The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalization
about
It all comes together at the ends: telomerase structure, function, and biogenesisTelomerase Regulation from Beginning to the EndThe TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasisA mutation in the catalytic subunit of yeast telomerase alters primer-template alignment while promoting processivity and protein-DNA binding.InTERTpreting telomerase structure and functionPrognostic role of telomerase activity in gastric adenocarcinoma: A meta-analysisTelomerase immortalization of principal cells from mouse collecting ductA yeast chemical genetic screen identifies inhibitors of human telomerase.Direct involvement of the TEN domain at the active site of human telomeraseTelomere repeat binding proteins are functional components of Arabidopsis telomeres and interact with telomerase.Human telomerase model shows the role of the TEN domain in advancing the double helix for the next polymerization step.Dyskeratosis congenita as a disorder of telomere maintenance.Telomerase regulatory subunit Est3 in two Candida species physically interacts with the TEN domain of TERT and telomeric DNA.Native gel electrophoresis of human telomerase distinguishes active complexes with or without dyskerin.Single-molecule imaging of telomerase reverse transcriptase in human telomerase holoenzyme and minimal RNP complexes.PTEN Inhibits Cell Proliferation, Promotes Cell Apoptosis, and Induces Cell Cycle Arrest via Downregulating the PI3K/AKT/hTERT Pathway in Lung Adenocarcinoma A549 Cells.Medical genetics and epigenetics of telomerase.Structure-function relationship and biogenesis regulation of the human telomerase holoenzyme.An intact putative mouse telomerase essential N-terminal domain is necessary for proper telomere maintenance.Long telomeres bypass the requirement for telomere maintenance in human tumorigenesis.Human telomerase domain interactions capture DNA for TEN domain-dependent processive elongation.Augmented telomerase activity and reduced telomere length in parthenium-induced contact dermatitis.Human telomerase specialization for repeat synthesis by unique handling of primer-template duplex.The emerging role of telomerase reverse transcriptase in mitochondrial DNA metabolism.Structure and function of the N-terminal domain of the yeast telomerase reverse transcriptase.Tandem affinity purification of AtTERT reveals putative interaction partners of plant telomerase in vivo.Telomere healing following DNA polymerase arrest-induced breakages is likely the main mechanism generating chromosome 4p terminal deletions.Direct observation of nucleic acid binding dynamics by the telomerase essential N-terminal domain.
P2860
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P2860
The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalization
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
name
The N-terminus of hTERT contai ...... y and cellular immortalization
@ast
The N-terminus of hTERT contai ...... y and cellular immortalization
@en
type
label
The N-terminus of hTERT contai ...... y and cellular immortalization
@ast
The N-terminus of hTERT contai ...... y and cellular immortalization
@en
prefLabel
The N-terminus of hTERT contai ...... y and cellular immortalization
@ast
The N-terminus of hTERT contai ...... y and cellular immortalization
@en
P2093
P2860
P356
P1476
The N-terminus of hTERT contai ...... y and cellular immortalization
@en
P2093
David C F Sealey
Jennifer Cruickshank
Lea A Harrington
Michael A S Taboski
Mitsuhiko Ikura
P2860
P304
P356
10.1093/NAR/GKP1160
P407
P577
2009-12-23T00:00:00Z