Allosteric activation of the protein kinase PDK1 with low molecular weight compounds
about
Small-Molecule Allosteric Modulators of the Protein Kinase PDK1 from Structure-Based DockingMechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylationInsights into protein kinase regulation and inhibition by large scale structural comparisonExploiting protein flexibility to predict the location of allosteric sitesComputational modeling of allosteric communication reveals organizing principles of mutation-induced signaling in ABL and EGFR kinases.Discovery of PDK1 kinase inhibitors with a novel mechanism of action by ultrahigh throughput screeningElastic network model of allosteric regulation in protein kinase PDK1Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway.Small-molecule inhibitors of protein-protein interactions: progressing toward the reality.Small-molecule procaspase activators identified using fluorescence polarization.A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1.Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.Fluorescence resonance energy transfer in quantum dot-protein kinase assembliesImpact of mutations on the allosteric conformational equilibrium.Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)Protein kinase inhibitors: contributions from structure to clinical compounds.Occupational hazards: allosteric regulation of protein kinases through the nucleotide-binding pocket.Cell-based apoptosis assays in oncology drug discovery.Targeting the unactivated conformations of protein kinases for small molecule drug discovery.Novel approaches for targeting kinases: allosteric inhibition, allosteric activation and pseudokinases.Regulation of the interaction between protein kinase C-related protein kinase 2 (PRK2) and its upstream kinase, 3-phosphoinositide-dependent protein kinase 1 (PDK1).Discovery of a Potent Allosteric Kinase Modulator by Combining Computational and Synthetic Methods.Regulation of protein kinase C-related protein kinase 2 (PRK2) by an intermolecular PRK2-PRK2 interaction mediated by Its N-terminal domain.Hydrophobic motif phosphorylation coordinates activity and polar localization of the Neurospora crassa nuclear Dbf2-related kinase COT1.Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology.
P2860
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P2860
Allosteric activation of the protein kinase PDK1 with low molecular weight compounds
description
2006 nî lūn-bûn
@nan
2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Allosteric activation of the protein kinase PDK1 with low molecular weight compounds
@ast
Allosteric activation of the protein kinase PDK1 with low molecular weight compounds
@en
Allosteric activation of the protein kinase PDK1 with low molecular weight compounds
@en-gb
Allosteric activation of the protein kinase PDK1 with low molecular weight compounds
@nl
type
label
Allosteric activation of the protein kinase PDK1 with low molecular weight compounds
@ast
Allosteric activation of the protein kinase PDK1 with low molecular weight compounds
@en
Allosteric activation of the protein kinase PDK1 with low molecular weight compounds
@en-gb
Allosteric activation of the protein kinase PDK1 with low molecular weight compounds
@nl
prefLabel
Allosteric activation of the protein kinase PDK1 with low molecular weight compounds
@ast
Allosteric activation of the protein kinase PDK1 with low molecular weight compounds
@en
Allosteric activation of the protein kinase PDK1 with low molecular weight compounds
@en-gb
Allosteric activation of the protein kinase PDK1 with low molecular weight compounds
@nl
P2093
P2860
P50
P356
P1433
P1476
Allosteric activation of the protein kinase PDK1 with low molecular weight compounds
@en
P2093
Iris Adrian
Jochen Imig
Laura A Lopez-Garcia
Matthias Engel
Rolf W Hartmann
P2860
P304
P356
10.1038/SJ.EMBOJ.7601416
P407
P50
P577
2006-11-29T00:00:00Z