Improved tricyclic inhibitors of trypanothione reductase by screening and chemical synthesis.
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Mini review on tricyclic compounds as an inhibitor of trypanothione reductaseComparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruziBinding to large enzyme pockets: small-molecule inhibitors of trypanothione reductaseAntiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug RepositioningInvestigation of trypanothione reductase as a drug target in Trypanosoma brucei.Synthesis and evaluation of indatraline-based inhibitors for trypanothione reductaseSynthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase.Formation of DPM ethers using O-diphenylmethyl trichloroacetimidate under thermal conditions.Trypanocidal drugs: mechanisms, resistance and new targets.State of the art in African trypanosome drug discovery.Drug discovery and human African trypanosomiasis: a disease less neglected?Molecular recognition in chemical and biological systems.Screening the Medicines for Malaria Venture Pathogen Box across Multiple Pathogens Reclassifies Starting Points for Open-Source Drug Discovery.Chemotherapy of leishmaniasis: present challenges.Identification of potential trypanothione reductase inhibitors among commercially available [Formula: see text]-carboline derivatives using chemical space, lead-like and drug-like filters, pharmacophore models and molecular docking.Developing imidazole analogues as potential inhibitor for Leishmania donovani trypanothione reductase: virtual screening, molecular docking, dynamics and ADMET approach.Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase of Trypanosoma brucei.Synthesis, inhibition potency, binding mode, and antiprotozoal activities of fluorescent inhibitors of trypanothione reductase based on mepacrine-conjugated diaryl sulfide scaffolds.Probing the dimerization interface of Leishmania infantum trypanothione reductase with site-directed mutagenesis and short peptides.Febrifugine analogues as Leishmania donovani trypanothione reductase inhibitors: binding energy analysis assisted by molecular docking, ADMET and molecular dynamics simulation.Comparison of hydrocarbon-and lactam-bridged cyclic peptides as dimerization inhibitors of Leishmania infantum trypanothione reductase
P2860
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P2860
Improved tricyclic inhibitors of trypanothione reductase by screening and chemical synthesis.
description
2009 nî lūn-bûn
@nan
2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Improved tricyclic inhibitors ...... eening and chemical synthesis.
@ast
Improved tricyclic inhibitors ...... eening and chemical synthesis.
@en
type
label
Improved tricyclic inhibitors ...... eening and chemical synthesis.
@ast
Improved tricyclic inhibitors ...... eening and chemical synthesis.
@en
prefLabel
Improved tricyclic inhibitors ...... eening and chemical synthesis.
@ast
Improved tricyclic inhibitors ...... eening and chemical synthesis.
@en
P2093
P2860
P356
P1433
P1476
Improved tricyclic inhibitors ...... eening and chemical synthesis.
@en
P2093
Deuan C Jones
Isabelle R E Nett
John L Richardson
Mohamed H Abdille
P2860
P304
P356
10.1002/CMDC.200900097
P577
2009-08-01T00:00:00Z