Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer - Test2 - elhamkhani - TriplyDB

Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer

Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer

http://www.wikidata.org/entity/Q33767013

about

Potential of apoptotic pathway-targeted cancer therapeutic research: Where do we stand?Small-molecule SMAC mimetics as new cancer therapeutics Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?The Targeted SMAC Mimetic SW IV-134 is a strong enhancer of standard chemotherapy in pancreatic cancer A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics.Conjugation to a SMAC mimetic potentiates sigma-2 ligand induced tumor cell death in ovarian cancer Comparative benefits of Nab-paclitaxel over gemcitabine or polysorbate-based docetaxel in experimental pancreatic cancer Targeted pancreatic cancer therapy with the small molecule drug conjugate SW IV-134.BV6, an IAP antagonist, activates apoptosis and enhances radiosensitization of non-small cell lung carcinoma in vitro Therapeutic options for the management of pancreatic cancer.SMAC mimetic (JP1201) sensitizes non-small cell lung cancers to multiple chemotherapy agents in an IAP-dependent but TNF-α-independent manner Apricoxib, a novel inhibitor of COX-2, markedly improves standard therapy response in molecularly defined models of pancreatic cancer.Smac mimetic SM-164 potentiates APO2L/TRAIL- and doxorubicin-mediated anticancer activity in human hepatocellular carcinoma cells Genomic analysis of pterostilbene predicts its antiproliferative effects against pancreatic cancer in vitro and in vivo Smac mimetic-derived augmentation of chemotherapeutic response in experimental pancreatic cancer.Progesterone receptor-B induction of BIRC3 protects endometrial cancer cells from AP1-59-mediated apoptosis.A novel antagonist to the inhibitors of apoptosis (IAPs) potentiates cell death in EGFR-overexpressing non-small-cell lung cancer cells Fas death receptor signalling: roles of Bid and XIAP.Pancreatic ductal adenocarcinoma: a review of immunologic aspects.Cell death signaling and anticancer therapy Mechanism-based mathematical modeling of combined gemcitabine and birinapant in pancreatic cancer cells.Fibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer.Curcumin Induces Pancreatic Adenocarcinoma Cell Death Via Reduction of the Inhibitors of Apoptosis Stromal platelet-derived growth factor receptor α (PDGFRα) provides a therapeutic target independent of tumor cell PDGFRα expression in lung cancer xenografts.A novel small-molecule IAP antagonist, AZD5582, draws Mcl-1 down-regulation for induction of apoptosis through targeting of cIAP1 and XIAP in human pancreatic cancer.A preclinical evaluation of Minnelide as a therapeutic agent against pancreatic cancer.BIBF 1120 (nintedanib), a triple angiokinase inhibitor, induces hypoxia but not EMT and blocks progression of preclinical models of lung and pancreatic cancer.Targeting the XIAP/caspase-7 complex selectively kills caspase-3-deficient malignancies.Smac mimetics induce inflammation and necrotic tumour cell death by modulating macrophage activity.A Smac mimetic augments the response of urothelial cancer cells to gemcitabine and cisplatin.Anti-cancer IAP antagonists promote bone metastasis: a cautionary tale.Combining conditionally replicating adenovirus-mediated gene therapy with chemotherapy: a novel antitumor approach.Inhibitor of apoptosis proteins: fascinating biology leads to attractive tumor therapeutic targets.Proteomic tools for the characterization of cell death mechanisms in drug discovery.Combinatorial Screening of Pancreatic Adenocarcinoma Reveals Sensitivity to Drug Combinations Including Bromodomain Inhibitor Plus Neddylation Inhibitor.Detection of phosphatidylserine-positive exosomes for the diagnosis of early-stage malignancies.Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung cancer cells in vitro.Neutralizing murine TGFβR2 promotes a differentiated tumor cell phenotype and inhibits pancreatic cancer metastasis.Collagen signaling enhances tumor progression after anti-VEGF therapy in a murine model of pancreatic ductal adenocarcinoma.Second mitochondria-derived activator of caspase (SMAC) mimetic potentiates tumor susceptibility toward natural killer cell-mediated killing.

P2860

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P2860

Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer

http://www.wikidata.org/entity/Q33767013

description

2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

@zh-hk

2010年論文

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2010年論文

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2010年论文

@wuu

name

Smac mimetic increases chemoth ...... in mice with pancreatic cancer

@ast

Smac mimetic increases chemoth ...... in mice with pancreatic cancer

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type

label

Smac mimetic increases chemoth ...... in mice with pancreatic cancer

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Smac mimetic increases chemoth ...... in mice with pancreatic cancer

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prefLabel

Smac mimetic increases chemoth ...... in mice with pancreatic cancer

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Smac mimetic increases chemoth ...... in mice with pancreatic cancer

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0008-5472.CAN-09-3892

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Cancer Research

P1476

Smac mimetic increases chemoth ...... in mice with pancreatic cancer

@en

P2093

Christina L Roland

http://www.w3.org/2001/XMLSchema#string

Haizhou Sun

http://www.w3.org/2001/XMLSchema#string

Jason E Toombs

http://www.w3.org/2001/XMLSchema#string

John D Minna

http://www.w3.org/2001/XMLSchema#string

Juliet G Carbon

http://www.w3.org/2001/XMLSchema#string

Nabeel Bardeesy

http://www.w3.org/2001/XMLSchema#string

Noelle Williams

http://www.w3.org/2001/XMLSchema#string

Puja Gupta

http://www.w3.org/2001/XMLSchema#string

Rachel Greer

http://www.w3.org/2001/XMLSchema#string

Rolf A Brekken

http://www.w3.org/2001/XMLSchema#string

P2860

The Hallmarks of Cancer

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

TNF-alpha induces two distinct caspase-8 activation pathways

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

Apoptosis: targets in pancreatic cancer

Cancer statistics, 2007

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

IAP proteins: blocking the road to death's door

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2852-2861

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scholarly article

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10.1158/0008-5472.CAN-09-3892

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7

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70

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Nabeel Bardeesy

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2010-03-23T00:00:00Z

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42440639

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20332237

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2848888

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