Contribution of inherited mutations in the BRCA2-interacting protein PALB2 to familial breast cancer. - Test2 - elhamkhani - TriplyDB

Contribution of inherited mutations in the BRCA2-interacting protein PALB2 to familial breast cancer.

Contribution of inherited mutations in the BRCA2-interacting protein PALB2 to familial breast cancer.

http://www.wikidata.org/entity/Q33810128

about

Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing Genomic/Epigenomic Alterations in Ovarian Carcinoma: Translational Insight into Clinical Practice PALB2: research reaching to clinical outcomes for women with breast cancer Inherited pancreatic cancer syndromes Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer Pioneering geneticist Mary-Claire King receives the 2014 Lasker~Koshland Special Achievement Award in Medical Science Novel germline PALB2 truncating mutations in African American breast cancer patients Inherited Mutations in Women With Ovarian Carcinoma Rare germline mutations in PALB2 and breast cancer risk: a population-based study.Assessment of PALB2 as a candidate melanoma susceptibility gene Pancreatic ductal adenocarcinoma: risk factors, screening, and early detection.Male fertility defect associated with disrupted BRCA1-PALB2 interaction in mice Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains.Breast-cancer risk in families with mutations in PALB2 Mutation analysis of PALB2 in BRCA1 and BRCA2-negative breast and/or ovarian cancer families from Eastern Ontario, Canada.Gene discovery in familial cancer syndromes by exome sequencing: prospects for the elucidation of familial colorectal cancer type X.Mutation analysis of BRCA1, BRCA2, PALB2 and BRD7 in a hospital-based series of German patients with triple-negative breast cancer.Hereditary ovarian cancer: not only BRCA 1 and 2 genes.A unified analytic framework for prioritization of non-coding variants of uncertain significance in heritable breast and ovarian cancer.Contribution of the PALB2 c.2323C>T [p.Q775X] founder mutation in well-defined breast and/or ovarian cancer families and unselected ovarian cancer cases of French Canadian descent.Requirement of heterogeneous nuclear ribonucleoprotein C for BRCA gene expression and homologous recombination.Analysis of PALB2 gene in BRCA1/BRCA2 negative Spanish hereditary breast/ovarian cancer families with pancreatic cancer cases Synthetic lethality of PARP inhibition in cancers lacking BRCA1 and BRCA2 mutations.Association of PALB2 sequence variants with the risk of familial and early-onset breast cancer in a South-American population Pathogenic PALB2 mutation in metastatic pancreatic adenocarcinoma and neuroendocrine tumour: A case report.PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function Routine testing for PALB2 mutations in familial pancreatic cancer families and breast cancer families with pancreatic cancer is not indicated Prevalence of PALB2 mutations in Australian familial breast cancer cases and controls Response to DNA damage of CHEK2 missense mutations in familial breast cancer.Clinical Application of Multigene Panels: Challenges of Next-Generation Counseling and Cancer Risk Management.PALB2 mutations in breast cancer patients from a multi-ethnic region in northwest China.Ovarian cancer: can proteomics give new insights for therapy and diagnosis?Genome-wide sequencing to identify the cause of hereditary cancer syndromes: with examples from familial pancreatic cancer.Genetic evaluation and testing for hereditary forms of cancer in the era of next-generation sequencing.Prevalence of PALB2 mutations in Australasian multiple-case breast cancer families Inherited and acquired alterations in development of breast cancer.Tumour morphology predicts PALB2 germline mutation status.PALB2 and breast cancer: ready for clinical translation!Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer.

