Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3'-kinase SH2 domains: a model for SH2-mediated receptor-target interactions
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Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulationThe SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T lymphocytesActivation of Src family kinases by colony stimulating factor-1, and their association with its receptorStructure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinasePhosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivoInteraction of the p85 subunit of PI 3-kinase and its N-terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changesMona, a novel hematopoietic-specific adaptor interacting with the macrophage colony-stimulating factor receptor, is implicated in monocyte/macrophage development.The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptorsShc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cellsCloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85The Croonian Lecture 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and diseaseT cell receptor zeta/CD3-p59fyn(T)-associated p120/130 binds to the SH2 domain of p59fyn(T)Gab3, a new DOS/Gab family member, facilitates macrophage differentiation.Phosphorylation of CSF-1R Y721 mediates its association with PI3K to regulate macrophage motility and enhancement of tumor cell invasion.Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblastsTyrosine 569 in the c-Fms juxtamembrane domain is essential for kinase activity and macrophage colony-stimulating factor-dependent internalizationSpecific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and VavRegulation of colony-stimulating factor 1 receptor signaling by the SH2 domain-containing tyrosine phosphatase SHPTP1Stimulation of human monocytes with macrophage colony-stimulating factor induces a Grb2-mediated association of the focal adhesion kinase pp125FAK and dynaminA region of the 85-kilodalton (kDa) subunit of phosphatidylinositol 3-kinase binds the 110-kDa catalytic subunit in vivo.The v-Src SH3 domain binds phosphatidylinositol 3'-kinase.Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells.Activation of c-Src in cells bearing v-Crk and its suppression by CskTyrosine 807 of the v-Fms oncogene product controls cell morphology and association with p120RasGAP.Macrophage colony-stimulating factor augments Tie2-expressing monocyte differentiation, angiogenic function, and recruitment in a mouse model of breast cancerPromotion of Tumor Invasion by Tumor-Associated Macrophages: The Role of CSF-1-Activated Phosphatidylinositol 3 Kinase and Src Family Kinase Motility Signaling.Sequential activation of phoshatidylinositol 3-kinase and phospholipase C-gamma2 by the M-CSF receptor is necessary for differentiation signalingBoth src-dependent and -independent mechanisms mediate phosphatidylinositol 3-kinase regulation of colony-stimulating factor 1-activated mitogen-activated protein kinases in myeloid progenitors.Scaffolding protein Gab2 mediates differentiation signaling downstream of Fms receptor tyrosine kinaseThe role of atypical protein kinase C in CSF-1-dependent Erk activation and proliferation in myeloid progenitors and macrophagesGenetic analysis of inherited leukodystrophies: genotype-phenotype correlations in the CSF1R gene.The effect of activating mutations on dimerization, tyrosine phosphorylation and internalization of the macrophage colony stimulating factor receptor.Phorbol 12-myristate 13-acetate-induced release of the colony-stimulating factor 1 receptor cytoplasmic domain into the cytosol involves two separate cleavage eventsColony stimulating factor-1 receptor signaling networks inhibit mouse macrophage inflammatory responses by induction of microRNA-21.Macrophage Migration and Its Regulation by CSF-1p85alpha subunit of class IA PI-3 kinase is crucial for macrophage growth and migration.Kinetics of p56lck and p60src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance.Functional specificity of cytoplasmic and transmembrane tyrosine kinases: identification of 130- and 75-kilodalton substrates of c-fps/fes tyrosine kinase in macrophages.Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectivelyMultiple cytokines stimulate the binding of a common 145-kilodalton protein to Shc at the Grb2 recognition site of Shc
P2860
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P2860
Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3'-kinase SH2 domains: a model for SH2-mediated receptor-target interactions
description
1992 nî lūn-bûn
@nan
1992 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Tyr721 regulates specific bind ...... d receptor-target interactions
@ast
Tyr721 regulates specific bind ...... d receptor-target interactions
@en
type
label
Tyr721 regulates specific bind ...... d receptor-target interactions
@ast
Tyr721 regulates specific bind ...... d receptor-target interactions
@en
prefLabel
Tyr721 regulates specific bind ...... d receptor-target interactions
@ast
Tyr721 regulates specific bind ...... d receptor-target interactions
@en
P2093
P2860
P1433
P1476
Tyr721 regulates specific bind ...... d receptor-target interactions
@en
P2093
M D Waterfield
P van der Geer
P2860
P304
P356
10.1002/J.1460-2075.1992.TB05181.X
P407
P577
1992-04-01T00:00:00Z