about
Targeting the Mitotic Catastrophe Signaling Pathway in CancerApplication of a new dual localization-affinity purification tag reveals novel aspects of protein kinase biology in Aspergillus nidulansStructural basis of reversine selectivity in inhibiting Mps1 more potently than aurora B kinaseCentrosome - a promising anti-cancer targetStructural and functional characterization of the protein kinase Mps1 in Arabidopsis thalianaUV-C irradiation delays mitotic progression by recruiting Mps1 to kinetochoresCharacterization of novel MPS1 inhibitors with preclinical anticancer activityCharacterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacyThe kinetochoreMps1 phosphorylation of condensin II controls chromosome condensation at the onset of mitosis.Phosphorylation at threonine 288 by cell cycle checkpoint kinase 2 (CHK2) controls human monopolar spindle 1 (Mps1) kinetochore localization.Dynamic autophosphorylation of mps1 kinase is required for faithful mitotic progressionThe kinetochore encodes a mechanical switch to disrupt spindle assembly checkpoint signalling.Mining novel effector proteins from the esophageal gland cells of Meloidogyne incognita.A putative N-terminal nuclear export sequence is sufficient for Mps1 nuclear exclusion during interphaseThe Mps1 kinase modulates the recruitment and activity of Cnn1(CENP-T) at Saccharomyces cerevisiae kinetochoresTargeting MPS1 Enhances Radiosensitization of Human Glioblastoma by Modulating DNA Repair ProteinsKey role of dual specificity kinase TTK in proliferation and survival of pancreatic cancer cells.The Spindle Assembly Checkpoint Safeguards Genomic Integrity of Skeletal Muscle Satellite Cells.Mps1 (Monopolar Spindle 1) Protein Inhibition Affects Cellular Growth and Pro-Embryogenic Masses Morphology in Embryogenic Cultures of Araucaria angustifolia (Araucariaceae).Dynamic localization of Mps1 kinase to kinetochores is essential for accurate spindle microtubule attachmentGenetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability.TTK activates Akt and promotes proliferation and migration of hepatocellular carcinoma cells.Mps1 and Ipl1/Aurora B act sequentially to correctly orient chromosomes on the meiotic spindle of budding yeast.Whole-genome duplication increases tumor cell sensitivity to MPS1 inhibition.Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors.Mps1 kinase regulates tumor cell viability via its novel role in mitochondriaBubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancerAnalyses of Compact Trichinella Kinomes Reveal a MOS-Like Protein Kinase with a Unique N-Terminal Domain.Utility of the dual-specificity protein kinase TTK as a therapeutic target for intrahepatic spread of liver cancerIdentification of RSK and TTK as Modulators of Blood Vessel Morphogenesis Using an Embryonic Stem Cell-Based Vascular Differentiation AssayPhosphorylation of microtubule-binding protein Hec1 by mitotic kinase Aurora B specifies spindle checkpoint kinase Mps1 signaling at the kinetochore.Modulation of miR-21 signaling by MPS1 in human glioblastomaOn the molecular mechanisms of mitotic kinase activation.Chromosome segregation in budding yeast: sister chromatid cohesion and related mechanisms.Signalling dynamics in the spindle checkpoint response.Inhibition of the spindle assembly checkpoint kinase Mps-1 as a novel therapeutic strategy in malignant mesothelioma.Downregulation of tyrosine threonine kinase inhibits tumor growth via G2/M arrest in human endometrioid endometrial adenocarcinoma.APC/C-Cdc20 mediates deprotection of centromeric cohesin at meiosis II in yeast.Molecular basis underlying resistance to Mps1/TTK inhibitors.
P2860
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P2860
description
2012 nî lūn-bûn
@nan
2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
The MPS1 family of protein kinases.
@ast
The MPS1 family of protein kinases.
@en
type
label
The MPS1 family of protein kinases.
@ast
The MPS1 family of protein kinases.
@en
prefLabel
The MPS1 family of protein kinases.
@ast
The MPS1 family of protein kinases.
@en
P2860
P1476
The MPS1 family of protein kinases.
@en
P2093
Mark Winey
Xuedong Liu
P2860
P304
P356
10.1146/ANNUREV-BIOCHEM-061611-090435
P577
2012-04-05T00:00:00Z