PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function - Test2 - elhamkhani - TriplyDB

PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function

PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function

http://www.wikidata.org/entity/Q35867950

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The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance Autophagy-mediated tumor promotion Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection PALB2: the hub of a network of tumor suppressors involved in DNA damage responses HER2 confers drug resistance of human breast cancer cells through activation of NRF2 by direct interaction Comparative analysis of NRF2-responsive gene expression in AcPC-1 pancreatic cancer cell line Regulation of Nrf2-an update The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism Oncogene PKCε controls INrf2-Nrf2 interaction in normal and cancer cells through phosphorylation of INrf2 The transcription factor NF-E2-related factor 2 (Nrf2): a protooncogene?Cancer-causing mutations in the tumor suppressor PALB2 reveal a novel cancer mechanism using a hidden nuclear export signal in the WD40 repeat motif Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance Male fertility defect associated with disrupted BRCA1-PALB2 interaction in mice The ubiquitin-conjugating enzyme UBE2E3 and its import receptor importin-11 regulate the localization and activity of the antioxidant transcription factor NRF2.Regulation of Nrf2 signaling and longevity in naturally long-lived rodents.Keap1 expression has independent prognostic value in pancreatic adenocarcinomas ATM-dependent Phosphorylation of the Fanconi Anemia Protein PALB2 Promotes the DNA Damage Response.Nrf2--a therapeutic target for the treatment of neurodegenerative diseases.Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination.Gankyrin has an antioxidative role through the feedback regulation of Nrf2 in hepatocellular carcinoma.Mitochondria and familial predisposition to breast cancer.Loss of Nrf2 abrogates the protective effect of Keap1 downregulation in a preclinical model of cutaneous squamous cell carcinoma.Role of Nrf2 and Autophagy in Acute Lung Injury PALB2 and breast cancer: ready for clinical translation!Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer.The emerging role of the Nrf2-Keap1 signaling pathway in cancer Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination Refining the role of BRCA1 in combating oxidative stress.Monitoring Keap1-Nrf2 interactions in single live cells.Molecular and chemical regulation of the Keap1-Nrf2 signaling pathway.Conservation of the Keap1-Nrf2 System: An Evolutionary Journey through Stressful Space and Time.A mechanism for the suppression of homologous recombination in G1 cells.p62/SQSTM1-Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer.KLHL39 suppresses colon cancer metastasis by blocking KLHL20-mediated PML and DAPK ubiquitination.The Role of PALB2 in the DNA Damage Response and Cancer Predisposition.Binding of disordered proteins to a protein hub.Comparison of Secondary Structure Formation Using 10 Different Force Fields in Microsecond Molecular Dynamics Simulations.Transcriptional Regulation by Nrf2.¹H, ¹⁵N and ¹³C backbone resonance assignments of the Kelch domain of mouse Keap1.CDK20 interacts with KEAP1 to activate NRF2 and promotes radiochemoresistance in lung cancer cells.

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PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function

http://www.wikidata.org/entity/Q35867950

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

@zh-tw

2012年论文

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2012年论文

@zh

2012年论文

@zh-cn

name

PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function

@ast

PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function

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type

label

PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function

@ast

PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function

@en

prefLabel

PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function

@ast

PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function

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Molecular and Cellular Biology

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PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function

@en

P2093

Ah-Ng Tony Kong

http://www.w3.org/2001/XMLSchema#string

Allen Alcivar

http://www.w3.org/2001/XMLSchema#string

Bijan Sobhian

http://www.w3.org/2001/XMLSchema#string

Bing Xia

http://www.w3.org/2001/XMLSchema#string

Donna D Zhang

http://www.w3.org/2001/XMLSchema#string

Hong Cai

http://www.w3.org/2001/XMLSchema#string

Jianglin Ma

http://www.w3.org/2001/XMLSchema#string

Ka Lung Cheung

http://www.w3.org/2001/XMLSchema#string

Monal Mehta

http://www.w3.org/2001/XMLSchema#string

Shridar Ganesan

http://www.w3.org/2001/XMLSchema#string

P2860

Free radicals and antioxidants in normal physiological functions and human disease

Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling

Structural basis for recruitment of BRCA2 by PALB2

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

Analysis of PALB2/FANCN-associated breast cancer families

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1506-1517

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scholarly article

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10.1128/MCB.06271-11

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8

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32

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2012-02-13T00:00:00Z

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221829712

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22331464

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3318596

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