Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction. - Test2 - elhamkhani - TriplyDB

Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction.

Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction.

http://www.wikidata.org/entity/Q33331396

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SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection New insights into an X-traordinary viral protein SAMHD1-Dependent and -Independent Functions of HIV-2/SIV Vpx Protein The HIV1 protein Vpr acts to enhance constitutive DCAF1-dependent UNG2 turnover Identification and characterization of naturally occurring splice variants of SAMHD1 The human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infection HIV-1 replication through hHR23A-mediated interaction of Vpr with 26S proteasome How SAMHD1 changes our view of viral restriction SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates HIV-1 envelope-receptor interactions required for macrophage infection and implications for current HIV-1 cure strategies HIV restriction in quiescent CD4⁺ T cells Molecular mechanisms of HIV immune evasion of the innate immune response in myeloid cells Formation of mobile chromatin-associated nuclear foci containing HIV-1 Vpr and VPRBP is critical for the induction of G2 cell cycle arrest The DDB1-DCAF1-Vpr-UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destruction Restriction of HIV-1 replication in monocytes is abolished by Vpx of SIVsmmPBj SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.Interferon-alpha mediates restriction of human immunodeficiency virus type-1 replication in primary human macrophages at an early stage of replication.Interaction of Vpx and apolipoprotein B mRNA-editing catalytic polypeptide 3 family member A (APOBEC3A) correlates with efficient lentivirus infection of monocytes Host hindrance to HIV-1 replication in monocytes and macrophages.HIV-1 Vpr and G2 cell cycle arrest.The functions of the HIV1 protein Vpr and its action through the DCAF1.DDB1.Cullin4 ubiquitin ligase.Nuclear import of SAMHD1 is mediated by a classical karyopherin α/β1 dependent pathway and confers sensitivity to VpxMAC induced ubiquitination and proteasomal degradation.SIV Nef proteins recruit the AP-2 complex to antagonize Tetherin and facilitate virion release.APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells.Characterization of the alpha interferon-induced postentry block to HIV-1 infection in primary human macrophages and T cells.The inside out of lentiviral vectors Interleukin-27 is a potent inhibitor of cis HIV-1 replication in monocyte-derived dendritic cells via a type I interferon-independent pathway High-titre retroviral vector system for efficient gene delivery into human and mouse cells of haematopoietic and lymphocytic lineages.Identification of critical regions in human SAMHD1 required for nuclear localization and Vpx-mediated degradation The macrophage: the intersection between HIV infection and atherosclerosis.HIV-1 accessory protein Vpr: relevance in the pathogenesis of HIV and potential for therapeutic intervention Understanding the molecular manipulation of DCAF1 by the lentiviral accessory proteins Vpr and Vpx.Human immunodeficiency virus type 1 modified to package Simian immunodeficiency virus Vpx efficiently infects macrophages and dendritic cells.Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon.SAMHD1 restricts HIV-1 replication and regulates interferon production in mouse myeloid cells.Role of myeloid cells in HIV-1-host interplay.Lentiviral Gag assembly analyzed through the functional characterization of chimeric simian immunodeficiency viruses expressing different domains of the feline immunodeficiency virus capsid protein.SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation.Antiretroviral restriction factors.

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Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction.

http://www.wikidata.org/entity/Q33331396

description

2008 nî lūn-bûn

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2008 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2008 թվականի մայիսին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction.

@ast

Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction.

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Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction.

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type

label

Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction.

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Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction.

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Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction.

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prefLabel

Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction.

@ast

Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction.

@en

Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction.

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Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction.

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Mario Stevenson

http://www.w3.org/2001/XMLSchema#string

Mark Sharkey

http://www.w3.org/2001/XMLSchema#string

Natalia Sharova

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Rajnish Kaushik

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Ruzena Stranska

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Xiaonan Zhu

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Yuanfei Wu

http://www.w3.org/2001/XMLSchema#string

P2860

HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase

An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein.

Role and mechanism of action of the APOBEC3 family of antiretroviral resistance factors

Proteasome inhibitors uncouple rhesus TRIM5alpha restriction of HIV-1 reverse transcription and infection

The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells

Human immunodeficiency virus vpr product is a virion-associated regulatory protein

DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest

Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle

Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3

Human immunodeficiency virus type 1 Vpr protein binds to the uracil DNA glycosylase DNA repair enzyme

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2008-05-02T00:00:00Z

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2323106

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