SIRT6 promotes DNA repair under stress by activating PARP1 - Test2 - elhamkhani - TriplyDB

SIRT6 promotes DNA repair under stress by activating PARP1

SIRT6 promotes DNA repair under stress by activating PARP1

http://www.wikidata.org/entity/Q33803766

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Knock-in reporter mice demonstrate that DNA repair by non-homologous end joining declines with age The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells Effects of Oxidative Stress on Mesenchymal Stem Cell Biology Potential Modulation of Sirtuins by Oxidative Stress Intracellular Mono-ADP-Ribosylation in Signaling and Disease Protective effects and mechanisms of sirtuins in the nervous system Sirtuin 1 and sirtuin 3: physiological modulators of metabolism The controversial world of sirtuins SIRT1 as a therapeutic target in inflammaging of the pulmonary disease Targeting histone deacetylases for cancer therapy: from molecular mechanisms to clinical implications Pleiotropic cellular functions of PARP1 in longevity and aging: genome maintenance meets inflammation Metabolic modulation of chromatin: implications for DNA repair and genomic integrity Metabolism, longevity and epigenetics SIRTain regulators of premature senescence and accelerated aging Sirtuins in Cancer: a Balancing Act between Genome Stability and Metabolism DNA damage and repair in atherosclerosis: current insights and future perspectives Sirtuins, metabolism, and DNA repair Redox regulation of SIRT1 in inflammation and cellular senescence Sirtuins in epigenetic regulation Sirtuin-dependent epigenetic regulation in the maintenance of genome integrity Impacts on Sirtuin Function and Bioavailability of the Dietary Bioactive Compound Dihydrocoumarin The role of sirtuins in cardiac disease Sirtuins in metabolism, DNA repair and cancer Immune Cell Regulatory Pathways Unexplored as Host-Directed Therapeutic Targets for Mycobacterium tuberculosis: An Opportunity to Apply Precision Medicine Innovations to Infectious Diseases Circadian molecular clock in lung pathophysiology SIRT6 is required for maintenance of telomere position effect in human cells SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence Prevention of chemotherapy-induced ovarian damage: possible roles for hormonal and non-hormonal attenuating agents A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds Oxygen consumption and usage during physical exercise: the balance between oxidative stress and ROS-dependent adaptive signaling Nuclear DNA damage signalling to mitochondria in ageing Over expression of wild type or a catalytically dead mutant of Sirtuin 6 does not influence NFκB responses NAD(P)H:quinone oxidoreductase 1 (NQO1) localizes to the mitotic spindle in human cells Gemcitabine induces poly (ADP-ribose) polymerase-1 (PARP-1) degradation through autophagy in pancreatic cancer Sam68 Is Required for DNA Damage Responses via Regulating Poly(ADP-ribosyl)ation SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism RAD6 promotes homologous recombination repair by activating the autophagy-mediated degradation of heterochromatin protein HP1.

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P2860

SIRT6 promotes DNA repair under stress by activating PARP1

http://www.wikidata.org/entity/Q33803766

description

2011 nî lūn-bûn

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2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2011年の論文

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2011年論文

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2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

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name

SIRT6 promotes DNA repair under stress by activating PARP1

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SIRT6 promotes DNA repair under stress by activating PARP1

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type

label

SIRT6 promotes DNA repair under stress by activating PARP1

@ast

SIRT6 promotes DNA repair under stress by activating PARP1

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SIRT6 promotes DNA repair under stress by activating PARP1

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SIRT6 promotes DNA repair under stress by activating PARP1

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SCIENCE.1202723

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SIRT6 promotes DNA repair under stress by activating PARP1

@en

P2093

Amita Vaidya

http://www.w3.org/2001/XMLSchema#string

Andrei Seluanov

http://www.w3.org/2001/XMLSchema#string

Christopher Hine

http://www.w3.org/2001/XMLSchema#string

Matthew Au

http://www.w3.org/2001/XMLSchema#string

Michael Van Meter

http://www.w3.org/2001/XMLSchema#string

Vera Gorbunova

http://www.w3.org/2001/XMLSchema#string

Zhiyong Mao

http://www.w3.org/2001/XMLSchema#string

P2860

Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity

Human SIRT6 promotes DNA end resection through CtIP deacetylation

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1

SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging

Histone H4 lysine 16 acetylation regulates cellular lifespan

Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going?

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae.

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10.1126/SCIENCE.1202723

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6036

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332

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51226423

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21680843

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5472447

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