Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin.
about
Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substratesCatalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VIIHuman recombinant endopeptidase PHEX has a strict S1' specificity for acidic residues and cleaves peptides derived from fibroblast growth factor-23 and matrix extracellular phosphoglycoproteinProtease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavageMicrofluidics and coagulation biologyIdentification and Biochemical Characterization of Small-Molecule Inhibitors of West Nile Virus Serine Protease by a High-Throughput ScreenSpecificity profiling of seven human tissue kallikreins reveals individual subsite preferencesRat mast cell protease 4 is a beta-chymase with unusually stringent substrate recognition profileDefinition of the extended substrate specificity determinants for beta-tryptases I and II.Advances in the use of synthetic combinatorial chemistry: mixture-based libraries.Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate librariesAminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors.Printing chemical libraries on microarrays for fluid phase nanoliter reactions.A protein kinase associated with apoptosis and tumor suppression: structure, activity, and discovery of peptide substrates.Altered substrate specificity of drug-resistant human immunodeficiency virus type 1 protease.Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancersThe caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites.Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities.Modulation of infectivity in phage display as a tool to determine the substrate specificity of proteases.Dual colour, microarray-based, analysis of 10,000 protease substrates.Combinatorial strategies for targeting protein families: application to the proteases.Defining the extended substrate specificity of kallikrein 1-related peptidases.Fibroblast activation protein peptide substrates identified from human collagen I derived gelatin cleavage sites.Using specificity to strategically target proteases.Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function.A rapid method for generation of selective Sox-based chemosensors of Ser/Thr kinases using combinatorial peptide libraries.A sequence and structure based method to predict putative substrates, functions and regulatory networks of endo proteases.Inhibition of a viral enzyme by a small-molecule dimer disruptor.Discovery of novel proteasome inhibitors using a high-content cell-based screening systemProteomic profiling of proteases: tools for granzyme degradomics.Expanding the dipeptidyl peptidase 4-regulated peptidome via an optimized peptidomics platform.Inflammatory stimuli regulate caspase substrate profiles.Engineering of substrate selectivity for tissue factor.factor VIIa complex signaling through protease-activated receptor 2.Substrate specifity profiling of the Aspergillus fumigatus proteolytic secretome reveals consensus motifs with predominance of Ile/Leu and Phe/TyrRobust substrate profiling method reveals striking differences in specificities of serum and lung fluid proteases.Modifications to the hemagglutinin cleavage site control the virulence of a neurotropic H1N1 influenza virusThe extended cleavage specificity of human thrombin.Emerging principles in protease-based drug discovery.Nanoparticles that sense thrombin activity as synthetic urinary biomarkers of thrombosis.Proteolytic fingerprinting of complex biological samples using combinatorial libraries of fluorogenic probes.
P2860
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P2860
Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin.
description
2000 nî lūn-bûn
@nan
2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Synthesis of positional-scanni ...... icity of plasmin and thrombin.
@ast
Synthesis of positional-scanni ...... icity of plasmin and thrombin.
@en
type
label
Synthesis of positional-scanni ...... icity of plasmin and thrombin.
@ast
Synthesis of positional-scanni ...... icity of plasmin and thrombin.
@en
prefLabel
Synthesis of positional-scanni ...... icity of plasmin and thrombin.
@ast
Synthesis of positional-scanni ...... icity of plasmin and thrombin.
@en
P2093
P2860
P356
P1433
P1476
Synthesis of positional-scanni ...... icity of plasmin and thrombin.
@en
P2093
P2860
P2888
P304
P356
10.1038/72642
P577
2000-02-01T00:00:00Z