Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes - Test2 - elhamkhani - TriplyDB

Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes

Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes

http://www.wikidata.org/entity/Q27301063

about

Dishevelled, a Wnt signalling component, is involved in mitotic progression in cooperation with Plk1.Loss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint ARHGEF17 is an essential spindle assembly checkpoint factor that targets Mps1 to kinetochores Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function A TPR domain–containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora B Structure-Based Design of Orally Bioavailable 1 H -Pyrrolo[3,2- c ]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint)Chemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosis Quantitative mass spectrometry analysis reveals similar substrate consensus motif for human Mps1 kinase and Plk1 Structural and functional characterization of the protein kinase Mps1 in Arabidopsis thaliana Mitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical Utility Kinetochore-microtubule attachment is sufficient to satisfy the human spindle assembly checkpoint A Centromere-Signaling Network Underlies the Coordination among Mitotic Events Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex.High levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells.Drosophila Polo regulates the spindle assembly checkpoint through Mps1-dependent BubR1 phosphorylation The MPS1 family of protein kinases.Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine Dynamic autophosphorylation of mps1 kinase is required for faithful mitotic progression Cellular abundance of Mps1 and the role of its carboxyl terminal tail in substrate recruitment.Feedback control in sensing chromosome biorientation by the Aurora B kinase.Two LXXLL motifs in the N terminus of Mps1 are required for Mps1 nuclear import during G(2)/M transition and sustained spindle checkpoint responses.The Spindle Assembly Checkpoint Safeguards Genomic Integrity of Skeletal Muscle Satellite Cells.Characterization of spindle checkpoint kinase Mps1 reveals domain with functional and structural similarities to tetratricopeptide repeat motifs of Bub1 and BubR1 checkpoint kinases.Spindle checkpoint-independent inhibition of mitotic chromosome segregation by Drosophila Mps1.Regulation of kinetochore recruitment of two essential mitotic spindle checkpoint proteins by Mps1 phosphorylation Effects of the selective MPS1 inhibitor MPS1-IN-3 on glioblastoma sensitivity to antimitotic drugs.Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells.Mitosis as an anti-cancer drug target.Playing polo during mitosis: PLK1 takes the lead.Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis.Targeting the mitotic checkpoint to kill tumor cells.Plk1 bound to Bub1 contributes to spindle assembly checkpoint activity during mitosis.Protein Phosphatase 1 inactivates Mps1 to ensure efficient Spindle Assembly Checkpoint silencing.Release of Mps1 from kinetochores is crucial for timely anaphase onset.Mps1 Regulates Kinetochore-Microtubule Attachment Stability via the Ska Complex to Ensure Error-Free Chromosome Segregation.Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint.High frequency of TTK mutations in microsatellite-unstable colorectal cancer and evaluation of their effect on spindle assembly checkpoint.Leader of the SAC: molecular mechanisms of Mps1/TTK regulation in mitosis

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Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes

http://www.wikidata.org/entity/Q27301063

description

2008 nî lūn-bûn

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2008 թուականին հրատարակուած գիտական յօդուած

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2008 թվականին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Chromosomal instability by ine ...... kpoint and lagging chromosomes

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Chromosomal instability by ine ...... kpoint and lagging chromosomes

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Chromosomal instability by ine ...... kpoint and lagging chromosomes

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type

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Chromosomal instability by ine ...... kpoint and lagging chromosomes

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Chromosomal instability by ine ...... kpoint and lagging chromosomes

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Chromosomal instability by ine ...... kpoint and lagging chromosomes

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prefLabel

Chromosomal instability by ine ...... kpoint and lagging chromosomes

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Chromosomal instability by ine ...... kpoint and lagging chromosomes

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Chromosomal instability by ine ...... kpoint and lagging chromosomes

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JOURNAL.PONE.0002415

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Chromosomal instability by ine ...... kpoint and lagging chromosomes

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Arjan B Brenkman

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Geert J P L Kops

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Ian McLeod

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John R Yates

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Nannette Jelluma

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P2860

ZW10 links mitotic checkpoint signaling to the structural kinetochore.

Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment

Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss

Mutations of mitotic checkpoint genes in human cancers

Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication

Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.

Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis

Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

Crystal structure of a cAMP-dependent protein kinase mutant at 1.26A: new insights into the catalytic mechanism

The spindle-assembly checkpoint in space and time

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e2415

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3514036

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10.1371/JOURNAL.PONE.0002415

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6

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3

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René H. Medema

Don W Cleveland

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2008-01-01T00:00:00Z

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5310987

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18545697

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2408436

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