DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest
about
The HIV1 protein Vpr acts to enhance constitutive DCAF1-dependent UNG2 turnoverThe human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infectionInvolvement of Lgl and Mahjong/VprBP in cell competitionVpr-binding protein antagonizes p53-mediated transcription via direct interaction with H3 tailFormation of mobile chromatin-associated nuclear foci containing HIV-1 Vpr and VPRBP is critical for the induction of G2 cell cycle arrestHow SLX4 cuts through the mystery of HIV-1 Vpr-mediated cell cycle arrest.The DDB1-DCAF1-Vpr-UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destructionCullin4A and cullin4B are interchangeable for HIV Vpr and Vpx action through the CRL4 ubiquitin ligase complexPrimate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction.Characterization of the molecular determinants of primary HIV-1 Vpr proteins: impact of the Q65R and R77Q substitutions on Vpr functions.HIV-1 Vpr inhibits cytokinesis in human proximal tubule cellsInteractions with DCAF1 and DDB1 in the CRL4 E3 ubiquitin ligase are required for Vpr-mediated G2 arrest.Vpr-host interactions during HIV-1 viral life cycle.HIV-1 Vpr and G2 cell cycle arrest.The functions of the HIV1 protein Vpr and its action through the DCAF1.DDB1.Cullin4 ubiquitin ligase.Protein kinase A phosphorylation activates Vpr-induced cell cycle arrest during human immunodeficiency virus type 1 infection.Exposed hydrophobic residues in human immunodeficiency virus type 1 Vpr helix-1 are important for cell cycle arrest and cell deathAPOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells.HIV-1 Vpr up-regulates expression of ligands for the activating NKG2D receptor and promotes NK cell-mediated killing.HIV-1 Vpr loads uracil DNA glycosylase-2 onto DCAF1, a substrate recognition subunit of a cullin 4A-ring E3 ubiquitin ligase for proteasome-dependent degradation.HIV-1 Vpr triggers mitochondrial destruction by impairing Mfn2-mediated ER-mitochondria interaction.Thriving under stress: selective translation of HIV-1 structural protein mRNA during Vpr-mediated impairment of eIF4E translation activity.De novo DNA methyltransferase DNMT3b interacts with NEDD8-modified proteins.Cullins and cancer.The Cullin-RING E3 ubiquitin ligase CRL4-DCAF1 complex dimerizes via a short helical region in DCAF1.Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development.HIV-1 accessory protein Vpr: relevance in the pathogenesis of HIV and potential for therapeutic interventionHIV-1 Vpr induces the degradation of ZIP and sZIP, adaptors of the NuRD chromatin remodeling complex, by hijacking DCAF1/VprBP.Gene expression profiles of HIV-1-infected glia and brain: toward better understanding of the role of astrocytes in HIV-1-associated neurocognitive disorders.Human immunodeficiency virus type 1 Vif causes dysfunction of Cdk1 and CyclinB1: implications for cell cycle arrest.Understanding the molecular manipulation of DCAF1 by the lentiviral accessory proteins Vpr and Vpx.Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon.Defining the interactions and role of DCAF1/VPRBP in the DDB1-cullin4A E3 ubiquitin ligase complex engaged by HIV-1 Vpr to induce a G2 cell cycle arrest.Proteomic profiling of the human cytomegalovirus UL35 gene products reveals a role for UL35 in the DNA repair responsePathogenic Role of the CRL4 Ubiquitin Ligase in Human DiseaseCRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10.Localization of HIV-1 Vpr to the nuclear envelope: impact on Vpr functions and virus replication in macrophagesDCAF1 controls T-cell function via p53-dependent and -independent mechanismsHIV-1 Vpr protein inhibits telomerase activity via the EDD-DDB1-VPRBP E3 ligase complexHIV-1 Vpr degrades the HLTF DNA translocase in T cells and macrophages.
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DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest
description
2007 nî lūn-bûn
@nan
2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
name
DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest
@ast
DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest
@en
DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest
@nl
type
label
DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest
@ast
DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest
@en
DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest
@nl
prefLabel
DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest
@ast
DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest
@en
DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest
@nl
P2093
P2860
P3181
P356
P1433
P1476
DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest
@en
P2093
Elana Ehrlich
Xiao-Fang Yu
P2860
P304
P3181
P356
10.1128/JVI.01380-07
P407
P577
2007-10-01T00:00:00Z