Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice. - Test2 - elhamkhani - TriplyDB

Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice.

Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice.

http://www.wikidata.org/entity/Q33797938

about

Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease Parkinson's Disease: The Mitochondria-Iron Link The Dual Function of Reactive Oxygen/Nitrogen Species in Bioenergetics and Cell Death: The Role of ATP Synthase Neuroinflammation in Parkinson's disease and its potential as therapeutic target Mitochondria: A Therapeutic Target for Parkinson's Disease?Electron Transport Disturbances and Neurodegeneration: From Albert Szent-Györgyi's Concept (Szeged) till Novel Approaches to Boost Mitochondrial Bioenergetics Multiple system atrophy: a clinical and neuropathological perspective Mouse models of Parkinson's disease associated with mitochondrial dysfunction The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive?Parkinson's disease: animal models and dopaminergic cell vulnerability Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression The Parkinson's gene PINK1 regulates cell cycle progression and promotes cancer-associated phenotypes Towards translational therapies for multiple system atrophy Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's disease.NLRP3 inflammasome activation by mitochondrial ROS in bronchial epithelial cells is required for allergic inflammation Unaltered striatal dopamine release levels in young Parkin knockout, Pink1 knockout, DJ-1 knockout and LRRK2 R1441G transgenic mice.Loss of PINK1 impairs stress-induced autophagy and cell survival PINK1 enhances insulin-like growth factor-1-dependent Akt signaling and protection against apoptosis.Aspects of innate immunity and Parkinson's disease.Neuroinflammation in Parkinson's Disease and Related Disorders: A Lesson from Genetically Manipulated Mouse Models of α-Synucleinopathies.Mitochondrial Ca(2+) and neurodegeneration The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology.The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease PINK1 Deficiency Enhances Inflammatory Cytokine Release from Acutely Prepared Brain Slices.Parkinson's disease and enhanced inflammatory response.Mitochondria, calcium, and endoplasmic reticulum stress in Parkinson's disease.Oxidative stress in genetic mouse models of Parkinson's disease.The role of inflammation in sporadic and familial Parkinson's disease.Mitochondria: sensors and mediators of innate immune receptor signaling.The role of inflammatory and oxidative stress mechanisms in the pathogenesis of Parkinson's disease: focus on astrocytes.Unravelling mitochondrial pathways to Parkinson's disease.Ca2+ in quality control: an unresolved riddle critical to autophagy and mitophagy.Calcium signaling in Parkinson's disease.Compromised MAPK signaling in human diseases: an update.New insights on Parkinson's disease genes: the link between mitochondria impairment and neuroinflammation.PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons Parkin and PINK1 functions in oxidative stress and neurodegeneration.Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson's Disease.

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P2860

Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice.

http://www.wikidata.org/entity/Q33797938

description

2011 nî lūn-bûn

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2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2011 թվականի հունվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Increased mitochondrial calciu ...... fects in Pink1-deficient mice.

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Increased mitochondrial calciu ...... fects in Pink1-deficient mice.

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type

label

Increased mitochondrial calciu ...... fects in Pink1-deficient mice.

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Increased mitochondrial calciu ...... fects in Pink1-deficient mice.

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Increased mitochondrial calciu ...... fects in Pink1-deficient mice.

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Increased mitochondrial calciu ...... fects in Pink1-deficient mice.

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JOURNAL.PONE.0016038

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Increased mitochondrial calciu ...... fects in Pink1-deficient mice.

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Hansruedi Büeler

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Jignesh D Pandya

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Joshua Eason

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Lianteng Zhi

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Patrick G Sullivan

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Wayne A Cass

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Zhenyu Huang

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P2860

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

ATF3 enhances c-Jun-mediated neurite sprouting

Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: implications for Parkinson's disease

Deficiency of TNF receptors suppresses microglial activation and alters the susceptibility of brain regions to MPTP-induced neurotoxicity: role of TNF-alpha1

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)

Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10

PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling

Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission

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Ravi Shankar Akundi

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