Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors.
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Rational Design of Inhibitors and Activity-Based Probes Targeting Clostridium difficile Virulence Factor TcdBPeptide Length and Leaving-Group Sterics Influence Potency of Peptide Phosphonate Protease InhibitorsA Common Single Nucleotide Polymorphism in Endoplasmic Reticulum Aminopeptidase 2 Induces a Specificity Switch That Leads to Altered Antigen ProcessingThe X-ray Crystal Structure of Human Aminopeptidase N Reveals a Novel Dimer and the Basis for Peptide ProcessingDiscovery of α,β- and α,γ-diamino acid scaffolds for the inhibition of M1 family aminopeptidasesA Naturally Variable Residue in the S1 Subsite of M1 Family Aminopeptidases Modulates Catalytic Properties and Promotes Functional SpecializationThe Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach.Aminopeptidase N1 (EtAPN1), an M1 metalloprotease of the apicomplexan parasite Eimeria tenella, participates in parasite development.Enzyme-triggered gelation: targeting proteases with internal cleavage sitesFingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum.Gingipain aminopeptidase activities in Porphyromonas gingivalis.An integrated approach to the ligand binding specificity of Neisseria meningitidis M1 alanine aminopeptidase by fluorogenic substrate profiling, inhibitory studies and molecular modeling.Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases.Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling.A remarkable activity of human leukotriene A4 hydrolase (LTA4H) toward unnatural amino acidsSynthesis of fluorescent (benzyloxycarbonylamino)(aryl)methylphosphonates.Repositioning the substrate activity screening (SAS) approach as a fragment-based method for identification of weak binders.Molecular dynamics simulations of the Cx26 hemichannel: evaluation of structural models with Brownian dynamics.Structural basis for the inhibition of M1 family aminopeptidases by the natural product actinonin: Crystal structure in complex with E. coli aminopeptidase N.Identification of multiple structurally distinct, nonpeptidic small molecule inhibitors of protein arginine deiminase 3 using a substrate-based fragment methodDesign and Synthesis of Activity-Based Probes and Inhibitors for Bleomycin Hydrolase.Engagement of the S1, S1' and S2' subsites drives efficient catalysis of peptide bond hydrolysis by the M1-family aminopeptidase from Plasmodium falciparum.The DegraBase: a database of proteolysis in healthy and apoptotic human cellsA structural insight into the P1S1 binding mode of diaminoethylphosphonic and phosphinic acids, selective inhibitors of alanine aminopeptidases.The Staphylococcus aureus leucine aminopeptidase is localized to the bacterial cytosol and demonstrates a broad substrate range that extends beyond leucine3,4-Dihydroxyphenylalanine Peptides as Nonperturbative Quantum Dot Sensors of Aminopeptidase.Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides.Proteolytic Activity Matrix Analysis (PrAMA) for simultaneous determination of multiple protease activitiesSubstrate Activity Screening (SAS) and Related Approaches in Medicinal Chemistry.Emerging challenges in the design of selective substrates, inhibitors and activity-based probes for indistinguishable proteases.The first ratiometric fluorescent probes for aminopeptidase N cell imaging.Biochemical characterization of aminopeptidase N2 from Toxoplasma gondii.Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues.Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity.Presence and regulation of insulin-regulated aminopeptidase in mouse macrophages.A multi-step peptidolytic cascade for amino acid recovery in chloroplasts.The first ratiometric fluorescent probe for aminopeptidase N
P2860
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P2860
Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors.
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Aminopeptidase fingerprints, a ...... trates and optimal inhibitors.
@ast
Aminopeptidase fingerprints, a ...... trates and optimal inhibitors.
@en
type
label
Aminopeptidase fingerprints, a ...... trates and optimal inhibitors.
@ast
Aminopeptidase fingerprints, a ...... trates and optimal inhibitors.
@en
prefLabel
Aminopeptidase fingerprints, a ...... trates and optimal inhibitors.
@ast
Aminopeptidase fingerprints, a ...... trates and optimal inhibitors.
@en
P2093
P2860
P356
P1476
Aminopeptidase fingerprints, a ...... trates and optimal inhibitors.
@en
P2093
Guy S Salvesen
Jonathan A Ellman
Marcin Drag
P2860
P304
P356
10.1074/JBC.M109.060418
P407
P577
2009-11-30T00:00:00Z