Membrane association and protein conformation of alpha-synuclein in intact neurons. Effect of Parkinson's disease-linked mutations.
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Synaptic vesicle trafficking and Parkinson's diseaseAlpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recyclingThe N-terminus of α-synuclein is essential for both monomeric and oligomeric interactions with membranesα-Synuclein occurs physiologically as a helically folded tetramer that resists aggregationFocus on Extracellular Vesicles: Exosomes and Their Role in Protein Trafficking and Biomarker Potential in Alzheimer's and Parkinson's DiseaseDirect and/or Indirect Roles for SUMO in Modulating Alpha-Synuclein ToxicityAlpha-synuclein structure, functions, and interactionsThe role of α-synuclein and tau hyperphosphorylation-mediated autophagy and apoptosis in lead-induced learning and memory injuryAltered fatty acid composition of dopaminergic neurons expressing alpha-synuclein and human brains with alpha-synucleinopathiesMultiple β-sheet molecular dynamics of amyloid formation from two ABl-SH3 domain peptides.Switch region for pathogenic structural change in conformational disease and its predictionBiophysics of α-synuclein membrane interactions.Biophysical insights into how surfaces, including lipid membranes, modulate protein aggregation related to neurodegeneration.Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster.Biochemical characterization of the core structure of alpha-synuclein filaments.Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus.Modelling Ser129 phosphorylation inhibits membrane binding of pore-forming alpha-synuclein oligomersEffect of 4-hydroxy-2-nonenal modification on alpha-synuclein aggregation.Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra.Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutationsalpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins.The lipid-binding domain of wild type and mutant alpha-synuclein: compactness and interconversion between the broken and extended helix forms.Parkinson's disease and other alpha-synucleinopathies.Alpha-synuclein targets the plasma membrane via the secretory pathway and induces toxicity in yeast.Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation.Accumulation of α-synuclein in dementia with Lewy bodies is associated with decline in the α-synuclein-degrading enzymes kallikrein-6 and calpain-1.Anti-human α-synuclein N-terminal peptide antibody protects against dopaminergic cell death and ameliorates behavioral deficits in an AAV-α-synuclein rat model of Parkinson's disease.Influence of RNA interference on the mitochondrial subcellular localization of alpha-synuclein and on the formation of Lewy body-like inclusions in the cytoplasm of human embryonic kidney 293 cells induced by the overexpression of alpha-synuclein.Parkinson's disease, cortical dysfunction, and alpha-synuclein.Phosphorylation of α-synuclein protein at Ser-129 reduces neuronal dysfunction by lowering its membrane binding property in Caenorhabditis elegans.α-synuclein, LRRK2 and their interplay in Parkinson's disease.Molecular imaging of membrane interfaces reveals mode of beta-glucosidase activation by saposin C.α-Synuclein and nonhuman primate models of Parkinson's diseaseAlpha-Synuclein affects neurite morphology, autophagy, vesicle transport and axonal degeneration in CNS neurons.Helix periodicity, topology, and dynamics of membrane-associated alpha-synuclein.Immunotherapeutic Approaches Targeting Amyloid-β, α-Synuclein, and Tau for the Treatment of Neurodegenerative Disorders.Lentivirus mediated delivery of neurosin promotes clearance of wild-type α-synuclein and reduces the pathology in an α-synuclein model of LBD.Serine 129 phosphorylation of membrane-associated α-synuclein modulates dopamine transporter function in a G protein-coupled receptor kinase-dependent manner.Curvature dynamics of alpha-synuclein familial Parkinson disease mutants: molecular simulations of the micelle- and bilayer-bound forms.Review: Familial Parkinson's disease--genetics, clinical phenotype and neuropathology in relation to the common sporadic form of the disease.
P2860
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P2860
Membrane association and protein conformation of alpha-synuclein in intact neurons. Effect of Parkinson's disease-linked mutations.
description
2000 nî lūn-bûn
@nan
2000 թուականի Մարտին հրատարակուած գիտական յօդուած
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2000 թվականի մարտին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Membrane association and prote ...... on's disease-linked mutations.
@ast
Membrane association and prote ...... on's disease-linked mutations.
@en
type
label
Membrane association and prote ...... on's disease-linked mutations.
@ast
Membrane association and prote ...... on's disease-linked mutations.
@en
altLabel
Membrane Association and Protein Conformation of α-Synuclein in Intact Neurons
@en
prefLabel
Membrane association and prote ...... on's disease-linked mutations.
@ast
Membrane association and prote ...... on's disease-linked mutations.
@en
P2093
P2860
P356
P1476
Membrane association and prote ...... on's disease-linked mutations.
@en
P2093
P2860
P304
P356
10.1074/JBC.275.12.8812
P407
P577
2000-03-01T00:00:00Z