640-9EE3AA36-46B0-4763-B8FA-5EA7D9441DBA

P698

Q30574640-B6CEEF75-DA43-4083-A18A-DB29BBB7C5AD

P932

Q30574640-28EAAEB1-AEED-472D-978B-27A93EC9B2BF

P356

P1433

Nature Neuroscience

P1476

EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia.

@en

P2093

Alexander W Kusnecov

http://www.w3.org/2001/XMLSchema#string

Elyse M Mallimo

http://www.w3.org/2001/XMLSchema#string

Mavis R Swerdel

http://www.w3.org/2001/XMLSchema#string

P2860

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA

Cytoplasmic ATM in neurons modulates synaptic function

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cells

SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex

Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3

The Polycomb group protein EZH2 impairs DNA repair in breast epithelial cells

P2888

P304

1745-1753

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NN.3564

http://www.w3.org/2001/XMLSchema#string

P407

P433

12

http://www.w3.org/2001/XMLSchema#string

P478

16

http://www.w3.org/2001/XMLSchema#string

P50

P577

2013-10-27T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

258103462

http://www.w3.org/2001/XMLSchema#string

P6179

1024366499

http://www.w3.org/2001/XMLSchema#string

P698

24162653

http://www.w3.org/2001/XMLSchema#string

P932

3965909

http://www.w3.org/2001/XMLSchema#string