Hepatobiliary disposition of troglitazone and metabolites in rat and human sandwich-cultured hepatocytes: use of Monte Carlo simulations to assess the impact of changes in biliary excretion on troglitazone sulfate accumulation.
about
Evaluation of Adverse Drug Properties with Cryopreserved Human Hepatocytes and the Integrated Discrete Multiple Organ Co-culture (IdMOC(TM)) SystemReduced physiologically-based pharmacokinetic model of repaglinide: impact of OATP1B1 and CYP2C8 genotype and source of in vitro data on the prediction of drug-drug interaction risk.Hepatocellular exposure of troglitazone metabolites in rat sandwich-cultured hepatocytes lacking Bcrp and Mrp2: interplay between formation and excretion.Sulindac and its metabolites inhibit multiple transport proteins in rat and human hepatocytes.Sandwich-cultured hepatocytes: utility for in vitro exploration of hepatobiliary drug disposition and drug-induced hepatotoxicity.Mechanisms underlying differences in systemic exposure of structurally similar active metabolites: comparison of two preclinical hepatic models.Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity.Species differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: implications for drug-induced liver injuryCombination lopinavir and ritonavir alter exogenous and endogenous bile acid disposition in sandwich-cultured rat hepatocytes.Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury.A perspective on efflux transport proteins in the liverHepatic basolateral efflux contributes significantly to rosuvastatin disposition I: characterization of basolateral versus biliary clearance using a novel protocol in sandwich-cultured hepatocytesIntracellular drug concentrations and transporters: measurement, modeling, and implications for the liver.Idiosyncratic Drug-Induced Liver Injury (IDILI): Potential Mechanisms and Predictive Assays.An experimental approach to evaluate the impact of impaired transport function on hepatobiliary drug disposition using Mrp2-deficient TR- rat sandwich-cultured hepatocytes in combination with Bcrp knockdown.Genetic variations of bile salt transporters as predisposing factors for drug-induced cholestasis, intrahepatic cholestasis of pregnancy and therapeutic response of viral hepatitis.In vitro methods to support transporter evaluation in drug discovery and development.Biomarkers and human hepatocytes.Prediction of Altered Bile Acid Disposition Due to Inhibition of Multiple Transporters: An Integrated Approach Using Sandwich-Cultured Hepatocytes, Mechanistic Modeling, and Simulation.Organic Solute Transporter OSTα/ß is Over-Expressed in Nonalcoholic Steatohepatitis and Modulated by Drugs Associated with Liver Injury.ABCC3 Polymorphisms and mRNA Expression Influence the Concentration of a Carboxylic Acid Metabolite in Patients on Clopidogrel and Aspirin Therapy.Farnesoid X Receptor Agonists Obeticholic Acid and Chenodeoxycholic Acid Increase Bile Acid Efflux in Sandwich-Cultured Human Hepatocytes: Functional Evidence and Mechanisms.Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach.
P2860
Q26801904-3F9A7A87-B1A6-443B-AFBB-72F05F3C1228Q30776360-F12CD423-EE24-4C30-BEDA-467642D53D70Q33742713-7040FB09-D79D-4755-80DB-0BB8CD4EBC35Q34035243-1BBC8401-2707-447D-90D3-96E64D62F7A5Q34330504-F84CCE73-B1CD-4E33-9685-6E0C6FC08DC9Q34868070-06B032F4-5C21-4499-854B-CC72AA0F1C42Q34990717-7C032A85-C66A-4970-92ED-8EB1F3906408Q35531814-8EF56C1E-2F0C-4314-98EE-968047D7DB45Q36497674-D4EAFC04-0EE3-400B-84BD-EFECEF1162C0Q36972804-8D745B43-EB05-43F7-B509-56E6218BD6B4Q37050337-6F4B0EF4-EB30-45B4-9BB4-8E90AE13128EQ37331801-A83B93A3-970D-4F2E-895D-335B6D1EAAE9Q37504548-FABF4986-59C3-4203-9F81-7EED0C8396B0Q37590883-4F17C8E5-CC11-40F9-96FA-8C54C4A49B70Q37714185-567AF766-8FBE-48CA-832D-83FA279711CBQ37841614-79311387-FB40-4EEE-904C-25D8F7FF8593Q38099194-77352B56-A609-435A-9BCC-DDF8BB555C94Q38187449-6B18632D-CABF-492D-9B5F-7ED5FF3F3919Q39730975-2A6C5E55-8CE6-4147-8302-A586DFB77255Q50116444-DB9D71CE-6200-4D0F-829B-00EFDDDE4A12Q51059883-EB7F8E0A-D96F-4CB2-8A7F-2147890781B9Q52682525-BE3E7049-99CE-4C2D-8B01-2641C5E7B821Q53188214-C91B809A-31E8-4CCF-839B-77BFB91CC0D8
P2860
Hepatobiliary disposition of troglitazone and metabolites in rat and human sandwich-cultured hepatocytes: use of Monte Carlo simulations to assess the impact of changes in biliary excretion on troglitazone sulfate accumulation.
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Hepatobiliary disposition of t ...... litazone sulfate accumulation.
@ast
Hepatobiliary disposition of t ...... litazone sulfate accumulation.
@en
Hepatobiliary disposition of t ...... litazone sulfate accumulation.
@nl
type
label
Hepatobiliary disposition of t ...... litazone sulfate accumulation.
@ast
Hepatobiliary disposition of t ...... litazone sulfate accumulation.
@en
Hepatobiliary disposition of t ...... litazone sulfate accumulation.
@nl
prefLabel
Hepatobiliary disposition of t ...... litazone sulfate accumulation.
@ast
Hepatobiliary disposition of t ...... litazone sulfate accumulation.
@en
Hepatobiliary disposition of t ...... litazone sulfate accumulation.
@nl
P2093
P2860
P356
P1476
Hepatobiliary disposition of t ...... glitazone sulfate accumulation
@en
P2093
Changwon Lim
Gary M Pollock
Jin Kyung Lee
Tracy L Marion
P2860
P356
10.1124/JPET.109.156653
P407
P50
P577
2009-10-02T00:00:00Z