Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains. - Test2 - elhamkhani - TriplyDB

Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains.

Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains.

http://www.wikidata.org/entity/Q34109816

about

Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2 Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins Molding BRCA2 function through its interacting partners PALB2: the hub of a network of tumor suppressors involved in DNA damage responses MEIOB targets single-strand DNA and is necessary for meiotic recombination Resistance to therapy in BRCA2 mutant cells due to loss of the nucleosome remodeling factor CHD4.Dual DNA-binding domains shape the interaction of Brh2 with DNA.Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry.Architectural plasticity of human BRCA2-RAD51 complexes in DNA break repair.Novel BRCA1 and BRCA2 pathogenic mutations in Slovene hereditary breast and ovarian cancer families Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients.A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization A second DNA binding site in human BRCA2 promotes homologous recombination Distinct binding of BRCA2 BRC repeats to RAD51 generates differential DNA damage sensitivity.RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination.BRCA2 diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cells Quantifying DNA double-strand breaks induced by site-specific endonucleases in living cells by ligation-mediated purification.Full in-frame exon 3 skipping of BRCA2 confers high risk of breast and/or ovarian cancer.Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer

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P2860

Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains.

http://www.wikidata.org/entity/Q34109816

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2011 nî lūn-bûn

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2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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Plasticity of BRCA2 function i ...... PALB2 and DNA binding domains.

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Plasticity of BRCA2 function i ...... PALB2 and DNA binding domains.

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Plasticity of BRCA2 function i ...... PALB2 and DNA binding domains.

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Plasticity of BRCA2 function i ...... PALB2 and DNA binding domains.

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Plasticity of BRCA2 function i ...... PALB2 and DNA binding domains.

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Plasticity of BRCA2 function i ...... PALB2 and DNA binding domains.

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Plasticity of BRCA2 function i ...... PALB2 and DNA binding domains.

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Plasticity of BRCA2 function i ...... PALB2 and DNA binding domains.

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Plasticity of BRCA2 function i ...... PALB2 and DNA binding domains.

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JOURNAL.PGEN.1002409

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Plasticity of BRCA2 function i ...... PALB2 and DNA binding domains

@en

P2093

Akinori Egashira

http://www.w3.org/2001/XMLSchema#string

Bing Xia

http://www.w3.org/2001/XMLSchema#string

Maria A Barbera

http://www.w3.org/2001/XMLSchema#string

Maria Jasin

http://www.w3.org/2001/XMLSchema#string

Nicolas Siaud

http://www.w3.org/2001/XMLSchema#string

Nicole Christ

http://www.w3.org/2001/XMLSchema#string

P2860

Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals

Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control

Purified human BRCA2 stimulates RAD51-mediated recombination

CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair

Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2.

Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats

Structural basis for recruitment of BRCA2 by PALB2

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

Insights into DNA recombination from the structure of a RAD51-BRCA2 complex

The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51

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e1002409

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scholarly article

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10.1371/JOURNAL.PGEN.1002409

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12

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7

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Katharina Schlacher

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2011-12-15T00:00:00Z

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51920813

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22194698

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3240595

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