P2860

Q24338777-81948311-79EE-4C84-9126-6D95E834DD44 Q24632270-8D8CCD03-135D-4F8A-9399-2E7657578D81 Q26740622-8BC33AA8-942B-4239-BD90-91525B207520 Q26751309-6455FA81-1EF8-47C4-9EDE-9FD8AB577D8E Q26853530-A2F6F568-1BE2-4A3D-8129-357A253373BC Q28586302-BF37ABCD-4205-4991-AA77-47166FC9045E Q28654820-37E37FB2-3A67-439B-83B2-DE2E5545BDBF Q28741002-5C66BCA0-2EBC-4C16-9C8A-20DBEF640FEB Q30353433-53F41AD3-6737-43A2-B1A0-DBEFBB242742 Q30417260-98F173D4-F10A-4DC2-A862-3A07E6CEC9A2 Q31167050-59A5B343-06ED-4D56-A93B-D9AE926A2ABC Q34093790-1D5FC0CB-90A9-49A1-AFA5-A622432361C2 Q34107377-56414B55-FBB0-4D60-A734-A72AF10C4539 Q34109816-FB9C1241-E1B0-44F7-87D7-B9CD22416670 Q34148873-075494D5-C7F5-4687-9A47-38160B08EEBA Q34178875-416F9DF0-B803-4B79-B237-74BAF463710F Q34269998-F5178BCA-0DA9-46FE-B3ED-815DCA8E23D6 Q34460831-C76B2E50-42A7-480D-B3BF-E252B565B833 Q34480707-3E3307BF-7261-4B92-AF4B-BB82C717AF18 Q34521706-FD16E59B-43A2-4216-ACEF-C93F16B1A2D2 Q34542998-EA570190-2962-4296-AC16-A038EF814166 Q34667979-CD922967-8685-45D2-89CA-BA0C0DE4BBAE Q34917808-976A8EB9-5590-44B5-8D3F-202FAED3DE5E Q35051154-12BAB650-731B-44B8-AF4E-C1D0B38DF28C Q35068734-BEA5840D-BD20-432A-9427-462DCCFC5555 Q35803533-BF9BA433-4BC8-4939-A7D1-BABD8CF62BD4 Q35867950-7313951B-F1C0-4B9D-AA35-1CCD1AD71F11 Q35899329-82E37D72-7FCD-40B5-AEDE-F597BE39DDA7 Q35964605-102C82CA-1940-47D0-AC6D-A215E122AB7B Q35997577-AF33346C-F113-43F8-82F1-A51953BA3E10 Q36101775-F214478A-2769-44B3-9118-AA6DD3EC5CF0 Q36202233-F2D0E760-6B8C-404A-8D1A-E1D30D7A57CB Q36820579-A2BC8465-CE19-4DAE-9D6D-B2F57B95172A Q36840576-3FE0CB92-FD2F-4CEC-9813-C5405779E9BB Q36849670-72643009-C831-48B1-9B88-E0593D8CF12E Q36903452-80A6B67D-5C3A-4040-9629-93FD0F8E1037 Q36925229-1BA18E59-53F9-4357-B660-1F394494B362 Q37003285-470505F5-AE55-44F8-85CF-C34151090526 Q37074279-BF50B0B7-26F8-4B23-A5D3-9C25E9361BC7 Q37086261-A4A7CCBB-0F43-4BCE-A227-B89E74641BD7

P2860

Contribution of inherited mutations in the BRCA2-interacting protein PALB2 to familial breast cancer.

http://www.wikidata.org/entity/Q33810128

description

2011 nî lūn-bûn

@nan

2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Contribution of inherited muta ...... LB2 to familial breast cancer.

@ast

Contribution of inherited muta ...... LB2 to familial breast cancer.

@en

type

label

Contribution of inherited muta ...... LB2 to familial breast cancer.

@ast

Contribution of inherited muta ...... LB2 to familial breast cancer.

@en

prefLabel

Contribution of inherited muta ...... LB2 to familial breast cancer.

@ast

Contribution of inherited muta ...... LB2 to familial breast cancer.

