PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene - Test2 - elhamkhani - TriplyDB

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

http://www.wikidata.org/entity/Q24615080

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Genetic determinants and potential therapeutic targets for pancreatic adenocarcinoma Screening for BRCA1, BRCA2, CHEK2, PALB2, BRIP1, RAD50, and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast and/or ovarian cancer individuals Genome-wide association studies and the clinic: a focus on breast cancer UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination.ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2.Structural basis for recruitment of BRCA2 by PALB2 PALB2 is an integral component of the BRCA complex required for homologous recombination repair PALB2 regulates recombinational repair through chromatin association and oligomerization A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair 6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance Detection of inherited mutations for breast and ovarian cancer using genomic capture and massively parallel sequencing Mutations of the SLX4 gene in Fanconi anemia Genome-wide association study identifies novel breast cancer susceptibility loci Identification of common variants in the SHBG gene affecting sex hormone-binding globulin levels and breast cancer risk in postmenopausal women Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene Analysis of PALB2/FANCN-associated breast cancer families The biological effects and clinical implications of BRCA mutations: where do we go from here?Mechanisms of interstrand DNA crosslink repair and human disorders PALB2: research reaching to clinical outcomes for women with breast cancer Genetic causes of cancer predisposition in children and adolescents Inherited pancreatic cancer syndromes Fanconi anemia and the cell cycle: new perspectives on aneuploidy Mechanism and disease association of E2-conjugating enzymes: lessons from UBE2T and UBE2L3 Predictors and Modulators of Synthetic Lethality: An Update on PARP Inhibitors and Personalized Medicine The genetics of breast cancer risk in the post-genome era: thoughts on study design to move past BRCA and towards clinical relevance Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins Unraveling the mechanism of BRCA2 in homologous recombination PALB2: the hub of a network of tumor suppressors involved in DNA damage responses Germline mutations in RAD51D confer susceptibility to ovarian cancer Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis RAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombination Fanconi anaemia and the repair of Watson and Crick DNA crosslinks Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination Minding the gap: the underground functions of BRCA1 and BRCA2 at stalled replication forks Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer Loss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppression

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P2860

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

http://www.wikidata.org/entity/Q24615080

description

2007 nî lūn-bûn

@nan

2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի փետրվարին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

@ast

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

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PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

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type

label

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

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PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

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PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

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prefLabel

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

@ast

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

@en

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

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Nature Genetics

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PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

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Anna Elliott

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Anthony Renwick

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Deborah Thompson

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Hiran Jayatilake

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Katarina Spanova

http://www.w3.org/2001/XMLSchema#string

Patrick Kelly

http://www.w3.org/2001/XMLSchema#string

Rita Barfoot

http://www.w3.org/2001/XMLSchema#string

Sandra Hanks

http://www.w3.org/2001/XMLSchema#string

Sarah Reid

http://www.w3.org/2001/XMLSchema#string

Sheila Seal

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P2860

Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations

Biallelic inactivation of BRCA2 in Fanconi anemia

Cancer risks in BRCA2 mutation carriers.

Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.

ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles.

The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia.

Molecular pathogenesis of Fanconi anemia: recent progress.

Models of genetic susceptibility to breast cancer.

Biallelic BRCA2 mutations are associated with multiple malignancies in childhood including familial Wilms tumour.

The ATM-mediated DNA-damage response: taking shape.

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165-7

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scholarly article

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984904

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10.1038/NG1959

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2

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39

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Douglas F. Easton

Lesley McGuffog

Michael Stratton

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2007-02-01T00:00:00Z

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6599617

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1022261638

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17200668

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2871593

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