The inositol polyphosphate 5-phosphatases and the apurinic/apyrimidinic base excision repair endonucleases share a common mechanism for catalysis.
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CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase.Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles ...The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actinTotal sequence decomposition distinguishes functional modules, "molegos" in apurinic/apyrimidinic endonucleasesInositol polyphosphate 5-phosphatases; new players in the regulation of cilia and ciliopathiesCrystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificitySaccharomyces cerevisiae Ngl3p is an active 3'-5' exonuclease with a specificity towards poly-A RNA reminiscent of cellular deadenylases.The yeast inositol polyphosphate 5-phosphatases inp52p and inp53p translocate to actin patches following hyperosmotic stress: mechanism for regulating phosphatidylinositol 4,5-bisphosphate at plasma membrane invaginations.The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminalsMammalian inositol polyphosphate 5-phosphatase II can compensate for the absence of all three yeast Sac1-like-domain-containing 5-phosphatasesThe inositol polyphosphate 5-phosphatase, PIPP, Is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation.A mutation in synaptojanin 2 causes progressive hearing loss in the ENU-mutagenised mouse strain Mozart.Taking U out, with two nucleases?Phosphoinositide phosphatases in cell biology and disease.Perforin: structure, function, and role in human immunopathology.The structure of phosphoinositide phosphatases: Insights into substrate specificity and catalysis.Pleiotropic functions of EAPII/TTRAP/TDP2: cancer development, chemoresistance and beyondExoMeg1: a new exonuclease from metagenomic library.Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases.RNA damage in biological conflicts and the diversity of responding RNA repair systemsArf6 and the 5'phosphatase of Synaptojanin 1 regulate autophagy in cone photoreceptorsHuman apurinic/apyrimidinic endonuclease 1.The structural basis for deadenylation by the CCR4-NOT complex.Regulation of NGF-driven neurite outgrowth by Ins(1,4,5)P3 kinase is specifically associated with the two isoenzymes Itpka and Itpkb in a model of PC12 cells.Structural basis for interdomain communication in SHIP2 providing high phosphatase activity.The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals.
P2860
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P2860
The inositol polyphosphate 5-phosphatases and the apurinic/apyrimidinic base excision repair endonucleases share a common mechanism for catalysis.
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2000 nî lūn-bûn
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name
The inositol polyphosphate 5-p ...... ommon mechanism for catalysis.
@ast
The inositol polyphosphate 5-p ...... ommon mechanism for catalysis.
@en
type
label
The inositol polyphosphate 5-p ...... ommon mechanism for catalysis.
@ast
The inositol polyphosphate 5-p ...... ommon mechanism for catalysis.
@en
prefLabel
The inositol polyphosphate 5-p ...... ommon mechanism for catalysis.
@ast
The inositol polyphosphate 5-p ...... ommon mechanism for catalysis.
@en
P2093
P2860
P356
P1476
The inositol polyphosphate 5-p ...... ommon mechanism for catalysis.
@en
P2093
C A Mitchell
H Nandurkar
J C Whisstock
S P Bottomley
P2860
P304
37055-37061
P356
10.1074/JBC.M006244200
P407
P577
2000-11-01T00:00:00Z