@en

P1433

Q33810128-F5717239-E1D9-4397-A653-58F97F3934E4

P1476

Q33810128-20FCB744-5195-467B-B0CC-2F72D0B49709

P2093

Q33810128-1FBFEC5D-9C0A-470C-A5D7-332ADC31ADA2

Q33810128-6792A979-CB99-405C-A8E2-C5120747F126

Q33810128-9DFEBF06-A516-4D29-9644-6688B0249D56

Q33810128-D04AC4D4-33F2-4A6E-8D21-C4F68F1CBADB

P2860

Q33810128-04AA818A-9FDB-4B17-8E63-E3ECF63A5232

Q33810128-0D5FCA9C-FA1F-4BE2-9304-DE6F9F489001

Q33810128-107EE8D2-3B02-48E8-9E87-7ECB289A6465

Q33810128-1D9E572D-FC07-434C-B336-918AB8CCC612

Q33810128-3DE015A5-9CEB-4E44-A84C-DAC8965106D6

Q33810128-4356FDF1-69FB-47F2-A9F5-991D828F8BB6

Q33810128-475269C2-5D2A-417E-BD63-449495BD57EB

Q33810128-51D5AF52-6312-4360-9B78-BF7F9FC9D3EC

Q33810128-56C21719-7C0C-409E-B9B3-E40A329858A2

Q33810128-57FAADB6-8191-4352-815B-580C3B1E3BA3

P304

Q33810128-7DA25764-135E-46D9-9737-45110E83A406

P31

Q33810128-EC304390-F5EC-45F7-ACD8-8B24378D726B

P356

Q33810128-1B285638-ACF9-4EC5-BBBD-A183BEE6C354

P407

Q33810128-7939482E-D42F-4364-A021-0AF4955B6651

P433

Q33810128-49E45687-F73E-45C8-A3EB-7EBE53C94ED8

P478

Q33810128-521735D5-8193-42C0-A31A-DFB926B8FCD7

P50

Q33810128-2D2C7010-21F9-4131-BFE4-A8B50C63998D

Q33810128-3298EF55-7198-4238-A284-1BC9E65A071C

Q33810128-7787DB6F-9422-4C37-9FAB-9004878FFB1F

Q33810128-93417DF9-699B-4071-B361-1085C92FA6AA

P577

Q33810128-261A2FF7-C3D1-4CD8-9486-59B10C91ED8A

P698

Q33810128-C66B2DD0-6F72-4404-A0B0-15AD101811A0

P932

Q33810128-39700492-58AD-48CE-A3E3-D2BAA53DC850

P356

0008-5472.CAN-10-3958

P1433

Cancer Research

P1476

Contribution of inherited muta ...... LB2 to familial breast cancer.

@en

P2093

Jessica B Mandell

http://www.w3.org/2001/XMLSchema#string

Ming K Lee

http://www.w3.org/2001/XMLSchema#string

Silvia Casadei

http://www.w3.org/2001/XMLSchema#string

Sunday Stray

http://www.w3.org/2001/XMLSchema#string

P2860

Detection of inherited mutations for breast and ovarian cancer using genomic capture and massively parallel sequencing

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

Analysis of PALB2/FANCN-associated breast cancer families

Penetrance analysis of the PALB2 c.1592delT founder mutation.

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

Characterization of BRCA1 and BRCA2 deleterious mutations and variants of unknown clinical significance in unilateral and bilateral breast cancer: the WECARE study.

A novel germline PALB2 deletion in Polish breast and ovarian cancer patients

PALB2/FANCN: recombining cancer and Fanconi anemia.

P304

2222-2229

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1158/0008-5472.CAN-10-3958

http://www.w3.org/2001/XMLSchema#string

P407

P433

6

http://www.w3.org/2001/XMLSchema#string

P478

71

http://www.w3.org/2001/XMLSchema#string

P50

Mary-Claire King

Barbara Norquist

John A Stamatoyannopoulos

P577

2011-02-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

21285249

http://www.w3.org/2001/XMLSchema#string

P932

3059378

http://www.w3.org/2001/XMLSchema#string