Searching for new antimalarial therapeutics amongst known drugs.
about
A fluorescence-based thermal shift assay identifies inhibitors of mitogen activated protein kinase kinase 4Thioridazine: resurrection as an antimicrobial agent?Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparumDrug repurposing and human parasitic protozoan diseasesDrug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screeningVisualisation and quantitative analysis of the rodent malaria liver stage by real time imagingAgrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas diseaseSuppression of AKT anti-apoptotic signaling by a novel drug candidate results in growth arrest and apoptosis of hepatocellular carcinoma cellsA high throughput screen for RGS proteins using steady state monitoring of free phosphate formationA new in vivo screening paradigm to accelerate antimalarial drug discoveryAntiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug RepositioningDiscovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural ProductsChemical genetics of Plasmodium falciparumHigh-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinationsNovel paradigms for drug discovery: computational multitarget screeningBis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro.Inhibitors of tubulin assembly identified through screening a compound library.High-content live cell imaging with RNA probes: advancements in high-throughput antimalarial drug discovery.Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assayImage-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease.Repositioning: the fast track to new anti-malarial medicines?Finding promiscuous old drugs for new uses.High content live cell imaging for the discovery of new antimalarial marine natural productsA high throughput screen identifies Nefopam as targeting cell proliferation in β-catenin driven neoplastic and reactive fibroproliferative disorders.Target assessment for antiparasitic drug discovery.A class of tricyclic compounds blocking malaria parasite oocyst development and transmission.Malaria biology and disease pathogenesis: insights for new treatments.Screening and identification of compounds with antiviral activity against hepatitis B virus using a safe compound library and novel real-time immune-absorbance PCR-based high throughput system.Substrate selection influences molecular recognition in a screen for lymphoid tyrosine phosphatase inhibitorsChemical genomics for studying parasite gene function and interaction.Target validation: linking target and chemical properties to desired product profileAntiparasitic chemotherapy: from genomes to mechanisms.Discovery of potent, novel, non-toxic anti-malarial compounds via quantum modelling, virtual screening and in vitro experimental validationOptimization of propafenone analogues as antimalarial leadsLead optimization of antimalarial propafenone analogues.Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.Chemogenomic profiling of Plasmodium falciparum as a tool to aid antimalarial drug discovery.Drug discovery and development for neglected parasitic diseases.Celastrol inhibits Plasmodium falciparum enoyl-acyl carrier protein reductase.In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen
P2860
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P2860
Searching for new antimalarial therapeutics amongst known drugs.
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
name
Searching for new antimalarial therapeutics amongst known drugs.
@ast
Searching for new antimalarial therapeutics amongst known drugs.
@en
type
label
Searching for new antimalarial therapeutics amongst known drugs.
@ast
Searching for new antimalarial therapeutics amongst known drugs.
@en
prefLabel
Searching for new antimalarial therapeutics amongst known drugs.
@ast
Searching for new antimalarial therapeutics amongst known drugs.
@en
P2093
P2860
P1476
Searching for new antimalarial therapeutics amongst known drugs.
@en
P2093
Ally P Liou
Anang A Shelat
Jennifer L Weisman
Joseph L DeRisi
R Kiplin Guy
P2860
P304
P356
10.1111/J.1747-0285.2006.00391.X
P50
P577
2006-06-01T00:00:00Z