about
Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4FFoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesisAATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosisSurvivin is required for a sustained spindle checkpoint arrest in response to lack of tensionActivation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRADCheckpoint recovery in cells: how a molecular understanding can help in the fight against cancerMps1 phosphorylates Borealin to control Aurora B activity and chromosome alignmentPolo-like kinase-1 is activated by aurora A to promote checkpoint recoveryThe beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cellsThe decision to enter mitosis: feedback and redundancy in the mitotic entry networkA complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinasesFOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbodyControl of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factorsUncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeresSustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-β-dependent cancer metastasisRegulation of localization and activity of the microtubule depolymerase MCAKChromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomesIntravital FRET imaging of tumor cell viability and mitosis during chemotherapyBicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entryHypersensitivity to DNA damage in antephase as a safeguard for genome stability.Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensingExpression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell linesThe forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2Polo-like kinases: a team in control of the divisionCell death by mitotic catastrophe: a molecular definitionPolo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recoveryFoxM1 is degraded at mitotic exit in a Cdh1-dependent mannerFoxM1 is required for execution of the mitotic programme and chromosome stabilityThe APC/C recruits cyclin B1-Cdk1-Cks in prometaphase before D box recognition to control mitotic exitForkhead transcription factor FOXO3a protects quiescent cells from oxidative stressCLIP-170 facilitates the formation of kinetochore-microtubule attachments.Mps1 promotes rapid centromere accumulation of Aurora B.Nuclear envelope-associated dynein drives prophase centrosome separation and enables Eg5-independent bipolar spindle formation.Distinct phosphatases antagonize the p53 response in different phases of the cell cycleUncoupling anaphase-promoting complex/cyclosome activity from spindle assembly checkpoint control by deregulating polo-like kinase 1.Mutations in LRRC50 predispose zebrafish and humans to seminomas.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
René H Medema
@nl
René H Medema
@sl
René H. Medema
@en
René H. Medema
@es
René Medema
@fr
type
label
René H Medema
@nl
René H Medema
@sl
René H. Medema
@en
René H. Medema
@es
René Medema
@fr
prefLabel
René H Medema
@nl
René H Medema
@sl
René H. Medema
@en
René H. Medema
@es
René Medema
@fr
P106
P1153
7006449662
P21
P31
P496
0000-0002-6754-0381
P5463
Medema_Rene